Investigation of HIV-1 Primary Drug Resistance Mutations in Antiretroviral Therapy-Naive Cases

Yalçinkaya, Tülay; Köse, Şükran

doi:10.5578/mb.8321

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Current data showed that half of HIV-infected patients present late in Turkey. In recently diagnosed patient cohorts, mean (or median in some studies) CD4 counts were reported in a range of 236 to 441/mm 3 (Table 4) (19)(20)(21)(22)(23)(24). In the first analysis of late presenters in the country, we noted that late presenters corresponded to 66% of 209 newly diagnosed HIV-positive individuals (13).…”

Section: Discussionmentioning

confidence: 93%

Late presentation among patients with human immunodeficiency virus infection in Turkey

Karaosmanoğlu¹,

Mete²,

Gündüz

et al. 2019

Cent Eur J Public Health

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Objective: Late presentation of the patients with human immunodeficiency virus (HIV) infection is associated with less favourable treatment responses, more accelerated clinical progression, and a higher mortality risk. Although HIV prevalence is low in Turkey, it is steadily increasing and the information about late presentation among HIV-positives is limited. We aimed to analyze the status of late presentation among HIV-positive patients in Turkey. Methods: All newly diagnosed HIV/AIDS patients from 2003 to 2016 were enrolled in this study by five dedicated centres in Istanbul, Turkey. Demographic data, CD4+ counts, and HIV RNA were collected from medical records and were transferred to a HIV database system. Late presentation was defined as presentation for care with a CD4 count < 350 cells/mm 3 or presentation with an AIDS-defining event, regardless of the CD4 cell count. A medical literature search was done for the analysis of late presentation in Turkey. Results: The cohort included 1,673 patients (1,440 males, median age 35 years). Among them, 847 (50.6%) had an early diagnosis, with a CD count of more than 350 cells/mm 3. The remaining 826 were late presenters. Among late presenters, 427 (25.5% of all, 51.7% of late presenters) presented with advanced HIV disease. Late presenters were more elderly and less educated. The gender seemed comparable between groups. Late presentation was more likely among married patients. Early presenters were more likely among homosexuals, those diagnosed in screening studies, and in lower HIV-RNA viral load category. There has been a decreasing trend among late presenters in 2011-2016 when compared to 2003-2011 period. Conclusion: Current data suggest that half of HIV-infected patients present late in Turkey. In our cohort, those presented late were more elderly, less educated, married and had heterosexual intercourse. On admission, late presenters had more HIV-related diseases and were more likely in higher HIV-RNA category. In the cohort, men having sex with men were less likely late presenters. Efforts to reduce the proportion of late presentation are essential for almost every country. The countries should identify the risk factors of late presentation and should improve early diagnosis and presentation for HIV care.

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Section: Discussionmentioning

confidence: 93%

Late presentation among patients with human immunodeficiency virus infection in Turkey

Karaosmanoğlu¹,

Mete²,

Gündüz

et al. 2019

Cent Eur J Public Health

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“…In Spain; a study stated that the prevalence was 5.8 % for NRTI, 5 % for NNRTI and 3.8 % for PI [6]. In Turkey; a study stated that the percentage of HIV-1 primary drug resistance mutations, in antiretroviral therapy-naive patients, was 5.2 % for NRTI, 3.1 % for NNRTI and 2.1 % for PI [7]. In Djibouti; a study indicated that among 16 patients with first-line ART failure, 56.2 % showed reverse transcriptase inhibitor-resistant HIV-1 strains.…”

Section: Genementioning

confidence: 99%

Mathematical Analysis of the Probability of Spontaneous Mutations in HIV-1 Genome and Their Role in the Emergence of Resistance to Anti-Retroviral Therapy

Abbas¹

2019

AiM

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“…Direnç gelişiminin önlenmesi ve değerlendirilmesi için gelişmemiş ya da gelişmekte olan ülkelerde de bazal direnç bakılması önerilmektedir. Ülkemizde Yalçınkaya ve Köse (36) yaptıkları çalışmada, tedavi almamış olgularda ilaç direnç oranını %10 olarak belirlemişlerdir. Kuşkucu ve ark.…”

Section: İlaç Direnci Testleriunclassified

Current Diagnostic Algorithm of HIV and Emerging Prevention Methods

Aslan¹,

Altındiş²

2017

TMCD

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Investigation of HIV-1 Primary Drug Resistance Mutations in Antiretroviral Therapy-Naive Cases

Cited by 5 publications

References 8 publications

Late presentation among patients with human immunodeficiency virus infection in Turkey

Late presentation among patients with human immunodeficiency virus infection in Turkey

Mathematical Analysis of the Probability of Spontaneous Mutations in HIV-1 Genome and Their Role in the Emergence of Resistance to Anti-Retroviral Therapy

Current Diagnostic Algorithm of HIV and Emerging Prevention Methods

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