Investigation of carotenoid conformations in myelin nerve upon changes in oxygen content

Максимов, Г. В.; Волков, В. В.; Parshina, E. Yu.; Akhalaia, Medea; Козлова, О. В.; Derinskaya, E. V.; Ревин, В. В.; Rubin, A. B.

doi:10.1134/s1607672907060099

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…It is known that oleic acid’s double bonds alter the conformation of the κ-carrageenan’s structure, causing tangling in its straight chain and preventing the structure from stacking closely together. Thus, a κ-carrageenan ester utilizing unsaturated fatty acids does not have a rigid and fixed structure, resulting in a reduction of the κ-carrageenan ester solution [ 31 , 32 ]. Then, the decrease in the viscosity of the κ-carrageenan ester can be caused by the breaking of hydrogen bonds and the weakening of the intermolecular forces of carrageenan after the introduction of the carbonyl group.…”

Section: Resultsmentioning

confidence: 99%

Gelling Power Alteration on Kappa-Carrageenan Dispersion through Esterification Method with Different Fatty Acid Saturation

Wardhana

Aanisah

Sopyan

et al. 2022

Gels

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The physicochemical properties of κ-carrageenan gels and their ester forms derived from different fatty-acid saturations were characterized and compared with those of native κ-carrageenan. Furthermore, stearic and oleic acids were used as the saturated and unsaturated fatty acids, respectively. Fourier-transform infrared (FTIR) spectra confirmed the introduction of the ester into the κ-carrageenan backbone. The thermogravimetric analysis showed that thermal stability increased along with the level of unsaturation, but there was a decrease in viscosity, hardness, and syneresis, which caused the consistency of the product to become more elastic. The results also showed that the ester form still has a swelling ability that is almost the same as that of κ-carrageenan. After being formulated into a gel dosage form, the product was successfully produced from the ester with unsaturated fatty acids, and it was more elastic than native κ-carrageenan and had good physical properties with spreadability that meets the requirements for topical preparations.

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Section: Resultsmentioning

confidence: 99%

Gelling Power Alteration on Kappa-Carrageenan Dispersion through Esterification Method with Different Fatty Acid Saturation

Wardhana

Aanisah

Sopyan

et al. 2022

Gels

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“…Our question is, when the process of aggregation begins, how does the carotenoid inhibit Aβ aggregation? We observed that a long chain of conjugated double bonds is present in these carotenoids (Figure 7), and that this polyene chain is responsible for their antioxidant activity by stabilization of radical species [52,107]. Nevertheless, how does the carotenoid inhibit Aβ aggregation?…”

Section: Neuroprotection By Carotenoids Through Modulation Of the mentioning

confidence: 99%

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis

Lakey-Beitia

Hegde

et al. 2019

IJMS

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Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder that affects the aging population worldwide. Endogenous and exogenous factors are involved in triggering this complex and multifactorial disease, whose hallmark is Amyloid-β (Aβ), formed by cleavage of amyloid precursor protein by β- and γ-secretase. While there is no definitive cure for AD to date, many neuroprotective natural products, such as polyphenol and carotenoid compounds, have shown promising preventive activity, as well as helping in slowing down disease progression. In this article, we focus on the chemistry as well as structure of carotenoid compounds and their neuroprotective activity against Aβ aggregation using molecular docking analysis. In addition to examining the most prevalent anti-amyloidogenic carotenoid lutein, we studied cryptocapsin, astaxanthin, fucoxanthin, and the apocarotenoid bixin. Our computational structure-based drug design analysis and molecular docking simulation revealed important interactions between carotenoids and Aβ via hydrogen bonding and van der Waals interactions, and shows that carotenoids are powerful anti-amyloidogenic molecules with a potential role in preventing AD, especially since most of them can cross the blood-brain barrier and are considered nutraceutical compounds. Our studies thus illuminate mechanistic insights on how carotenoids inhibit Aβ aggregation. The potential role of carotenoids as novel therapeutic molecules in treating AD and other neurodegenerative disorders are discussed.

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“…Bunow and Levin used the 2940/2885 cm −1 lipid band intensity ratio to measure lipid ordering degree in membranes [12]. Maksimov et al showed that the 1527/1160 cm −1 carotenoid intensity ratio reflects the local membrane viscosity of myelinated nerves [13,3].…”

Section: Distribution Of Raman Band Intensities In Different Regions ...mentioning

confidence: 99%

ATP-induced lipid membrane reordering in the myelinated nerve fiber identified using Raman spectroscopy

et al. 2013

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We demonstrate a successful application of Raman spectroscopy to the problem of lipid ordering with microscopic resolution in different regions of the myelinated nerve fiber. Simultaneous collection of Raman spectra of lipids and carotenoids has enabled us to characterize membrane fluidity and the degree of lipid ordering based on intensity ratios for the 1527/1160 and 2940/2885 cm −1 bands. We show that the intensity profiles of the major Raman bands vary significantly between the three major regions of myelinated nerve fiber: internode, paranode and the node of Ranvier. Mapping Raman peak intensities over these areas suggested that the carotenoid molecules are localized in the myelin membranes of nerve cells. Paranodal membranes were sensitive to extracellular ATP. ATP solutions (7 mM) influenced the 1527/1160 and 2940/2885 cm −1 intensity ratios. Changes in both carotenoid and lipid Raman spectra were in accord and indicated an increase in lipid ordering degree and decrease in membrane fluidity under ATP administration. The collected data provide evidence for the existence of a regulatory purinergic signaling pathway in the peripheral nervous system.

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Investigation of carotenoid conformations in myelin nerve upon changes in oxygen content

Cited by 5 publications

References 5 publications

Gelling Power Alteration on Kappa-Carrageenan Dispersion through Esterification Method with Different Fatty Acid Saturation

Gelling Power Alteration on Kappa-Carrageenan Dispersion through Esterification Method with Different Fatty Acid Saturation

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis

ATP-induced lipid membrane reordering in the myelinated nerve fiber identified using Raman spectroscopy

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