Investigation of moxifloxacin loaded chitosan-dextran nanoparticles for topical instillation into eye: In-vitro and ex-vivo evaluation

Kaskoos, Raad A

doi:10.4103/2230-973x.143114

Cited by 41 publications

(10 citation statements)

References 39 publications

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“…The morphology of these vesicles is depicted in Figure 3 A–C, respectively. Previously, Kaskoos (2014) reported the size of moxifloxacin-loaded chitosan–dextran nanoparticles as 279.18 nm, with a good polydispersity index of 0.367 [ 25 ]. In another study, Sohrabi et al (2016) reported the size of chitosan gel-embedded moxifloxacin niosomes to be around 290 nm [ 26 ], suggesting that this formulation has a small size and will show a good therapeutic response in vitro and in vivo.…”

Section: Resultsmentioning

confidence: 99%

Moxifloxacin and Sulfamethoxazole-Based Nanocarriers Exhibit Potent Antibacterial Activities

et al. 2021

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Antibiotic resistance is a major concern given the rapid emergence of multiple-drug-resistant bacteria compared to the discovery of novel antibacterials. An alternative strategy is enhancing the existing available drugs. Nanomedicine has emerged as an exciting area of research, showing promise in the enhanced development of existing antimicrobials. Herein, we synthesized nanocarriers and loaded these with available clinically approved drugs, namely Moxifloxacin and Sulfamethoxazole. Bactericidal activity against Gram-negative (Serratia marcescens, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella enterica) and Gram-positive (methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Bacillus cereus) bacteria was investigated. To characterize the nanocarriers and their drug-loaded forms, Fourier-transform infrared spectroscopy, dynamic light scattering, and atomic force microscopy were utilized. Antibacterial assays and hemolysis assays were carried out. Moreover, lactate dehydrogenase assays were performed to determine cytotoxicity against human cells. The results depicted the successful formation of drug–nanocarrier complexes. The potent antibacterial activities of the drug-loaded nanocarriers were observed and were significantly enhanced in comparison to the drugs alone. Hemolysis and cytotoxicity assays revealed minimal or negligible cytotoxic effects against human red blood cells and human cells. Overall, metronidazole-based nanocarriers loaded with Moxifloxacin and Sulfamethoxazole showed enhanced bactericidal effects against multiple-drug-resistant bacteria compared with drugs alone, without affecting human cells. Our findings show that drug-loaded nanocarriers hold promise as potent chemotherapeutic drugs against multiple-drug-resistant bacteria.

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Section: Resultsmentioning

confidence: 99%

Moxifloxacin and Sulfamethoxazole-Based Nanocarriers Exhibit Potent Antibacterial Activities

et al. 2021

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“…They observed an efficient NPs distribution in lens and retina. Similarly, chitosan-dextran NPs have been employed to deliver the antibiotic moxifloxacin that has been retained for a long time in vivo thanks to the mucoadhesive properties of NPs [132].…”

Section: Natural Hydrogels: Chitosan Nps (Chnps)mentioning

confidence: 99%

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Matteis

Rizzello

2020

Cells

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We are witnessing an exponential increase in the use of different nanomaterials in a plethora of biomedical fields. We are all aware of how nanoparticles (NPs) have influenced and revolutionized the way we supply drugs or how to use them as therapeutic agents thanks to their tunable physico-chemical properties. However, there is still a niche of applications where NP have not yet been widely explored. This is the field of ocular delivery and NP-based therapy, which characterizes the topic of the current review. In particular, many efforts are being made to develop nanosystems capable of reaching deeper sections of the eye such as the retina. Particular attention will be given here to noble metal (gold and silver), and to polymeric nanoparticles, systems consisting of lipid bilayers such as liposomes or vesicles based on nonionic surfactant. We will report here the most relevant literature on the use of different types of NPs for an efficient delivery of drugs and bio-macromolecules to the eyes or as active therapeutic tools.

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“…The authors conclude that this suspension was more effective than the commercially marketed product MoxiGram ® . MX antibiotic was also encapsulated into Ch–dextran sulfate (DS) NPs [ 18 ] and the efficiency of the formulation was tested in vitro and ex vivo against S. aureus and P. aeruginosa . The results revealed that the use of NPs exhibits a prolonged drug release profile with significantly high transcorneal permeation and high corneal retention.…”

Section: Areas Of Applicationmentioning

confidence: 99%

Antimicrobial Polymers in the Nano-World

2017

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Infections are one of the main concerns of our era due to antibiotic-resistant infections and the increasing costs in the health-care sector. Within this context, antimicrobial polymers present a great alternative to combat these problems since their mechanisms of action differ from those of antibiotics. Therefore, the microorganisms’ resistance to these polymeric materials is avoided. Antimicrobial polymers are not only applied in the health-care sector, they are also used in many other areas. This review presents different strategies that combine nanoscience and nanotechnology in the polymer world to combat contaminations from bacteria, fungi or algae. It focuses on the most relevant areas of application of these materials, viz. health, food, agriculture, and textiles.

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Investigation of moxifloxacin loaded chitosan-dextran nanoparticles for topical instillation into eye: In-vitro and ex-vivo evaluation

Cited by 41 publications

References 39 publications

Moxifloxacin and Sulfamethoxazole-Based Nanocarriers Exhibit Potent Antibacterial Activities

Moxifloxacin and Sulfamethoxazole-Based Nanocarriers Exhibit Potent Antibacterial Activities

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Antimicrobial Polymers in the Nano-World

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