Surface Modification of Cardiovascular Stent Material 316L SS with Estradiol-Loaded Poly (trimethylene carbonate) Film for Better Biocompatibility

Abstract

Abstract:A delay in the endothelialization process represents a bottleneck in the application of a drug-eluting stent (DES) during cardiovascular interventional therapy, which may lead to a high risk of late restenosis. In this study, we used a novel active drug, estradiol, which may contribute to surface endothelialization of a DES, and prepared an estradiol-loaded poly (trimethylene carbonate) film (PTMC-E5) on the surface of the DES material, 316L stainless steel (316L SS), in order to evaluate its function in improving surface endothelialization. All the in vitro and in vivo experiments indicated that the PTMC-E5 film significantly improved surface hemocompatibility and anti-hyperplasia, anti-inflammation and pro-endothelialization properties. This novel drug-delivery system may provide a breakthrough for the surface endothelialization of cardiovascular DES.

Effects of different polyaniline emeraldine compositions in electrodepositing ginsenoside encapsulated poly(lactic‐co‐glycolic acid) microcapsules coating: Physicochemical characterization and in vitro evaluation

“…As described in a study by Vickackaite and Ciuvasovaite (), the high ratio of molar concentration of monomer aniline to pyrrole could lead to inhomogeneous and delaminated coating. While in a view of surface roughness, rough stent surfaces will induce platelet adherence, thus subsequently initiate coagulation and thrombus formation (Xu et al, ; Yao et al, ). Rough stent surfaces will also prevent cell migration and complicating endothelialization (Douroumis & Onyesom, ).…”

Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer

“…The infrared absorption spectra of the SPS, SP and SA samples were gained using a Fourier transform infrared (FTIR, NICOLET 5700, Waltham, MA, USA) spectrometer in the scanning range of 4000–400 cm −1 after being freeze-dried, crushed, ground and tablet compressed with KBr [17]. The SPS, SP and SA hydrogel spheres were photographed with Huawei Mate 10 Pro camera equipment to directly observe their entire object and sizes, and their diameters were also detected from at least 100 spheres for each sample [18].…”

Conjugating heparin, Arg–Glu–Asp–Val peptide, and anti-CD34 to the silanic Mg–Zn–Y–Nd alloy for better endothelialization

“…31 The changes of surface chemical composition in each stage of sample preparation were recorded by Fourier transform infrared reflection (FTIR) spectrum, with the wavelength range of 4000-400 cm À1 . 32 Amine density on the BTSE-APTES, Hep, Hep/REDV, and Hep/REDV/ anti-CD34 samples was determined using a typical acid orange II colorimetric method. 33 The electrochemical properties of different samples were tested by using the RST5200 electrochemical workstation (Rhiruisi, Zheng Zhou): using the classic three electrode system, the saturated calomel electrode is the reference electrode, the 260 platinum electrode is the auxiliary electrode, and the sample to be tested is the working electrode.…”