Investigation of Characteristics and Behavior of Loaded Carboplatin on the, Liposomes Nanoparticles, on the Lung and Ovarian Cancer: An In-Vitro Evaluation

roudsari, Majid Hasanzadegan; Saeidi, Nasim; Kabiri, Nahid; Ahmadi, Afrooz; Tabrizi, Maral Mazloumi; Shahmabadi, Hasan Ebrahimi; Khiyavi, Azim Akbarzadeh; Reghbati, Behnaz

doi:10.31557/apjcb.2016.1.1.9-13

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Pharmaceutics 2024, 16, 802. https://doi.org/10.3390/pharmaceutics16060802 https://www.mdpi.com/journal/pharmaceutics and organs. These malignancies can originate in various parts of the body, including the stomach, lungs, brain, and breasts [1][2][3][4][5][6][7][8][9]. Oral cavity cancer, a significant global health concern, manifests in areas such as the lips, hard palate, alveolar ridges, tongue, sublingual region, buccal mucosa, and posterior deltoid muscle of the molars [10][11][12][13][14][15].…”

Section: Cancer Encompasses a Variety Of Diseases Characterized By Th...mentioning

confidence: 99%

“…Cancer encompasses a variety of diseases characterized by the uncontrolled proliferation and division of abnormal cells that can invade and damage surrounding tissues and organs. These malignancies can originate in various parts of the body, including the stomach, lungs, brain, and breasts [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Oral cavity cancer, a significant global health concern, manifests in areas such as the lips, hard palate, alveolar ridges, tongue, sublingual region, buccal mucosa, and posterior deltoid muscle of the molars [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Saberian,

Jenča,

Petrášová

et al. 2024

Pharmaceutics

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This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities to facilitate targeted and localized drug administration, these systems enhance therapeutic outcomes significantly. Scaffolds, notably those coated with anti-cancer agents such as cisplatin and paclitaxel, have proven effective in inhibiting oral cancer cell proliferation, establishing a promising avenue for site-specific drug delivery. The application of synthetic scaffolds, including Poly Ethylene Glycol (PEG) and poly(lactic-co-glycolic acid) (PLGA), and natural materials, like collagen or silk, in 3D systems has been pivotal for controlled release of therapeutic agents, executing diverse anti-cancer strategies. A key advancement in this field is the advent of smart scaffolds designed for sequential cancer therapy, which strive to refine drug delivery systems, minimizing surgical interventions, accentuating the significance of 3D scaffolds in oral cancer management. These systems, encompassing local drug-coated scaffolds and other scaffold-based platforms, hold the potential to transform oral cancer treatment through precise interventions, yielding improved patient outcomes. Local drug delivery via scaffolds can mitigate systemic side effects typically associated with chemotherapy, such as nausea, alopecia, infections, and gastrointestinal issues. Post-drug release, scaffolds foster a conducive environment for non-cancerous cell growth, adhering and proliferation, demonstrating restorative potential. Strategies for controlled and targeted drug delivery in oral cancer therapy span injectable self-assembling peptide hydrogels, nanocarriers, and dual drug-loaded nanofibrous scaffolds. These systems ensure prolonged release, synergistic effects, and tunable targeting, enhancing drug delivery efficiency while reducing systemic exposure. Smart scaffolds, capable of sequential drug release, transitioning to cell-friendly surfaces, and enabling combinatorial therapy, hold the promise to revolutionize treatment by delivering precise interventions and optimized outcomes. In essence, scaffold-based drug delivery systems, through their varied forms and functionalities, are reshaping oral cancer therapy. They target drug delivery efficiency, diminish side effects, and present avenues for personalization. Challenges like fabrication intricacy, biocompatibility, and scalability call for additional research. Nonetheless, the perspective on scaffold-based systems in oral cancer treatment is optimistic, as ongoing advancements aim to surmount current limitations and fully leverage their potential in cancer therapy.

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Section: Cancer Encompasses a Variety Of Diseases Characterized By Th...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Saberian,

Jenča,

Petrášová

et al. 2024

Pharmaceutics

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Enhancing Cisplatin Delivery via Liposomal Nanoparticles for Oral Cancer Treatment

Ghanbarikondori,

Aliakbari,

Saberian

et al. 2024

Ind J Clin Biochem

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Optimization on thermal treatment synthesis of lactoferrin nanoparticles via Taguchi design method

et al. 2019

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Lactoferrin is a globular protein-based biopolymer which has many applications in pharmacy and food industry. In this study, human lactoferrin nanoparticles were synthesized by thermal treatment technique. Taguchi array design was employed to minimize the size of nanoparticles. To gain as this purpose, four main factors with four different levels involved as: lactoferrin concentration (1-4 mg/mL), pH values (6-9), heating rate of (2-5 °C/min) and final temperature of (60-90 °C) were investigated. In the following, prepared nanoparticles were characterized by dynamic light scattering, Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy analysis. Analysis of variance showed that lactoferrin concentration with the contribution percentage of 45% is most important in the preparation of nanoparticles. Also, optimal conditions for synthesized nanoparticles by thermal treatment technique were: LF concentration of 3 mg/mL, pH 8, heating rate of 3 °C/min and final temperature of 90 °C to achieve particle size of 188.8 nm, polydispersity index of 0.317 and zeta potential of − 52.2 mV.

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Investigation of Characteristics and Behavior of Loaded Carboplatin on the, Liposomes Nanoparticles, on the Lung and Ovarian Cancer: An In-Vitro Evaluation

Cited by 6 publications

References 14 publications

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Enhancing Cisplatin Delivery via Liposomal Nanoparticles for Oral Cancer Treatment

Optimization on thermal treatment synthesis of lactoferrin nanoparticles via Taguchi design method

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