Investigation of High-Sensitivity C-reactive Protein and Erythrocyte Sedimentation Rate in Low Back Pain Patients

Park, Chan Hong; Lee, Sang Ho

doi:10.3344/kjp.2010.23.2.147

Cited by 26 publications

(26 citation statements)

References 13 publications

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“…CRP-an acute phase reactant is an indicator of low grade inflammation. The higher level in our cases denotes the probable role of inflammation in back pain [25].…”

Section: Discussionmentioning

confidence: 50%

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

et al. 2014

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Low back pain is very disabling and dispiriting because of the physical impediment it causes and its psychological effects. Innumerable factors have been implicated in its etiology. In spite of improvements in diagnostic modalities, a considerable number of such cases fall in the ambiguous zone of unknown etiology or 'idiopathic.'Early diagnosis of low back pain will allow effective prevention and treatment to be offered. This study was conducted to assess the contribution of vitamin D levels and other biochemical factors to chronic low back pain in such cases. All patients attending the orthopedics OPD for low back pain in whom a precise anatomical cause could not be localized, were prospectively enrolled in this study. We measured serum levels of glucose, calcium, phosphorus, uric acid, rheumatoid factor, C reactive protein, alkaline phosphatase, total protein, albumin and 25 (OH) D concentrations in 200 cases and 200 control samples. The patients showed significantly lower vitamin D levels compared to controls with p value \ 0.0001. The maximum number of low back pain patients were in the age group of 31-50 years (42 %).The average BMI was 23.27 ± 5.17 kg/sq m, 73 % of total patient population were females and 27 % were known case of type 2 diabetes mellitus. Calcium, alkaline phosphatase, was positively correlated with vitamin D and glucose showed a negative correlation with vitamin D in the patient population. The problem of low back pain provides a challenge to health care providers. The problem in developing countries is compounded by ignorance to report for early treatment and occupational compulsions in rural areas and sedentary lifestyle in urban youth. The authors strongly recommend early frequent screening for vitamin D along with glucose, protein, albumin, calcium, phosphorus, CRP as part of general health checkup for non-specific body pain, especially low back pain.

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“…CRP-an acute phase reactant is an indicator of low grade inflammation. The higher level in our cases denotes the probable role of inflammation in back pain [25].…”

Section: Discussionmentioning

confidence: 50%

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

et al. 2014

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“…We considered that the pathophysiology of LSS is complex [2], and although mechanical compression of the nerve root is a major factor, inflammatory effects [19] and some other causes, such as depression and the subjective quality of feeling, also affect both pain intensity and unpleasantness [20].…”

Section: Discussionmentioning

confidence: 99%

Clinical symptoms of lumbar spinal stenosis associated with morphological parameters on magnetic resonance images

et al. 2015

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“…However, only one study could be found concerning patients with chronic lumbar pain and radicular pain. In another study, CRP and ESR levels were expected to increase dependent on increased inflammatory reactions, but they did not increase (7).…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory measurements of acute phase proteins are important indicators for the degree of inflammation and response to treatment. CRP is a sensitive marker of inflammation and tissue damage, but erythrocyte sedimentation rate (ESR) is not a specific marker (7).…”

Section: Introductionmentioning

confidence: 99%

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

Pirbudak¹,

Çiçek²,

Işık³

et al. 2015

Turk J Med Sci

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Background/aim: To compare the effects of tramadol-only treatment and tramadol + gabapentin treatment in patients who had received an epidural steroid injection. Materials and methods:Forty patients with hernia disc-originated acute lumbar discogenic pain were evaluated. All patients received a single dose of steroid and local anesthesia mixture epidurally via the lumbar approach. In both groups, Group T (tramadol, n = 20) and Group TG (tramadol + gabapentin, n = 20), the injection dose was adjusted to 4 mL of triamcinolone acetonide and 0.25% bupivacaine mixture. Orally, 75 mg/day tramadol or 75 mg/day tramadol + 900 mg/day gabapentin were added to the treatment. Leukocyte, erythrocyte sedimentation rate, C-reactive protein, and urine serotonin levels were measured prior to and after treatment. The effectiveness of the treatment was evaluated by visual analog scale (VAS), Oswestry Disability Index (ODI), and straight leg elevation test (SLET).Results: Similar improvements in VAS, ODI, and SLET values were observed in both groups in the second week. The inflammation markers were not different after treatment, neither within the groups nor between the groups. Conclusion:This study revealed that tramadol + gabapentin treatment was not superior to tramadol treatment.

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Investigation of High-Sensitivity C-reactive Protein and Erythrocyte Sedimentation Rate in Low Back Pain Patients

Cited by 26 publications

References 13 publications

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

Clinical symptoms of lumbar spinal stenosis associated with morphological parameters on magnetic resonance images

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

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