Investigation of applicability of alanine and radiochromic detectors to dosimetry of proton clinical beams

Nichiporov, D.; Kostjuchenko, V. I.; Puhl, James M.; Bensen, Debra L; Desrosiers, Marc F.; Dick, C. E.; McLaughlin, W.L.; Kojima, Takuji; Coursey, Bert M.; Zink, Sandra

doi:10.1016/0969-8043(95)00213-w

Cited by 36 publications

(18 citation statements)

References 10 publications

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“…However, the lack of standards guidance and concern over recombination in high fluence rate particle beams prompted additional absolute dosimetry comparisons. Therefore, two additional methods were used for this work: alanine dosimetry pellets 25,26 and thermoluminescent dosimetry. Nine alanine dosimetry pellets produced by Far West Technologies and having a NIST-traceable calibration were obtained from Armed Forces Radiobiological Research Institute ͑AFRRI͒ and irradiated in the reference field, at the center of SOBP, to a dose of 250 Gy.…”

Section: Iib2 Absolute Dosimetrymentioning

confidence: 99%

Clinical characterization of a proton beam continuous uniform scanning system with dose layer stacking

et al. 2008

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A proton beam delivery system on a gantry with continuous uniform scanning and dose layer stacking at the Midwest Proton Radiotherapy Institute has been commissioned and accepted for clinical use. This paper was motivated by a lack of guidance on the testing and characterization for clinical uniform scanning systems. As such, it describes how these tasks were performed with a uniform scanning beam delivery system. This paper reports the methods used and important dosimetric characteristics of radiation fields produced by the system. The commissioning data include the transverse and longitudinal dose distributions, penumbra, and absolute dose values. Using a 208 MeV cyclotron's proton beam, the system provides field sizes up to 20 and 30 cm in diameter for proton ranges in water up to 27 and 20 cm, respectively. The dose layer stacking method allows for the flexible construction of spread-out Bragg peaks with uniform modulation of up to 15 cm in water, at typical dose rates of 1 -3 Gy/ min. For measuring relative dose distributions, multielement ion chamber arrays, small-volume ion chambers, and radiographic films were employed. Measurements during the clinical commissioning of the system have shown that the lateral and longitudinal dose uniformity of 2.5% or better can be achieved for all clinically important field sizes and ranges. The measured transverse penumbra widths offer a slight improvement in comparison to those achieved with a double scattering beam spreading technique at the facility. Absolute dose measurements were done using calibrated ion chambers, thermoluminescent and alanine detectors. Dose intercomparisons conducted using various types of detectors traceable to a national standards laboratory indicate that the measured dosimetry data agree with each other within 5%.

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Section: Iib2 Absolute Dosimetrymentioning

confidence: 99%

Clinical characterization of a proton beam continuous uniform scanning system with dose layer stacking

et al. 2008

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“…Most of the systems in use are based on single or arrays of ionization chambers and on films, which are certainly precise but suffer for lengthy procedures. Nichiporov et al 4 examined the usefulness of multichannel detectors, while in many other studies [5][6][7][8][9] , film dosimetry has been proposed to verify dose distributions and perform QA in proton therapy. Film dosimetry, shown to be highly precise, does not give immediate results because the procedures required for preparing, scanning, calibration, and off-line analysis are time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Quality assurance of carbon ion and proton beams: A feasibility study for using the 2D MatriXX detector

et al. 2016

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Purpose: The quality assurance (QA) procedures in particle therapy centers with active beam scanning make extensive use of films, which do not provide immediate results. The purpose of this work is to verify whether the 2D MatriXX detector by IBA Dosimetry has enough sensitivity to replace films in some of the measurements. Methods: MatriXX is a commercial detector composed of 32×32 parallel plate ionization chambers designed for pre-treatment dose verification in conventional radiation therapy. The detector and GAFCHROMIC® films were exposed simultaneously to a 131.44 MeV proton and a 221.45 MeV/u carbon-ion therapeutic beam at the CNAO therapy center of Pavia -Italy, and the results were analyzed and compared. Results: The sensitivity MatriXX on the beam position, beam width and field flatness was investigated. For the first two quantities, a method for correcting systematic uncertainties, dependent on the beam size, was developed allowing to achieve a position resolution equal to 230 µm for carbon ions and less than 100 µm for protons. The beam size and the field flatness measured using MatriXX were compared with the same quantities measured with the irradiated film, showing a good agreement. Conclusions:The results indicate that a 2D detector such as MatriXX can be used to measure many parameters of a scanned ion beam quickly and precisely and suggest that the QA would benefit from a new protocol where the MatriXX detector is added to the existing systems.

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“…Other dosimetric systems such as radiochromic films, 72,73 alanine detectors, 73 and polymer gels 74 can be used for QA measurements. However, the use of these systems is limited because of saturation effects in the proton stopping region and because they are not real-time instruments.…”

Section: Ivc7 Qa Systems For Scanned Proton Beamsmentioning

confidence: 99%

Vision : Proton therapy

2009

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The first patients were treated with proton beams in 1955 at the Lawrence Berkeley Laboratory in California. In 1970, proton beams began to be used in research facilities to treat cancer patients using fractionated treatment regimens. It was not until 1990 that proton treatments were carried out in hospital-based facilities using technology and techniques that were comparable to those for modern photon therapy. Clinical data strongly support the conclusion that proton therapy is superior to conventional radiation therapy in a number of disease sites. Treatment planning studies have shown that proton dose distributions are superior to those for photons in a wide range of disease sites indicating that additional clinical gains can be achieved if these treatment plans can be reliably delivered to patients. Optimum proton dose distributions can be achieved with intensity modulated protons ͑IMPT͒, but very few patients have received this advanced form of treatment. It is anticipated widespread implementation of IMPT would provide additional improvements in clinical outcomes. Advances in the last decade have led to an increased interest in proton therapy. Currently, proton therapy is undergoing transitions that will move it into the mainstream of cancer treatment. For example, proton therapy is now reimbursed, there has been rapid development in proton therapy technology, and many new options are available for equipment, facility configuration, and financing. During the next decade, new developments will increase the efficiency and accuracy of proton therapy and enhance our ability to verify treatment planning calculations and perform quality assurance for proton therapy delivery. With the implementation of new multi-institution clinical studies and the routine availability of IMPT, it may be possible, within the next decade, to quantify the clinical gains obtained from optimized proton therapy. During this same period several new proton therapy facilities will be built and the cost of proton therapy is expected to decrease, making proton therapy routinely available to a larger population of cancer patients.

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Investigation of applicability of alanine and radiochromic detectors to dosimetry of proton clinical beams

Cited by 36 publications

References 10 publications

Clinical characterization of a proton beam continuous uniform scanning system with dose layer stacking

Clinical characterization of a proton beam continuous uniform scanning system with dose layer stacking

Quality assurance of carbon ion and proton beams: A feasibility study for using the 2D MatriXX detector

Vision : Proton therapy

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