Carboplatin is a chemotherapy drug which is used against some forms of cancer such as ovarian and lung carcinoma. This research was investigated to optimize and assess the Cytotoxicity of carboplatin Nanoliposomes on ovarian and lung cancer cell lines. Nanoparticles were prepared using reverse phase evaporation technique and characterized for light microscopy, spectrophotometry and drug-release properties. In the next step, A2780S and A2780CP (ovarian) and TC1 (lung) cell lines were used to determine the rate of Nano liposomal carboplatin cytotoxicity. In this research, size and zeta potentials are 244.3±16.7nm and 22.9± 1.7 mV, respectively. High encapsulation capacity (78.6±3.7%) confirmed the efficiency of the reverse phase evaporation technique. The cytotoxic effect of this Nano liposome on all cell lines was significantly increased when compared with the free drug (P<0.05). Our findings suggest that carboplatin liposomal Nanocarriers could serve as alternative chemotherapy modality for ovarian and lung cancer therapy.

Background and Aim: Toothbrushes cannot reach all interdental areas. Interdental cleaning is an important part of oral hygiene care. The purpose of this study was to compare the supragingival plaque removal efficacy of an interdental cleaning power device (Aquajet) and dental floss. Methods and Materials: Thirty subjects were enrolled in this single-blind, split mouth clinical trial. All the subjects received both written and verbal instructions and demonstrated proficiency prior to the study. The subjects were asked to abstain from oral hygiene methods for 48 hours prior to the study. The subjects were scored using the Proximal/Marginal Plaque Index (PMI). Then, the four oral quadrants were randomly assigned to one of two treatment groups: One upper and one lower quadrant: Aquajet and the other two quadrants: dental floss. The subjects were observed to ensure that they have covered all areas and have followed the instructions. Afterwards, they were scored again using the PMI. The pre and post-cleaning plaque scores were evaluated using two-way repeated measure ANOVA. Results: Both Aquajet and dental floss showed significant reduction of the baseline PMI in all dental areas (P<0.05), but the difference between the groups was not significant (P>0.05). Aquajet was significantly more effective than dental floss in reducing plaque on the mesial, mid-buccal and distal surfaces of upper first premolar and on the mesial and distal surfaces of upper second premolar and first molar (P<0.05). Conclusion:The results proved that oral irrigation with Aquajet is as effective as that with dental floss in plaque removal, and that Aquajet had significantly higher plaque removal efficacy at hard-to-reach dental surfaces.