Investigation of Drug Release from Solids IV

Wurster, Dale Eric; Polli, Gerald P.

doi:10.1002/jps.2600500506

Journal of Pharmaceutical Sciences

1961

DOI: 10.1002/jps.2600500506

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Investigation of Drug Release from Solids IV

Dale Eric Wurster

Gerald P. Polli

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Cited by 18 publications

(2 citation statements)

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“…Surfactants generally improve wetting by reducing the interfacial energy for the liquid-vapor interface and adsorbing on the substrate to cause a reduction in the interfacial energy for the solid-liquid interface. However, some authors (12)(13)(14)(15) have demonstrated a solubilizing effect at concentrations below the critical micellar concentration (CMC). A better understanding of the wetting properties of biorelevant media is necessary to rationally formulate dissolution media that accurately account for the critical factors involved in the dissolution process (8).…”

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confidence: 99%

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release

Vidal¹,

Castro²,

Bruni³

et al. 2014

Dissolution Technol.

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The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble compounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to improve their apparent solubilities under physiologically relevant conditions with surfactants as wetting agents. Albendazole (ABZ), one of the most effective broad-spectrum antihelminthic agents, has a very low aqueous solubility, which leads to an erratic availability. Solid dispersions (SD) with different amounts of carriers (P188 and PEG6000) were formulated to improve the ABZ dissolution rate. When the dissolution test is used to infer biopharmaceutical properties of the dosage form, it is essential that the method simulates the gastrointestinal conditions. The objective of this study was to examine the applicability of different dissolution media to the evaluation of ABZ and ABZ-SD dissolution rates. Dissolution profiles were performed by the official method (0.1 N HCl) and Simulated Gastric Fluid modified with a surfactant. Wetting was evaluated through the determination of surface tension and contact angle of the solutions. The dissolution rate of ABZ was clearly affected by the variables assessed in this study. These results have implications in the design of physiologically based dissolution media.

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mentioning

confidence: 99%

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release

Vidal¹,

Castro²,

Bruni³

et al. 2014

Dissolution Technol.

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“…Gibaldi & Feldman (1967) have described an in vitro dissolution rate method using a sink condition, in which dissolved drug is partitioned into an organic phase. The use of an adsorbent material may also achieve the sink condition (Wurster & Polli, 1961), but may affect the viscosity and considerably retard the dissolution process (Wurster & Polli, 1964).…”

mentioning

confidence: 99%

Dissolution rates of sparingly soluble tablets

Hersey

Barzilay

1969

Journal of Pharmacy and Pharmacology

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The automated dialysis method offers an opportunity for the accurate evaluation of the dissolution rates of sparingly soluble dosage forms. By the analysis of kinetic models, the dissolution rates for disintegrating and non‐disintegrating dosage forms may be calculated. The theory is used to examine the effect of additives and compression force on the dissolution rates of sulphathiazole tablets. At the fairly low compression forces used (640–1430 kg) the dissolution rate gradually increases due to penetration of the tablet by the dissolution medium. Polyethylene oxide causes an initial rapid increase in dissolution rate, but the formation of a mucilaginous film results in a constant rate. Using starch, dissolution rate increases rapidly as a result of tablet disintegration. This disintegration is shown to make available less than half the surface area of the original powder. The dissolution rate constant for sulphathiazole under the experimental conditions is 2–75 × 10−4 cm min−1.

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Establishment of sink conditions in dissolution rate determinations. Theoretical considerations and application to nondisintegrating dosage forms

Gibaldi

Feldman

1967

Journal of Pharmaceutical Sciences

419

170

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Investigation of Drug Release from Solids IV

Cited by 18 publications

References 6 publications

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release

Dissolution rates of sparingly soluble tablets

Establishment of sink conditions in dissolution rate determinations. Theoretical considerations and application to nondisintegrating dosage forms

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