Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

Arslantaş, Ali; Ağırtaş, Mehmet Salih

doi:10.1002/slct.201702362

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…It has the advantages of high sensitivity and good selectivity . If the complexes intercalate with DNA, the complexes compete with EtBr to bind to DNA, thus releasing EtBrs, which reduces the fluorescence intensity of the EtBr‐DNA system . The form of action can be simplified into the following formula: M + EtBr·DNA = M·DNA + EtBr (M for complexes).…”

Section: Resultsmentioning

confidence: 99%

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

Zhu

Song

Liu³

et al. 2019

Applied Organom Chemis

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Two isomeric Zinc (II) complexes constructed by 3,5-bis(1-imidazoly) pyridine has been synthesized and characterized by single crystal X-ray diffraction, elemental analyses and infrared spectroscopy. The binding mode and ability of complex 1-2 with CT-DNA were studied by UV and fluorescence spectra. The intrinsic binding constant K b (K b1 = 2.305 × 10 4 M −1 , K b2 = 3.095 × 10 4 M −1 ) and the observed association constant K obs (K obs1 = 1.523*10 6 M −1 , K obs2 = 2.057*10 6 M −1 ) indicated that the insertion ability of complex 2 with CT-DNA is stronger than complex 1. Gel electrophoresis showed that complexes have a good ability to hydrolyze cleavage pBR322 plasmid DNA. The cytotoxicity and apoptosis studies showed that complexes exhibited excellent cytotoxic activity against HeLa cells, especially complex 2 had better growth inhibition than Cisplatin. Molecular docking study simulated the binding model of complexes with DNA (PDB:4av1), showing an imidazole plane of complex 2 can be inserted into a DNA base pair in relative parallel. Both complexes can be used as potential anticancer agents.

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Section: Resultsmentioning

confidence: 99%

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

Zhu

Song

Liu³

et al. 2019

Applied Organom Chemis

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show abstract

“…The gel electrophoresis experiments were recorded at 80 V during 3 h in the buffer solution (TBE) and the bands of the DNA were photographed using a BioRad system. In this method, the measurements were carried out with a Thermo Scientific gel electrophoresis system [29][30][31][32].…”

Section: Dna Binding Studiesmentioning

confidence: 99%

DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

et al. 2020

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Tetra phenoxy-3-methoxybenzoic acid substituted Co(II) and Cu(II) metal phthalocyanine compounds were reported for the first time. The structures of these compounds were elucidated by NMR, FT-IR, UV-vis spectroscopy, and elemental analysis. The UV/Vis, fluorescence spectra, viscosity and the thermal melting point techniques were implemented to analyze the DNA bonding activities of cobalt (II) and copper (II) complexes of phthalocyanine by calf thymus DNA. These techniques showed that the phthalocyanine complexes interacted with the DNA molecule through the intercalation mechanism. Additionally, among the methods above, the binding properties of DNA with the compounds 4 and 5 were studied by means of the agarose gel electrophoresis method. The complexes 4 and 5 bonded to the DNA molecule in the buffer system at a pH of 7.02. The findings of these methods proved that the Co(II) and Cu(II) complexes of phthalocyanine could be evaluated as potential cancer medicine for cancer treatment in the near future.

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“…Agarose gel electrophoresis experiments were conducted at 80 volts during 3 hours in the buffer solution, and the CT-DNA bands were then monitorized with a UV lamp. Agarose gel electrophoresis system from Thermo Scientific Owl company was used for this study [27][28][29][30][31].…”

Section: Agarose Gel Electrophoresis Experimentsmentioning

confidence: 99%

An Investigation upon DNA Interaction of 2 (3), 9 (10), 16 (17), 23 (24) –Tetrakis 4-(4-(2-phenylprop-2-yl) phenoxy) Phthalocyanine Compound

Arslantaş

Ağırtaş

Durmuş

2020

Hittite J. Sci. Eng.

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M ammal species with a weight of over one kilogram are known as large mammals [1]. In most ecosystems, species of large mammals living on land play prominent roles. Among these, large herbivores act as considerable modifiers of primary production, as well as nutrient cycles and soil properties, and even regimes of wildfires and bushfires [2]. Likewise, large carnivores play a major part in shaping the ecosystems they live in, by directly and indirectly effecting the species they prey on [3, 4]. Home range sizes of large mammal species are relatively bigger than those of other vertebrates, and thus they require large, uninterrupted ecosystems for feeding and breeding [5]. They are also known to be very sensitive to disturbance, and show considerable intolerance against it [6]. In Anatolia, many of the ecosystems that large mammals may find favourable have either become fragmented, or they are completely destroyed as a result of human activities-a serious threat to the continuity of large mammal populations. Identifying

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Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

Cited by 6 publications

References 52 publications

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

An Investigation upon DNA Interaction of 2 (3), 9 (10), 16 (17), 23 (24) –Tetrakis 4-(4-(2-phenylprop-2-yl) phenoxy) Phthalocyanine Compound

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