Investigation of hemorheological parameters at the diagnosis and follow up of children with iron deficiency anemia and mixed anemia

Isik-Balci, Yasemin; Tancer-Elci, Hazal; Bor-Küçükatay, Melek; Kilic-Erkek, Ozgen; Kilic‐Toprak, Emine; Şenol, Hande; Rota, Simin

doi:10.3233/ch-141811

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Utilizing capillary-driven auto-mixing in a 3D-printed microfluidic mixer, we developed a color-scale assay for POC diagnosis and self-management of anemia. Hemoglobin (Hgb) level is the primary laboratory parameter for the clinical diagnosis of anemia[47]. The current gold standard is a complete blood count (CBC) using a hematology analyzer via venous blood, which requires a blood draw by a trained phlebotomist and needs electrical power to operate in centralized hospitals or clinics[48].…”

Section: Resultsmentioning

confidence: 99%

3D printed microfluidic mixer for point-of-care diagnosis of anemia

Plevniak

Campbell

2016

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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3D printing has been an emerging fabrication tool in prototyping and manufacturing. We demonstrated a 3D microfluidic simulation guided computer design and 3D printer prototyping for quick turnaround development of microfluidic 3D mixers, which allows fast self-mixing of reagents with blood through capillary force. Combined with smartphone, the point-of-care diagnosis of anemia from finger-prick blood has been successfully implemented and showed consistent results with clinical measurements. Capable of 3D fabrication flexibility and smartphone compatibility, this work presents a novel diagnostic strategy for advancing personalized medicine and mobile healthcare.

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Section: Resultsmentioning

confidence: 99%

3D printed microfluidic mixer for point-of-care diagnosis of anemia

Plevniak

Campbell

2016

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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“…Hemoglobin (Hgb) level is the primary laboratory parameter for the clinical diagnosis of anemia. 47 The current gold standard is a complete blood count (CBC) using a hematology analyzer via venous blood, which requires a blood draw by a trained phlebotomist and needs electrical power to operate in centralized hospitals or clinics. 48 Several portable devices for anemia diagnosis have been developed, 49,50 such as HemoCue-B Hemoglobin, 51 STAT-Site V R MHgb, 52 Rainbow V R signal extraction technology (SET), and SpectOLight TM Occlusion.…”

Section: Rapid Poc Diagnosis Of Anemiamentioning

confidence: 99%

3D printed auto-mixing chip enables rapid smartphone diagnosis of anemia

et al. 2016

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Clinical diagnosis requiring central facilities and site visits can be burdensome for patients in resource-limited or rural areas. Therefore, development of a lowcost test that utilizes smartphone data collection and transmission would beneficially enable disease self-management and point-of-care (POC) diagnosis. In this paper, we introduce a low-cost iPOC 3D diagnostic strategy which integrates 3D design and printing of microfluidic POC device with smartphone-based disease diagnosis in one process as a stand-alone system, offering strong adaptability for establishing diagnostic capacity in resource-limited areas and low-income countries. We employ smartphone output (AutoCAD 360 app) and readout (color-scale analytical app written in-house) functionalities for rapid 3D printing of microfluidic auto-mixers and colorimetric detection of blood hemoglobin levels. The automixing of reagents with blood via capillary force has been demonstrated in 1 second without the requirement of external pumps. We employed this iPOC 3D system for point-of-care diagnosis of anemia using a training set of patients (n anemia ¼ 16 and n healthy ¼ 6), which showed consistent measurements of blood hemoglobin levels (a.u.c. ¼ 0.97) and comparable diagnostic sensitivity and specificity, compared with standard clinical hematology analyzer. Capable of 3D fabrication flexibility and smartphone compatibility, this work presents a novel diagnostic strategy for advancing personalized medicine and mobile healthcare. Published by AIP Publishing. [http://dx

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Erythrocyte deformability reduction in various pediatric hematologic diseases

Kim

Lim

Suh

et al. 2020

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BACKGROUND: Previously, hemorheology studies using Rheoscan mainly focused on chronic kidney disease, cardiovascular disease, and endocrine disease in adults. The study using LORCA focused on erythrocyte disease. There were no studies using Rheoscan in children. OBJECTIVE: We aimed to investigate erythrocyte deformability among various hematologic diseases occurring in children, namely, iron deficiency anemia (IDA), hereditary spherocytosis (HS), immune thrombocytopenia (ITP), and aplastic anemia (AA). METHODS: Differences between those with HS, IDA, ITP, AA and healthy controls were compared among 43 patients, comprising 7 patients with HS, 8 patients with IDA, 6 patients with AA, 9 patients with ITP, and 13 healthy controls. Erythrocyte deformability was measured using a microfluidic ektacytometer (RheoScan-D, RheoMeditech, Seoul, Korea). The erythrocyte elongation index (EI) was defined as (L – W)/(L + W), where L and W are the major and minor axes of the ellipse, respectively. RESULTS: The EI values of IDA, HS and AA were significantly decreased compared with healthy controls, but those of ITP were similar to healthy controls. CONCLUSIONS: This study showed that erythrocyte deformability differed among various hematologic diseases. Further study concerning correlation in relation to the diagnostic and prognostic significance of erythrocyte deformability in hematologic disease is needed.

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Investigation of hemorheological parameters at the diagnosis and follow up of children with iron deficiency anemia and mixed anemia

Cited by 3 publications

References 9 publications

3D printed microfluidic mixer for point-of-care diagnosis of anemia

3D printed microfluidic mixer for point-of-care diagnosis of anemia

3D printed auto-mixing chip enables rapid smartphone diagnosis of anemia

Erythrocyte deformability reduction in various pediatric hematologic diseases

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