2018
DOI: 10.1016/j.foodchem.2018.01.187
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Investigation of interaction modes involved in alkaline phosphatase and organophosphorus pesticides via molecular simulations

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Cited by 45 publications
(15 citation statements)
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“…Analysis of transcriptomic data to identify which genes are upregulated by exposure to 50 mg L −1 of phoxim for 24 h enabled putative OP degradation genes to be identified (Table 3). This confirmed that transcription of the genes for various hydrolases was significantly enhanced, which corresponded with previously reported hydrolytic degradation of OPs [31,32,33,34,35]. Most significantly, the upgraded genes included two different alkaline phosphatases, which corresponded with the known ability of AP3 from YP6 to cleave the P-aminooxy bond of phoxim [23].…”
Section: Resultssupporting
confidence: 89%
“…Analysis of transcriptomic data to identify which genes are upregulated by exposure to 50 mg L −1 of phoxim for 24 h enabled putative OP degradation genes to be identified (Table 3). This confirmed that transcription of the genes for various hydrolases was significantly enhanced, which corresponded with previously reported hydrolytic degradation of OPs [31,32,33,34,35]. Most significantly, the upgraded genes included two different alkaline phosphatases, which corresponded with the known ability of AP3 from YP6 to cleave the P-aminooxy bond of phoxim [23].…”
Section: Resultssupporting
confidence: 89%
“…37 The key amino acids that facilitate the formation of hydrogen bonds between pesticides and the ALP were as Gln375, Asp55 or Thr413. 38 Binding of the Zn 2+ and Cu 2+ in the active site might impede the hydrogen bonds.…”
Section: Effects Of Edta and Metal Ions On Alp Activitymentioning
confidence: 99%
“…guanacastense JP-NJ2 has phosphatase high-activity, which had a dominant role in its phosphate-solubilizing action. The degradation of lecithin depends on the role of acid phosphatase (Mehra et al, 2017), and alkaline phosphatase activity has a great effect on the degradation of organophosphorus pesticides (Chu et al, 2018). In addition, P .…”
Section: Discussionmentioning
confidence: 99%