Investigation of enhanced hemocompatibility and tissue compatibility associated with multi-functional coating based on hyaluronic acid and Type IV collagen

Li, Jingan; Zhang, Kun; Ma, Wenyong; Wu, Feng; Yang, Ping; He, Zikun; Huang, Nan

doi:10.1093/rb/rbv030

Cited by 28 publications

(10 citation statements)

References 46 publications

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“…It is known that platelet morphology is related to its activation state [22]. To examine the activity of platelets adhered to the surfaces after various coatings, the adhesion and morphology of the adhered platelets were characterized by SEM.…”

Section: Resultsmentioning

confidence: 99%

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Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility

et al. 2019

Regenerative Biomaterials

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In this study, we designed a double layer-coated vascular stent of 316L stainless steel using an ultrasonic spray system to achieve both antiproliferation and antithrombosis. The coating included an inner layer of graphene oxide (GO) loaded with docetaxel (DTX) and an outer layer of carboxymethyl chitosan (CMC) loaded with heparin (Hep). The coated surface was uniform without aggregation and shedding phenomena before and after stent expanded. The coating treatment was able to inhibit the adhesion and activation of platelets and the proliferation and migration of smooth muscle cells, indicating the excellent biocompatibility and antiproliferation ability. The toxicity tests showed that the GO/DTX and CMC/Hep coating did not cause deformity and organ abnormalities in zebrafish under stereomicroscope. The stents with GO double-layer coating were safe and could effectively prevent thrombosis and in-stent restenosis after the implantation into rabbit carotid arteries for 4–12 weeks.

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Section: Resultsmentioning

confidence: 99%

“…The hemolytic rate of GCC was the lowest among the coatings of 316L SS, DAC and GDC. After the implantation, the stent interacts with blood cells, including platelets [22]. The poor blood compatibility of coating may lead to not only hemolysis but also the formation of thrombosis [39, 40].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility

et al. 2019

Regenerative Biomaterials

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“…While these results are encouraging, none of these coatings are inherently anti-thrombogenic. In fact, hemo-compatibility of collagen IV and fibronectin has been examined by other groups, and both were found to activate platelets in the absence of anti-platelet therapies such as hyaluronic acid or heparin [12,13]. …”

Section: Introductionmentioning

confidence: 99%

Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix

et al. 2017

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Each year, hundreds of thousands coronary bypass procedures are performed in the US, yet there currently exists no off-the-shelf alternative to autologous vessel transplant. In the present study, we investigated the use of mouse thrombospondin-2 knockout (TSP2 KO) cells, which secrete a non-thrombogenic and pro-migratory extracellular matrix (TSP2 KO ECM), to modify small diameter vascular grafts. To accomplish this, we first optimized the incorporation of TSP2 KO ECM on decellularized rat aortas. Because MMP levels are known to be elevated in TSP2 KO cell culture, it was necessary to probe the effect of the modification process on the graft's mechanical properties. However, no differences were found in suture retention, Young's modulus, or ultimate tensile strength between modified and unmodified grafts. Platelet studies were then performed to determine the time point at which the TSP2 KO ECM sufficiently reduced thrombogenicity. Finally, grafts modified by either TSP2 KO or WT cells or unmodified grafts, were implanted in an abdominal aortic interposition model in rats. After 4 weeks, grafts with incorporated TSP2 KO ECM showed improved endothelial and mural cell recruitment, and a decreased failure rate compared to control grafts. Therefore, our studies show that TSP2 KO ECM could enable the production of off-the-shelf vascular grafts while promoting reconstruction of native vessels.

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“…For pro-endothelial drugs or factors, there are many choices, such as fibronectin [ 20 ], laminin [ 21 ], collagen [ 22 ], peptides [ 23 ] and specific antibodies [ 24 ], but most of these drugs or proteins are hydrosoluble, which may lead to initial burst release after loading and implantation, but which is not a favorable durative pro-endothelial property. Estradiol is the most active estrogen that can be secreted by both men and women [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Cardiovascular Stent Material 316L SS with Estradiol-Loaded Poly (trimethylene carbonate) Film for Better Biocompatibility

Yao

et al. 2017

Polymers

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Abstract:A delay in the endothelialization process represents a bottleneck in the application of a drug-eluting stent (DES) during cardiovascular interventional therapy, which may lead to a high risk of late restenosis. In this study, we used a novel active drug, estradiol, which may contribute to surface endothelialization of a DES, and prepared an estradiol-loaded poly (trimethylene carbonate) film (PTMC-E5) on the surface of the DES material, 316L stainless steel (316L SS), in order to evaluate its function in improving surface endothelialization. All the in vitro and in vivo experiments indicated that the PTMC-E5 film significantly improved surface hemocompatibility and anti-hyperplasia, anti-inflammation and pro-endothelialization properties. This novel drug-delivery system may provide a breakthrough for the surface endothelialization of cardiovascular DES.

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Investigation of enhanced hemocompatibility and tissue compatibility associated with multi-functional coating based on hyaluronic acid and Type IV collagen

Cited by 28 publications

References 46 publications

Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility

Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility

Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix

Surface Modification of Cardiovascular Stent Material 316L SS with Estradiol-Loaded Poly (trimethylene carbonate) Film for Better Biocompatibility

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