Investigation of Dual Plasmonic Core-Shell Ag@Cus Nanoparticles for Potential Surface-Enhanced Raman Spectroscopy-Guided Photothermal Therapy

Abstract

Aim: To prepare efficient metal-semiconductor nanoparticles as noninvasive, real-time imaging probes for photothermal therapy (PTT) applications. Materials & methods: A bottom-up approach was used to fabricate core-shell Ag@CuS nanoparticles (NPs). PTT and Raman mapping were done using HeLa cells. Theoretical simulation of electric field enhancement and heat dissipation density of Ag@CuS NPs was performed. Results: PTT-induced hyperthermia was achieved under 940 nm near-infrared light irradiation. Surface-enhanced Raman spectroscopy (SERS) signals of dye molecules were observed when conjugated with Ag@CuS NPs. Conclusion: Ag@CuS NPs are found to be efficient for SERS imaging and localized heating under laser irradiation, making a promising candidate for SERS-guided PTT.

Smart Design of Noble Metal–Copper Chalcogenide Dual Plasmonic Heteronanoarchitectures for Emerging Applications: Progress and Prospects

“…However, despite remarkable successes, though few reports devoted to Ag-based dual plasmonic nanomaterials have been published. 56 Incorporation of an Ag core is highly desired because the higher enhancement of the electromagnetic field is achieved by the stronger interaction of the conduction electrons oscillations within Ag nanoparticles than in gold NPs. 57 Their disadvantage compared to Au NPs, in the scope of the formation of dual plasmonic heterostructures, is high reactivity.…”

“…54,86 Interestingly, when comparing the generation of OH radicals mediated by amorphous Au@ Cu 2−x Se hybrid particles with those containing Cu 2−x Se in a highly crystalline form, the first type showed higher photocatalytic efficiency. 56 To improve the antitumor efficacy, chemotherapy is used together with photothermal therapy (PTT), which converts external near-infrared light into heat to ablate tumors. The rational design of photothermal agents at the nanoscale has a high priority among material researchers to improve cancer treatment and bacteria cells damage by efficiently converting incident energy into heat.…”

“…Among copper chalcogenides, improved antioxidant activity, high biocompatibility, and low toxicity have been detected in copper selenide. , Au@Cu 2– x Se heterogeneous nanostructures have been demonstrated to assist Fenton-like reactions generating •OH from H 2 O 2 and photothermal conversion due to strong NIR extinction. Extra •OH can be effectively formed by the photocatalytic reaction induced by excited plasmonic holes from dual plasmonic Au@Cu 2– x Se nanosystems. , Interestingly, when comparing the generation of OH radicals mediated by amorphous Au@Cu 2– x Se hybrid particles with those containing Cu 2– x Se in a highly crystalline form, the first type showed higher photocatalytic efficiency …”

“…Dual plasmonic heteronanostructures based on an Au core are the most common and actively investigated. However, despite remarkable successes, though few reports devoted to Ag-based dual plasmonic nanomaterials have been published . Incorporation of an Ag core is highly desired because the higher enhancement of the electromagnetic field is achieved by the stronger interaction of the conduction electrons oscillations within Ag nanoparticles than in gold NPs .…”

Size Effect in Plasmon Resonance of Gold-Copper Sulfide Core-Shell Nanoparticles

“…As a result, they demonstrate a synergistic combination of the nanoscale semiconductors characteristic optoelectronic properties and the optical response of localized surface plasmon resonance. Importantly, such nanoparticles are characterized by enhanced plasmonic properties in the near-infrared wavelength range, making them suitable for wide applications [5]. The properties of both localized surface Інфокомунікаційні технології та електронна інженерія, Вип.…”