Investigation of dual-bend serpentine/spiral waveguides coupled to a microchannel system for competent, evanescent-wave-absorption-based, on-chip, biological-/chemical-sensing applications

Abstract

The reported device is a versatile sensing-platform, with high sensitivity, for any chemical/biological-sensing applications, if suitable surface adaptation is first performed to the microchannel-system-embedded duel-bend waveguide-probe.

Bend loss fiber optics design based on sinusoidal and ellipse configurations

“…The range of the angle of incidence at the first bend in an ellipse shape, as shown in Fig. 3, can be explained by previous equations that are modified by [13] for the spiral waveguide. Furthermore, the range of the angle of incidence with the normal to the core-cladding interface at the first bend changes and values of the angle of incidence at the second bend can be calculated as follows: ------------------------------------------------------ ------------------------------ ------------------------------------------------------ --------------------B w -------------------B' w h' -------------------------------= Fig.…”

“…With this situation, the ray is capable of propagating through the sensing part. If θ represents the angle that a guided ray makes with the normal to the core-cladding interface in the straight fiber, then the corresponding angle φ at the outer surface of the bent-core is given by the expression done by [11][12][13]: (4) where h is the distance at which the ray is incident on the entrance of fiber from the core-cladding boundary B is the bending radius, and w is the waveguide width. Similarly, angle δ of the ray at the inner surface of the bent-core is given by: (5) Fig.…”

“…( 6) and ( 7). This explanation was done by [13] but at S-shaped waveguide. Hence, --------------------------------------- ----------------------------------------= Fig.…”

Amalgamation of diverse hydrodynamic effects with novel triple-sided membrane valves for developing a microfluidic device for filterless and continuous water purification

“…organic/inorganic contaminants present in the water). Consequently, it would be mostly simple to incorporate an optical evanescent wave absorbance or LSPR-oriented microuidic biosensor [10][11][12]20,21 component in the proposed particle/bacterial cell separation microuidic element in a single microuidic biosensor design. Positively, the combination of this proposed particle/bacterial cell separation microuidic unit with a suitable microuidic biosensing unit would improve its analytical relevance and improve the extent of its potential applications.…”

3D-Printed Impedance Micropump for Continuous Perfusion of the Sample and Nutrient Medium Integrated with a Liver-On-Chip Prototype

“…The impedance micropump does not require any complex components such as blades, microvalves, piezo elements, or high electric fields, making it safe for studies involving perfusion and handling of sensitive biomolecules and cell-based studies. Accordingly, it is typically straightforward to integrate an optical evanescent wave absorbance or a localized surface plasmon resonance-oriented microfluidic biosensor module to the proposed micropump in a single microfluidic biosensor design. − Adjusting simple parameters such as the excitation frequency or tapping location can change the flow’s direction and provide a versatile flow output. Such characteristics make the impedance micropump well-suited to various applications ranging from point-of-care devices, drug toxicity testing, organ-on-a-chip, and drug delivery with precisely controlled flow rates.…”