Investigation of Epstein–Barr virus in breast carcinomas in Tunisia

Hachana, Mohamed Ridha; Amara, Khaled; Ziadi, Sonia; Romdhane, E.; Gacem, Riadh Ben; Trimèche, Mounir

doi:10.1016/j.prp.2011.09.007

Cited by 33 publications

(28 citation statements)

References 29 publications

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“…In addition, EBV infection was found in approximately 52% in breast cancer, which is similar to its presence in breast cancer in Middle Eastern women, based on Kalkan et al 20 , Zekri et al 21 and Hachana et al 22 studies. In parallel, we report that the presence of EBV in breast cancer is associated with more aggressive phenotype.…”

Section: Genesmentioning

confidence: 65%

“…Zekri et al 21 found that, 45% and 28% of breast cancer in Egyptian and Iraqi women, respectively, are positive for EBV. In parallel, Hachana et al 22 demonstrated that 27% of breast cancer tissues in Tunisia are positive for EBV. However, a recent study from Iran showed that EBV is not detectable in breast cancer and normal mammary tissues in Iranian women.…”

Section: Genesmentioning

confidence: 96%

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Incidence of Epstein–Barr virus in Syrian women with breast cancer: A tissue microarray study

Aboulkassim

Yasmeen

Akil

et al. 2015

Human Vaccines & Immunotherapeutics

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Keywords: breast cancer, Epstein-Barr virus, invasive cancer, Syrian women Epstein-Barr virus (EBV) has been recently shown to be present in human breast cancer worldwide, which could play an important role in the initiation and progression of this cancer. In this regard, we aimed to explore the prevalence of EBV in 108 breast cancer tissues from Syrian women using polymerase chain reaction (PCR) and tissue microarray (TMA) analysis. We found that EBV is present in 56 (51.85%) of breast cancers samples. Additionally, we report that the expression of LMP1 gene of EBV is associated with a cancer invasive phenotype in the majority of the cancer samples. These data imply that EBV is present in breast cancer worldwide including Syria and its presence is associated with more aggressive cancer phenotype. Thus, future investigations are needed to elucidate the exact role of EBV in breast carcinogenesis and metastasis.

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Section: Genesmentioning

confidence: 65%

Section: Genesmentioning

confidence: 96%

Incidence of Epstein–Barr virus in Syrian women with breast cancer: A tissue microarray study

Aboulkassim

Yasmeen

Akil

et al. 2015

Human Vaccines & Immunotherapeutics

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“…We did not use microdissection (which can cause virus levels to be too low to amplify) and used histologically normal cells with no visible signs of atypia, which meant that our study avoided some of the limitations of earlier studies. Only four previous studies have used paired breast cancer and normal breast tissue samples for PCR analysis of EBV[27, 32, 33] or CMV(13) and our study and one other[34] have included PCR analysis of both viruses in paired breast cancer and normal breast samples. To place our results in context, we undertook a comprehensive review of the existing literature on PCR studies of EBV and/or CMV and breast cancer, together with a meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Cytomegalovirus and Epstein-Barr Virus in Breast Cancer

et al. 2015

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Findings of polymerase chain reaction (PCR) studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) and breast cancer vary, making it difficult to determine whether either, both, or neither virus is causally associated with breast cancer. We investigated CMV and EBV in paired samples of breast cancer and normal breast tissue from 70 women using quantitative PCR. A serum sample from each woman was tested for CMV and EBV IgG. To place our results in context, we reviewed the existing literature and performed a meta-analysis of our results together with previous PCR studies of EBV, CMV, and breast cancer. Of the serology samples, 67 of 70 (96%) were EBV IgG positive and 49 of 70 (70%) were CMV IgG positive. QPCR detected EBV in 24 (34%) of the tumour and 9 (13%) of the paired normal specimens and CMV in 0 (0%) of the tumour and 2 (3%) of the paired normal specimens. Our findings, together with earlier results summarised in the meta-analysis, suggest several possibilities: variable findings may be due to limitations of molecular analyses; ‘hit and run’ oncogenesis may lead to inconsistent results; one or both viruses has a role at a later stage in breast cancer development; infection with multiple viruses increases breast cancer risk; or neither virus has a role. Future studies should focus on ways to investigate these possibilities, and should include comparisons of breast cancer tissue samples with appropriate normal tissue samples.

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“…2016; 11(3):e34806. (11,18,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53). Table 1 shows a summary of the EBV-DNA positive subjects according to nationality, types of sample, and kinds of control tissue in the 20 selected studies.…”

Section: Resultsmentioning

confidence: 99%

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Bae

Kim

2016

Arch Clin Infect Dis

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Context: The association between 'Epstein-Barr' virus (EBV) and breast cancer risk still remains controversial. A Systemic Review (SR) published in 2012 reported that there might be a statistically significant association between EBV and risk of breast cancer. However, errors were found in the appraisal process of the concerned SR. Objectives:The aim of this report was to conduct an adaptive meta-analysis with additional extraction of relevant papers published up until September 2015.Data Sources: The lists of references, cited articles and related articles provided by PubMed were made using the articles selected in the previous SR.Study Selection: Among these articles, only case-control studies using Polymerase Chain Reaction (PCR) techniques to detect EBV DNA in tissues were selected. Data Extraction: The summary odds ratio (SOR) and the 95% confidence interval (CI) were calculated though meta-analysis.Results: A total of 20 case-control studies were selected, and the total numbers of subjects in the case and control groups were 1947 and 1010, respectively. The findings of this meta-analysis revealed that EBV infection might increase the risk of breast cancer (SOR = 3.84, 95% CI: 2.24-6.58; I-squared = 62.2%). Sub-group analyses by region, sample type, and control tissue showed that a statistical significance of the risk was still secured. Conclusions:The findings of the meta-epidemiological study support that EBV infection may increase the risk of breast cancer. Nested case-control studies are required in the future.

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Investigation of Epstein–Barr virus in breast carcinomas in Tunisia

Cited by 33 publications

References 29 publications

Incidence of Epstein–Barr virus in Syrian women with breast cancer: A tissue microarray study

Incidence of Epstein–Barr virus in Syrian women with breast cancer: A tissue microarray study

Cytomegalovirus and Epstein-Barr Virus in Breast Cancer

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

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