Investigation of controlled solvent exchange precipitation of fluorescent organic nanocrystals

Kowalczyk, Piotr; Wojasiński, Michał; Wasiak, Iga; Ciach, Tomasz

doi:10.1016/j.colsurfa.2018.02.054

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Formulation Of Nanoparticles1

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2023

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“…For the NP formulation using the microfluidic device, the syringes containing organic and aqueous phases were placed in the syringe pumps and connected to the module. A concept of flow rate ratio (R) parameter was introduced, based on hydrodynamic-focusing research in the synthesis of polymeric nanoparticles [43].…”

Section: Formulation Of Nanoparticlesmentioning

confidence: 99%

Microfluidic-Assisted Formulation of ε-Polycaprolactone Nanoparticles and Evaluation of Their Properties and In Vitro Cell Uptake

Rybak,

Kowalczyk,

Czarnocka-Śniadała

et al. 2023

Polymers

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The nanoprecipitation method was used to formulate ε-polycaprolactone (PCL) into fluorescent nanoparticles. Two methods of mixing the phases were evaluated: introducing the organic phase into the aqueous phase dropwise and via a specially designed microfluidic device. As a result of the nanoprecipitation process, fluorescein-loaded nanoparticles (NPs) with a mean diameter of 127 ± 3 nm and polydispersity index (PDI) of 0.180 ± 0.009 were obtained. The profiles of dye release were determined in vitro using dialysis membrane tubing, and the results showed a controlled release of the dye from NPs. In addition, the cytotoxicity of the NPs was assessed using an MTT assay. The PCL NPs were shown to be safe and non-toxic to L929 and MG63 cells. The results of the present study have revealed that PCL NPs represent a promising system for developing new drug delivery systems.

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Section: Formulation Of Nanoparticlesmentioning

confidence: 99%