Investigation of Cox-2 inhibition of Laportea decumana (Roxb). Wedd extract to support its analgesic potential

Basy, Lukman La; Hertiani, Triana; Murwanti, Retno; Damayanti, Ema

doi:10.1016/j.jep.2023.116857

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Preprint1

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The influence of climate and human factors on a regional heat island in the Zhengzhou metropolitan area, China

Qiao,

Li,

Wang

et al. 2024

Environmental Research

View full text Add to dashboard Cite

The influence of climate and human factors on a regional heat island in the Zhengzhou metropolitan area, China

Qiao,

Li,

Wang

et al. 2024

Environmental Research

View full text Add to dashboard Cite

The Influence of Climate and Human Factors on a Regional Heat Island in the Zhengzhou Metropolitan Area, China

Qiao,

Li,

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Optimization of ultrasound-assisted extraction method of Syzygium cumini leaves based on extraction yield, content of bioactive compound, and inhibition of dipeptidyl peptidase IV enzyme activity using response surface methodology

Pujiastuti,

Nugroho,

Nisa

et al. 2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

View full text Add to dashboard Cite

Syzygium cumini leaves show potential to be developed as herbal medicine products against diabetes mellitus due to their high polyphenol contents. S. cumini was optimized using response surface methodology and Box–Behnken design with solvent solid ratio, solvent concentration, time and temperature, extraction yield, total flavonoid content (TFC), total phenolic content (TPC), and dipeptidyl peptidase IV (DPP-IV) enzyme inhibitory activity to obtain an effective and optimal extraction method. The conditions were achieved using a 70% ethanol solvent for the extraction, with a solvent–solid ratio of 21 v/w and run at 20°C for 30 min. The results showed an extraction yield of 83.875%, with TFCs measuring at 3.068 mg QE/g, TPCs of 65.029 mg GAE/g, and DPP-IV enzyme inhibition activity of 66.079%. Further analysis of the phytochemical profile using untargeted liquid chromatography-high-resolution mass spectrometry showed the presence of amine, amide, and fatty acid derivatives as major constituents. In addition, major flavonoids observed were myricetin and myricitrin, accounting for 0.2%. Ursolic acid and 25-azacholesterol accounted for 1.03% of the phenolics detected.

show abstract

Investigation of Cox-2 inhibition of Laportea decumana (Roxb). Wedd extract to support its analgesic potential

Cited by 3 publications

References 31 publications

The influence of climate and human factors on a regional heat island in the Zhengzhou metropolitan area, China

The influence of climate and human factors on a regional heat island in the Zhengzhou metropolitan area, China

The Influence of Climate and Human Factors on a Regional Heat Island in the Zhengzhou Metropolitan Area, China

Optimization of ultrasound-assisted extraction method of Syzygium cumini leaves based on extraction yield, content of bioactive compound, and inhibition of dipeptidyl peptidase IV enzyme activity using response surface methodology

Contact Info

Product

Resources

About