Investigation of local white matter abnormality in Parkinson’s disease by using an automatic fiber tract parcellation

Wang, Jingqiang; Zhang, Fan; Zhao, Changchen; Zeng, Qingrun; He, Jianzhong; O’Donnell, Lauren J.; Feng, Yuanjing

doi:10.1016/j.bbr.2020.112805

Cited by 15 publications

(6 citation statements)

References 68 publications

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“…The cingulum was mainly associated with the memory and general function, the corpus callosum and superior longitudinal fasciculus mainly participated in the executive function, the corpus callosum was also related to the attention and processing speed ( Zhang et al, 2019 ; Zhu et al, 2019 ). Moreover, decrease of FA in the superior longitudinal fasciculus, cingulum, and corpus callosum was also identified in the Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease and other neurodegenerative diseases and correlated with worse cognitive function in these diseases ( Hulst et al, 2013 ; Zhang et al, 2016 ; Lo Buono et al, 2020 ; Wang et al, 2020 ; Chenji et al, 2021 ). In our study, the specific fiber tracts identified to correlate with the cognitive function in the correlation tractography, was in line with the findings in previous studies.…”

Section: Discussionmentioning

confidence: 91%

Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study

Yeh

Huang

et al. 2022

Front. Hum. Neurosci.

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Differential tractography and correlation tractography are new tractography modalities to study neuronal changes in brain diseases, but their performances in detecting neuronal injuries are yet to be investigated in patients with mild traumatic brain injury (mTBI). Here we investigated the white matter injury in mTBI patients using differential and correlation tractography. The diffusion MRI was acquired at 33 mTBI patients and 31 health controls. 7 of the mTBI patients had one-year follow-up scans, and differential tractography was used to evaluate injured fiber bundles on these 7 patients. All subjects were evaluated using digital symbol substitution test (DSST) and trail making test A (TMT-A), and the correlation tractography was performed to explore the exact pathways related to the cognitive performance. Our results showed that differential tractography revealed neuronal changes in the corpus callosum in all 7 follow-up mTBI patients with FDR between 0.007 and 0.17. Further, the correlation tractography showed that the splenium of the corpus callosum, combined with the right superior longitudinal fasciculus and right cingulum, were correlated with DSST (FDR = 0.001669) in the acute mTBI patients. The cognitive impairment findings in the acute stage and the longitudinal findings in the corpus callosum in the chronic stage of mTBI patients suggest that differential tractography and correlation tractography are valuable tools in the diagnostic and prognostic evaluation of neuronal injuries in mTBI patients.

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Section: Discussionmentioning

confidence: 91%

Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study

Yeh

Huang

et al. 2022

Front. Hum. Neurosci.

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“…We assessed the diffusion properties of FA, MD, RD, and AD along with the clusters and conducted group‐wise unpaired t ‐tests for p ‐values corrected by the FDR method. In addition, we conducted Pearson's correlation analysis between the clinical indices (DDT and DCL) and diffusion properties in each node 42 . The diffusion parameters of clusters were considered to show relevance with clinical indices when the p ‐values were less than 0.05 and the R ‐values were greater than 0.3.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, we conducted Pearson's correlation analysis between the clinical indices (DDT and DCL) and diffusion properties in each node. 42 The diffusion parameters of clusters were considered to show relevance with clinical indices when the p-values were less than 0.05 and the R-values were greater than 0.3. Fibers that reached the WM and gray matter junctions were susceptible to low anisotropy and ambiguous termination conditions.…”

Section: Tractometric Analysismentioning

confidence: 99%

Alterations of white matter tracts and topological properties of structural networks in hemifacial spasm

et al. 2022

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Hemifacial spasm (HFS) is characterized by involuntary and paroxysmal muscle contractions on the hemiface. It is generally believed that HFS is caused by neurovascular compression at the root exit zone of the facial nerve. In recent years, the structural alterations of brains with HFS have aroused growing concern. However, little attention has been directed towards the possible involvement of specific white matter (WM) tracts and the topological properties of structural networks in HFS. In the present study, diffusion magnetic resonance imaging tractography was utilized to construct structural networks and perform tractometric analysis. The diffusion tensor imaging scalar parameters along with the WM tracts, and the topological parameters of global networks and subnetworks, were assessed in 62 HFS patients and 57 demographically matched healthy controls (HCs). Moreover, we investigated the correlation of these parameters with disease‐clinical‐level (DCL) and disease‐duration‐time (DDT) of HFS patients. Compared with HCs, HFS patients had additional hub regions including the amygdala, ventromedial putamen, lateral occipital cortex, and rostral cuneus gyrus. Furthermore, HFS patients showed significant alternations with specific topological properties in some structural subnetworks, including the limbic, default mode, dorsal attention, somato‐motor, and control networks, as well as diffusion properties in some WM tracts, including the superior longitudinal fasciculus, cingulum bundle, thalamo‐frontal, and corpus callosum. These subnetworks and tracts were associated with the regulation of emotion, motor function, vision, and attention. Notably, we also found that the parameters with subnetworks and tracts exhibited correlations with DCL and DDT. In addition to corroborating previous findings in HFS, this study demonstrates the changed microstructures in specific locations along with the fiber tracts and changed topological properties in structural subnetworks.

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“…This method is significantly improved compared to previous automated fiber tracking methods, which can only extract the main fiber tracts, failing to cover the entire brain's white matter (i.e., including the cerebellum and superficial tracts). In addition, it was successfully applied in several recent studies [85][86][87][88][89][90][91][92][93][94], demonstrating high test-retest reproducibility [95] and robustness to anatomical variability [96].…”

Section: Wm Fiber Clusteringmentioning

confidence: 99%

Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury

Rojczyk

Seitz-Holland

Kaufmann

et al. 2023

JCM

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Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI have been linked to alterations in white matter (WM) microstructure, but whether poor sleep quality has a compounding effect on WM remains largely unknown. We evaluated sleep and diffusion magnetic resonance imaging (dMRI) data from 180 male post-9/11 veterans diagnosed with (1) PTSD (n = 38), (2) mTBI (n = 25), (3) comorbid PTSD+mTBI (n = 94), and (4) a control group with neither PTSD nor mTBI (n = 23). We compared sleep quality (Pittsburgh Sleep Quality Index, PSQI) between groups using ANCOVAs and calculated regression and mediation models to assess associations between PTSD, mTBI, sleep quality, and WM. Veterans with PTSD and comorbid PTSD+mTBI reported poorer sleep quality than those with mTBI or no history of PTSD or mTBI (p = 0.012 to <0.001). Poor sleep quality was associated with abnormal WM microstructure in veterans with comorbid PTSD+mTBI (p < 0.001). Most importantly, poor sleep quality fully mediated the association between greater PTSD symptom severity and impaired WM microstructure (p < 0.001). Our findings highlight the significant impact of sleep disturbances on brain health in veterans with PTSD+mTBI, calling for sleep-targeted interventions.

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Investigation of local white matter abnormality in Parkinson’s disease by using an automatic fiber tract parcellation

Cited by 15 publications

References 68 publications

Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study

Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study

Alterations of white matter tracts and topological properties of structural networks in hemifacial spasm

Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury

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