Investigation of association between environmental and socioeconomic factors and preterm birth in California

Huang, Hongtai; Woodruff, Tracey J.; Baer, Rebecca J.; Bangia, Komal; August, Laura Meehan; Jellife-Palowski, Laura L.; Padula, Amy; Sirota, Marina

doi:10.1016/j.envint.2018.07.027

Cited by 48 publications

(50 citation statements)

References 52 publications

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“…(In our study, salicylamide levels were higher for the 5 women in the study, 4 cases and 1 control, who had chronic hypertension.) (R,S)- N -Acetyl-S-(2-hydroxy-3-buten-1-yl)- l -cysteine (MHB2) is a metabolite generated in vivo after exposure to 1,3-butadiene via smoking or air pollution 29 ; the link we found between MHB2 and sPTB is consistent with previous studies finding associations with these toxicants 30 , 31 .…”

Section: Discussionsupporting

confidence: 91%

Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case–control discovery phase study

Harville

et al. 2021

Sci Rep

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Understanding of causal biology and predictive biomarkers are lacking for hypertensive disorders of pregnancy (HDP) and preterm birth (PTB). First-trimester serum specimens from 51 cases of HDP, including 18 cases of pre-eclampsia (PE) and 33 cases of gestational hypertension (GH); 53 cases of PTB; and 109 controls were obtained from the Global Alliance to Prevent Prematurity and Stillbirth repository. Metabotyping was conducted using liquid chromatography high resolution mass spectroscopy and nuclear magnetic resonance spectroscopy. Multivariable logistic regression was used to identify signals that differed between groups after controlling for confounders. Signals important to predicting HDP and PTB were matched to an in-house physical standards library and public databases. Pathway analysis was conducted using GeneGo MetaCore. Over 400 signals for endogenous and exogenous metabolites that differentiated cases and controls were identified or annotated, and models that included these signals produced substantial improvements in predictive power beyond models that only included known risk factors. Perturbations of the aminoacyl-tRNA biosynthesis, l-threonine, and renal secretion of organic electrolytes pathways were associated with both HDP and PTB, while pathways related to cholesterol transport and metabolism were associated with HDP. This untargeted metabolomics analysis identified signals and common pathways associated with pregnancy complications.

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Section: Discussionsupporting

confidence: 91%

Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case–control discovery phase study

Harville

et al. 2021

Sci Rep

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“…Further, a growing body of research has assessed area-based measures of SES in conjunction with environmental exposures to investigate PTB from an environmental justice perspective. Such studies have found that exposures to air pollution and water pollution increase the risk for PTB, particularly among neighborhoods of low SES [70][71][72]. Future studies should consider the effects of these potential explanatory factors on gestational age at birth outcomes for women according to race/ethnicity and geography.…”

Section: Plos Onementioning

confidence: 99%

Racial and geographic variation in effects of maternal education and neighborhood-level measures of socioeconomic status on gestational age at birth: Findings from the ECHO cohorts

