Investigation of Micellar and Phase Separation Phenomenon of the Amphiphilic Drug Amitriptyline Hydrochloride with Cationic Hydrotropes

Rub, Malik Abdul; Asiri, Abdullah M.; Khan, Aftab Aslam Parwaz; Azum, Naved; Khan, Sher Bahadar; Kabir-ud-Din, †

doi:10.1007/s10953-013-9964-2

Cited by 23 publications

(8 citation statements)

References 35 publications

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“…In this context, the binding constants of drugs to micelles can be quantitatively determined using the simple mathematical model known as the Benesi–Hildebrand equation based on the Beer–Lambert law valid in the high micelle concentration region (Benesi and Hildebrand, ). In spite of many reports on the interactions between drugs and conventional surfactants in the literature (Azum et al, , ; Cai et al, ; Chauhan et al, ; Enache and Volanschi, ; Hanif et al, ; Hossain and Hoque, ; Kabir‐ud‐Din et al, ; Kaushal et al, ; Khan et al, ; Khan and Shah, ; Lazaro et al, ; Mukhija and Kishore, ; Naqvi et al, ; Noori et al, ; Rub et al, , , ; Sharma and Jani, ; Ullah et al, ), there is limited number of studies that combine spectroscopy with surface tension measurements or conductometry for the understanding of the mechanism of these types of interactions (Ali et al, ; Ansari et al, ; Gokturk et al, ; Kabir‐ud‐Din et al, , ; Maswal et al, ; Rub et al, ). Previously, we reported a study on the binding characteristics of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in the presence of sodium dodecyl sulfate (SDS) and Triton X‐100 (TX‐100) micelles employing spectroscopy and surface tension measurements.…”

Section: Introductionmentioning

confidence: 99%

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Göktürk

TAMER

2018

J Surfact & Detergents

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Absorption spectroscopy, conductivity, and surface tension measurements were carried out at 298 K to study the solubilization of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in Aerosol‐OT (AOT) micellar media. The binding constants of SMX and TMP to AOT micelles were determined by applying the Benesi–Hildebrand equation. A comparison of the binding constants indicates that the binding tendency of TMP with AOT micelles is higher than that of SMX. To better analyze the incorporation of drugs into anionic AOT micellar media, surface tension measurements were performed in the presence of SMX and TMP in aqueous media. The influence of TMP and SMX on the surface properties of AOT was determined using the Gibbs Adsorption Isotherm. Changes in the surface properties of AOT determined by surface tension measurements in the presence of drugs are in good agreement with the binding constants determined spectrophotometrically. Calculated surface parameters indicate higher incorporation of TMP with AOT than that of SMX. Comparison of the aqueous solubility of TMP and SMX with micellar media indicated solubility enhancements for both poorly soluble drugs. A special attempt was made to highlight simultaneous interactions of TMP and SMX with AOT using both surface tension and conductometric measurements that can be used to determine counterion‐binding parameters.

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Section: Introductionmentioning

confidence: 99%

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Göktürk

TAMER

2018

J Surfact & Detergents

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“…[11] Here, we used conductometric measurements to determine the CMC of drug-anionic surfactant (sodium bis (2-ethylhexyl)sulfosuccinate (AOT)) binary systems toward the detailed characterization of physicochemical properties of drug=anionic surfactants systems. There are several reports on the micellization and clouding behavior of amphiphilic drugs that have been published by our groups earlier [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] with most of them being either cationiccationic or cationic-nonionic interactions; however, in the second paper by our group, we have reported the cationic drug (PMT)-anionic surfactant (AOT) interactions at different temperatures and compositions. The tendency of the drug and AOT to form mixed micelles in aqueous form is governed by their synergistic or repulsive interactions and is often explained by the interaction parameter estimated using Rubingh's regular solution theory.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Amphiphilic Drug and Anionic Surfactant Mixtures: Experimental and Theoretical Approach

Rub

Azum

Khan

et al. 2014

Journal of Dispersion Science and Technology

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Herein, we have reported the mixed micelle formation of amphiphilic phenothiazine drug promethazine hydrochloride (PMT) and anionic surfactant sodium bis(2-ethylhexyl)sulfosuccinate (AOT) mixtures at different compositions and temperatures (288.15, 293.15, 298.15, 303.15, and 308.15 K). A conductometric method is used to evaluate the critical micelle concentration (CMC) of binary mixtures. An attractive interaction between PMT and AOT mixed systems was indicated by the experimental and ideal critical micelle concentration (CMC and CMC id ) values. The micellar mole fraction of anionic surfactant (X Rub 1 , X M 1 , X Rod 1 , and X id 1 ) was evaluated by different proposed models, and they prove the greater contribution of AOT in mixed micelle and increase with the increase in AOT concentration. Activity coefficients (f 1 and f 2 ) calculated by all recommended models were found to be always less than unity, signifying nonideality in the mixed systems. Different thermodynamic parameters have also been evaluated using the respective CMC values as a function of temperature. DG m values were always found to be negative for all the systems; however, DH m for pure drug as well as PMT-AOT mixed systems is negative at lower temperatures and positive at higher temperatures. The DS m values are positive at all temperatures but their magnitude is higher at T ¼ 303.15 K and above.

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“…These negative values decrease with the incresing concentration of AS. Rub et al found negative values of Δ H c 0 and Δ S c 0 for some amphilic drugs in the presence of Tw 80 and also in the presence of other additive mixed systems. ,− Negative Δ H c 0 and Δ S c 0 were also noticed earlier with respect to the phase-separation characteristics of many nonionic surfactant systems in water and in the presence of sodium chloride . The negative Δ H c 0 values indicate an exothermic process.…”

Section: Resultsmentioning

confidence: 90%

Influence of Different Additives on the Clouding Nature and Thermodynamic Behavior of Tween 80 Solution in the Absence and Presence of the Amikacin Sulfate Drug

et al. 2019

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Herein, the cloud-point (CP) measurements of a nonionic surfaceactive agent named Tween 80 [poly(oxyethylene) (20) sorbitanmonooleate; Tw 80] were carried out in this study in the absence and attendance of an amikacin sulfate (AS) drug/(AS+ inorganic electrolyte (NaCl, NaNO 3 and Na 2 SO 4 )). AS drug has been utilized to treat or prevent a wide range of bacterial infections. The measured values of CP in the aqueous phase for Tw 80 were observed in decreasing fashion with an increase in the concentration of surfactant. The obtained values of CP for Tw 80 solution were also noticed to decrease with increasing drug concentration. The determined CP values for (surfactant + drug) mixture were observed to decrease for the electrolytes' participation with respect to their nonparticipation, and the presence of electrolytes (sodium salts) in declining CP measurement was recorded and followed the order NaCl > NaNO 3 > Na 2 SO 4 . The ΔG c 0 values are found to be positive that denotes the character of clouding is nonspontaneous. The ΔH c 0 and ΔS c 0 calculations were shown to be negative for the system studied except for the (Tw 80 + H 2 O) phase. The negative values of ΔH c 0 and ΔS c 0 decreased with the increment of electrolyte concentration. The thermodynamic parameters of transfer for the studied system were also evaluated and are illustrated in detail.

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Investigation of Micellar and Phase Separation Phenomenon of the Amphiphilic Drug Amitriptyline Hydrochloride with Cationic Hydrotropes

Cited by 23 publications

References 35 publications

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Physicochemical Properties of Amphiphilic Drug and Anionic Surfactant Mixtures: Experimental and Theoretical Approach

Influence of Different Additives on the Clouding Nature and Thermodynamic Behavior of Tween 80 Solution in the Absence and Presence of the Amikacin Sulfate Drug

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