Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran

Almasi, Shohreh; Aliparasti, Mohammad Reza; Aliasgarzadeh, Akbar; Abd-Nikfarjam, Bahareh; Hyöty, Heikki; Knip, Mikael; Feizi, Hadi; Sioofy‐Khojine, Amir‐Babak; Rahnama, Badrossadat

doi:10.1016/j.imlet.2015.05.021

Cited by 9 publications

(7 citation statements)

References 47 publications

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“…The Protein Tyrosine Phosphatase Non‐receptor type 22 (PTPN22) T1D risk allele was associated with HbA1c level, but this finding was not replicated in an independent study that used the insulin dose‐adjusted HbA1c measure (IDAAC), defined by Mortensen et al in 2009 . Associations reported for the candidate genes interleukin‐6 (IL‐6), T lymphocyte‐associated antigen‐4 (CTLA4), and tumour necrosis factor‐Alpha (TNF‐α) genes did not remain significant after correcting for multiple testing. Another study reported suggestive TLR3 association with HbA1c level, but these results are inconclusive considering that a difference of age at onset of 7 years was noted between the two studied groups and so was possibly responsible for the effect …”

Section: Resultsmentioning

confidence: 99%

“…These candidate gene association studies have never been or have been poorly replicated, except for angiotensin I converting enzyme (ACE) gene . Five of the 13 selected studies reported significant or suggestive associations, which were however never replicated …”

Section: Resultsmentioning

confidence: 99%

“…[129][130][131] Five of the 13 selected studies reported significant or suggestive associations, which were however never replicated. 120,123,124,126,128 The most robust association was reported with the Erb-B2 Receptor Tyrosine Kinase 3 (ERBB3) rs2292239 T1D risk SNP and HbA1c level. The association remains significant after adjusting for insulin dose, gender, age at onset, and diabetes duration, 128…”

Section: Candidate Gene Studiesmentioning

confidence: 99%

“…Genes are grouped according to their reported disease association or known function. *: Unknown linked with diabetes candidate genes interleukin-6 (IL-6), 127 T lymphocyte-associated antigen-4 (CTLA4), 122,123 and tumour necrosis factor-Alpha (TNF-α) 126 genes did not remain significant after correcting for multiple testing.…”

Section: Figurementioning

confidence: 99%

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A systematic review of non‐genetic predictors and genetic factors of glycated haemoglobin in type 1 diabetes one year after diagnosis

Gloaguen

Bendelac

Nicolino

et al. 2018

Diabetes Metabolism Res

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Type 1 diabetes (T1D) results from autoimmune destruction of the pancreatic βcells. Although all T1D patients require daily administration of exogenous insulin, their insulin requirement to achieve good glycaemic control may vary significantly. Glycated haemoglobin (HbA1c) level represents a stable indicator of glycaemic control and is a reliable predictor of long-term complications of T1D. The purpose of this article is to systematically review the role of non-genetic predictors and genetic factors of HbA1c level in T1D patients after the first year of T1D, to exclude the honeymoon period. A total of 1974 articles published since January 2011 were identified and 78 were finally included in the analysis of non-genetic predictors. For genetic factors, a total of 277 articles were identified and 14 were included. The most significantly associated factors with HbA1c level are demographic (age, ethnicity, and socioeconomic status), personal (family characteristics, parental care, psychological traits...) and features related to T1D (duration of T1D, adherence to treatment …). Only a few studies have searched for genetic factors influencing HbA1c level, most of which focused on candidate genes using classical genetic statistical methods, with generally limited power and incomplete adjustment for confounding factors and multiple testing. Our review shows the complexity of explaining HbA1c level variations, which involves numerous correlated predictors. Overall, our review underlines the lack of studies investigating jointly genetic and non-genetic factors and their interactions to better understand factors influencing glycaemic control for T1D patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Candidate Gene Studiesmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

A systematic review of non‐genetic predictors and genetic factors of glycated haemoglobin in type 1 diabetes one year after diagnosis

Gloaguen

Bendelac

Nicolino

et al. 2018

Diabetes Metabolism Res

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show abstract

“…Several single nucleotide polymorphisms (SNP) have been identified in the CTLA-4 gene: −1661A/G and −1722C/T at the promoter, and the untranslated region of exon 1+49. Previous studies have shown the association of CTLA-4 with T1D (Almasi et al, 2015).…”

Section: Introductionmentioning

confidence: 90%

Association of Genetic Polymorphisms in a Sample of Iraqi Patients with Type1 Diabetes mellitus

Kandala¹,

Abdulridha²

2016

Int.J.Curr.Microbiol.App.Sci

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Molecular analysis of CTLA4 gene in patients with Behçet's disease from an Iranian Northwest Azeri population

et al. 2020

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Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran

Cited by 9 publications

References 47 publications

A systematic review of non‐genetic predictors and genetic factors of glycated haemoglobin in type 1 diabetes one year after diagnosis

A systematic review of non‐genetic predictors and genetic factors of glycated haemoglobin in type 1 diabetes one year after diagnosis

Association of Genetic Polymorphisms in a Sample of Iraqi Patients with Type1 Diabetes mellitus

Molecular analysis of CTLA4 gene in patients with Behçet's disease from an Iranian Northwest Azeri population

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