et al. 2021

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Preterm birth occurs at excessively high and disparate rates in the United States. In 2016, the National Institutes of Health (NIH) launched the Environmental influences on Child Health Outcomes (ECHO) program to investigate the influence of early life exposures on child health. Extant data from the ECHO cohorts provides the opportunity to examine racial and geographic variation in effects of individual- and neighborhood-level markers of socioeconomic status (SES) on gestational age at birth. The objective of this study was to examine the association between individual-level (maternal education) and neighborhood-level markers of SES and gestational age at birth, stratifying by maternal race/ethnicity, and whether any such associations are modified by US geographic region. Twenty-six ECHO cohorts representing 25,526 mother-infant pairs contributed to this disseminated meta-analysis that investigated the effect of maternal prenatal level of education (high school diploma, GED, or less; some college, associate’s degree, vocational or technical training [reference category]; bachelor’s degree, graduate school, or professional degree) and neighborhood-level markers of SES (census tract [CT] urbanicity, percentage of black population in CT, percentage of population below the federal poverty level in CT) on gestational age at birth (categorized as preterm, early term, full term [the reference category], late, and post term) according to maternal race/ethnicity and US region. Multinomial logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CIs). Cohort-specific results were meta-analyzed using a random effects model. For women overall, a bachelor’s degree or above, compared with some college, was associated with a significantly decreased odds of preterm birth (aOR 0.72; 95% CI: 0.61–0.86), whereas a high school education or less was associated with an increased odds of early term birth (aOR 1.10, 95% CI: 1.00–1.21). When stratifying by maternal race/ethnicity, there were no significant associations between maternal education and gestational age at birth among women of racial/ethnic groups other than non-Hispanic white. Among non-Hispanic white women, a bachelor’s degree or above was likewise associated with a significantly decreased odds of preterm birth (aOR 0.74 (95% CI: 0.58, 0.94) as well as a decreased odds of early term birth (aOR 0.84 (95% CI: 0.74, 0.95). The association between maternal education and gestational age at birth varied according to US region, with higher levels of maternal education associated with a significantly decreased odds of preterm birth in the Midwest and South but not in the Northeast and West. Non-Hispanic white women residing in rural compared to urban CTs had an increased odds of preterm birth; the ability to detect associations between neighborhood-level measures of SES and gestational age for other race/ethnic groups was limited due to small sample sizes within select strata. Interventions that promote higher educational attainment among women of reproductive age could contribute to a reduction in preterm birth, particularly in the US South and Midwest. Further individual-level analyses engaging a diverse set of cohorts are needed to disentangle the complex interrelationships among maternal education, neighborhood-level factors, exposures across the life course, and gestational age at birth outcomes by maternal race/ethnicity and US geography.

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“…In a study of the California's Office of Statewide Health Planning and Development birth cohort from 2009 to 2012 (1.8 million births), arsenic exposure through drinking water was weakly associated with PTB; for an increase of 1.38 parts per billion of arsenic, the adjusted odds ratio for PTB was 1.01 (95% confidence interval [CI], 1.00e1.013, P¼.01). 50 Almberg et al 51 Shi et al 52 studied rates of PTB among pregnant women in a region of New Hampshire that relies largely on unregulated private well water as a drinking source. The researchers subdivided arsenic exposure values into 3 categories (!1.0e4.9 mg/L, !5.0e9.9 mg/L, and !10 mg/L) and stratified their study population by age (<20 years old or !20 years old).…”

Section: Inorganic Arsenicmentioning

confidence: 99%

Exposure to toxic metals and per- and polyfluoroalkyl substances and the risk of preeclampsia and preterm birth in the United States: a review

Stone

Sutrave

Gascoigne

et al. 2021

American Journal of Obstetrics & Gynecology MFM

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Preeclampsia and preterm birth are among the most common pregnancy complications and are the leading causes of maternal and fetal morbidity and mortality in the United States. Adverse pregnancy outcomes are multifactorial in nature and increasing evidence suggests that the pathophysiology behind preterm birth and preeclampsia may be similar-specifically, both of these disorders may involve abnormalities in placental vasculature. A growing body of literature supports that exposure to environmental contaminants in the air, water, soil, and consumer and household products serves as a key factor influencing the development of adverse pregnancy outcomes. In pregnant women, toxic metals have been detected in urine, peripheral blood, nail clippings, and amniotic fluid. The placenta serves as a "gatekeeper" between maternal and fetal exposures, because it can reduce or enhance fetal exposure to various toxicants. Proposed mechanisms underlying toxicant-mediated damage include disrupted placental vasculogenesis, an up-regulated proinflammatory state, oxidative stressors contributing to prostaglandin production and consequent cervical ripening, uterine contractions, and ruptured membranes and epigenetic changes that contribute to disrupted regulation of endocrine and immune system signaling. The objective of this review is to provide an overview of studies examining the relationships between environmental contaminants in the US setting, specifically inorganic (eg, cadmium, arsenic, lead, and mercury) and organic (eg, per-and polyfluoroalkyl substances) toxicants, and the development of preeclampsia and preterm birth among women in the United States.

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Investigation of association between environmental and socioeconomic factors and preterm birth in California

Cited by 48 publications

References 52 publications

Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case–control discovery phase study

Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case–control discovery phase study

Racial and geographic variation in effects of maternal education and neighborhood-level measures of socioeconomic status on gestational age at birth: Findings from the ECHO cohorts

Exposure to toxic metals and per- and polyfluoroalkyl substances and the risk of preeclampsia and preterm birth in the United States: a review

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