Investigation of Basic Optical Properties of Tissue Phantoms Under 635 nm Low-Level Laser Irradiation

Durmus, Huseyin Okan; Kocaata, Sevgi; Naz, Gozde; Celik, Yunus Emre; Cetin, Emel; Karaböce, Baki; Seyidov, МirHasan Yu.

doi:10.1109/memea49120.2020.9137206

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…Light reflectance is considered in this experiment as the light from laser may be reflected away once it hits the ruby surface. While the light absorbance is the light that successfully pass the ruby [20,21].…”

Section: Methodsmentioning

confidence: 99%

Non-Invasive Grading Technique for Ruby Gemstone Using Charge-Coupled Device (Ccd)

Rahalim

Jamaludin²,

Raisin³

2023

AEJ

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Ruby is one of the most popular and high-value gemstones that always attract the gemologist and jeweler in the diamond market. The wide use of ruby in various industries makes the grading of this gems more complicated due to a lot of synthetic and imitation rubies are made. The current grading techniques are mostly depending on the human visual assessment which prone to errors. This paper proposes a system that helps in grading the clarity characteristic of the ruby in non-invasive manner. The system includes a charge-coupled devices (CCD) and laser that is designed in the most suitable and effective way to conduct inspection on the light intensity of the ruby which will then determine the clarity of the ruby. CCD linear sensor is widely known as the reliable sensor especially when use in the optical system. The CCD linear sensor capture the light intensity from the ruby and convert it into the voltage value. The result shows a value of 1.7918 V obtained from the CCD linear sensor when ruby is placed in the system. This concludes that the CCD system can detect even slightest changes in the light intensity that can pass through the ruby and falls on the CCD linear sensor. The system is proven to be a reliable and effective system with 80% accuracy.

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Section: Methodsmentioning

confidence: 99%

Non-Invasive Grading Technique for Ruby Gemstone Using Charge-Coupled Device (Ccd)

Rahalim

Jamaludin²,

Raisin³

2023

AEJ

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“…The macroscopic optical properties of the following soft tissue phantoms, such as absorbance, transmittance, reflectance, refractive index, and total attenuation coefficient, were calculated at 635 nm in our previous paper with a single integrating sphere test setup, as shown in Table 1 [15]. By using these macroscopic optical properties, microscopic optical properties, including the absorption coefficient, scattering coefficient, reduced scattering coefficient, total attenuation coefficient, and effective penetration depth, were calculated at 635 nm via the Kubelka-Munk function approach.…”

Section: Optical Properties Measurementsmentioning

confidence: 99%

“…In this study, the microscopic optical properties, which are the absorption coefficient, scattering coefficient, reduced scattering coefficient, and penetration depth, were determined at 635 nm for the first time using the Kubelka-Munk function approach over the macroscopic optical properties measured using a single integrating sphere system. The microscopic optical properties of the agar and Zerdine phantoms were calculated using basic macroscopic optical properties data from our previous study [15]. Therefore, it would be more advantageous to work with mathematical models that use current similar situations, rather than more complex methods.…”

Section: Introductionmentioning

confidence: 99%

Determination of microscopic optical properties of agar and Zerdine phantoms at 635 nm using Kubelka-Munk function approach: A numerical study

Durmus

Seyidov²

2022

IJAAS

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<p><span>Since the precise and accurate determination of the optical properties of materials is very important for the development and application of optical technology, the investigation of the optical properties of biological tissues with tissue-like phantoms is an important research field in the applications of lasers in medicine. In this study, after directly determining the macroscopic optical properties of the agar and Zerdine phantoms at 635 nm, including the absorbance, transmittance, reflectance, refractive index, and total attenuation coefficient with the single integrating sphere test apparatus; the microscopic optical characterization of these two different soft tissue phantoms were realized at 635 nm by using the Kubelka-Munk function approach. For this, the microscopic optical parameters, which are the absorption coefficient, scattering coefficient, reduced scattering coefficient, and penetration depth, were calculated over these determined macroscopic optical properties.</span></p>

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“…Advanced hydrogel TMMs such as polyacrylamide hydrogel, have been used in commercial US TMMs as Zerdine phantoms. 13 These have shown shelf lives of several years, and recently, polyacrylamidebased phantoms have been also developed and optimized for PAI. 14,15 Besides, a variety of other TMMs has been used to fabricate PAI phantoms, such as paraffin gel wax, 16,17 emulsions such as Intralipid, 18 glycerolin-polydimethylsiloxane (PDMS), 9 and polyvinyl chloride plastisol (PVCP) 19 Further developments in the field of TMMs for PAI, aimed to combine durability, long-term stability, as well as tunability of the acoustic and optical properties.…”

Section: Introductionmentioning

confidence: 99%

“…These water‐based phantoms can quickly degrade, thus limiting their mechanical durability and temporal stability to a few days. Advanced hydrogel TMMs such as polyacrylamide hydrogel, have been used in commercial US TMMs as Zerdine phantoms 13 . These have shown shelf lives of several years, and recently, polyacrylamide‐based phantoms have been also developed and optimized for PAI 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Development of a morphologically realistic mouse phantom for pre‐clinical photoacoustic imaging

et al. 2023

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BackgroundCharacterizations based on anatomically realistic phantoms are highly effective to perform accurate technical validation of imaging systems. Specifically for photoacoustic imaging (PAI), although a variety of phantom models with simplified geometries are reported, an unmet need still exists to establish morphologically realistic heterogeneous pre‐clinical phantoms. So the development of a mouse‐mimicking phantom can reduce the use of animals for the validation and standardization studies of pre‐clinical PAI systems and thus eventually translate the PAI technology to clinical research.PurposeHere we designed, developed, and fabricated a stable phantom that mimics the detailed morphology of a mouse, to be used as a realistic tool for PAI.MethodsThe mouse phantom, has been designed by using a combination of image modeling and 3D‐printing techniques. As a tissue‐mimicking material, we have used copolymer‐in‐oil‐based material that was recently proposed by the International Photoacoustic Standardization Consortium (IPASC). In particular, the anatomically realistic phantom has been modeled by using the real atlas of a mouse as a reference. The mouse phantom includes a 3D‐printed skeleton and the main abdominal organs such as the liver, spleen, and kidneys obtained by using doped copolymer‐in‐oil material with 3D‐printed molds. In addition, the acoustic and optical properties of the tissue‐mimicking material and the long‐term stability have been broadly characterized.ResultsFurthermore, our studies showed that the phantom is durable and stable for more than 200 days, under normal storage and repeated use. Fabrication protocol is easy to reproduce. As a result, the proposed morphologically realistic mouse phantom offers durability, material compatibility, and an unprecedented realistic resemblance to the actual rodents’ anatomy in PAI.ConclusionThis durable morphologically realistic mouse phantom would minimize the animal experiments in compliance with the 3R principle of Replacement, Reduction, and Refinement. To our knowledge, this is the first time an anatomically realistic heterogeneous mouse phantom has been proposed for PAI in pre‐clinical animal imaging and tested its durability over 200 days.

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Investigation of Basic Optical Properties of Tissue Phantoms Under 635 nm Low-Level Laser Irradiation

Cited by 4 publications

References 33 publications

Non-Invasive Grading Technique for Ruby Gemstone Using Charge-Coupled Device (Ccd)

Non-Invasive Grading Technique for Ruby Gemstone Using Charge-Coupled Device (Ccd)

Determination of microscopic optical properties of agar and Zerdine phantoms at 635 nm using Kubelka-Munk function approach: A numerical study

Development of a morphologically realistic mouse phantom for pre‐clinical photoacoustic imaging

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