Investigation of Contact-type Dermatitis Due to Compound Tincture of Benzoin**From the Medical Service, Section of Dermatology and Syphilology, Veterans Administration Hospital, Staten Island, New York.

Steiner, Karl; Leifer, William

doi:10.1038/jid.1949.109

Cited by 16 publications

(4 citation statements)

References 6 publications

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“…7 Numerous patients allergic to benzoin and CTB have been described. 7,[17][18][19][20][21][22][23] Mastisol patch testing is commonly positive in patients allergic to CTB, which may be explained by the presence of gum storax in both products (Table 1). 7,21 Several of these patients were also allergic to other ingredients of CTB.…”

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confidence: 99%

“…7,21 Several of these patients were also allergic to other ingredients of CTB. 7,[18][19][20] Concurrent patch test reactivity has been frequently observed among gum storax, balsam of Tolu (M. balsamum), balsam of Peru (Myroxylon pereirae), and S. benzoin. 7,[18][19][20]23,24…”

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confidence: 99%

“…Mastisol has been shown to provide better adhesion than CTB, 15,16 and 2 reports found a lower frequency of contact dermatitis from Mastisol compared with benzoin 6 or CTB 7 . Numerous patients allergic to benzoin and CTB have been described 7,17–23 …”

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confidence: 99%

“…Mastisol patch testing is commonly positive in patients allergic to CTB, which may be explained by the presence of gum storax in both products (Table 1). 7,21 Several of these patients were also allergic to other ingredients of CTB 7,18–20 . Concurrent patch test reactivity has been frequently observed among gum storax, balsam of Tolu ( M. balsamum ), balsam of Peru ( Myroxylon pereirae ), and S. benzoin 7,18–20,23,24 …”

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confidence: 99%

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Contact Dermatitis From Gum Mastic (Pistacia lentiscus) and Gum Storax (Liquidambar styraciflua) in Mastisol-Allergic Patients

Shaw

2020

Dermatitis

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Background: Mastisol Liquid Adhesive is widely used on the skin, especially after surgical procedures. It contains gum mastic, gum storax, methyl salicylate, and ethanol.Objective: The aims of the study were to review our experience patch testing patients allergic to Mastisol and to assess coreacting substances.Methods: We identified 18 patients who were allergic to Mastisol. Most of these had a history of postoperative or cardiac electrode dermatitis and underwent patch testing with multiple surgically related substances, including ingredients of Mastisol, compound tincture of benzoin, and fragrance-related ingredients and botanicals.Results and Conclusions: Among Mastisol-allergic patients, 13 (72%) of 18 were allergic to gum mastic, whereas 7 (44%) of 16 were allergic to gum storax. There was frequent coreactivity with various fragrance-related materials, including Majantol, Styrax benzoin, Myroxylon balsamum, Myroxylon pereirae, propolis, and others. Two gum mastic-allergic patients had positive patch tests with hydroperoxides of linalool and several other linalool-containing essential oils. As gum mastic contains linalool, it may explain some gum mastic reactions. Among patients without a history of postoperative contact dermatitis, 1 (0.4%) of 250 was patch test positive for gum mastic. This patient had allergic contact dermatitis from fragrances, so the gum mastic reaction was likely a true-positive relevant reaction.

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