Investigation of normal human saliva for possible anticarcinogenic action and chemical carcinogenesis in mucous membranes

Kolas, Steve

doi:10.1016/0030-4220(55)90383-2

Cited by 26 publications

(7 citation statements)

References 7 publications

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“…A major objeetion to the eheek pouch is that the truly intra-oral nature of this tissue is debatable. Kolas (1955) stated that the cheek poueh could not be considered to be representative of the oral cavity proper as it was not subjected to the same cnvitonmental influences as the rest of the mouth. However, the poueh appears to be equally suseeptible to careinogenesis over the whole of its surface, including the area adjaeent to the oral cavity proper, whieh is presumably subjected to the same environmental influences.…”

Section: ) Discussion Of the Cheek-pottch Modelmentioning

confidence: 99%

Animal models of infra‐oral chemical carcinogenesis: A review

Eveson

1981

J Oral Pathology Medicine

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Early attempts to induce malignant oral tumours were largely unsuccessful, us the oral mucosa is considerably more resistant to the actions of chemical carcinogens than skin. The first consistent success came when strong carcinogens were applied to the hamster cheek pouch. This model remains the most popular for studies of intra‐oral carcinogenesis and is discussed at length. The advantages and disadvantages are critically reviewed. The models of intra‐oral carcinogenesis in extra‐pouch sites in the hamster, mouse, rat and nonhuman primates arc considered. The possible reasons for the relative resistance of oral mucosa to chemical carcinogens are discussed, particularly in relation to portals of entry and saliva. Finally, the relative merits of the more popular models of intra‐oral carcinogenesis are briefly discussed.

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Section: ) Discussion Of the Cheek-pottch Modelmentioning

confidence: 99%

Animal models of infra‐oral chemical carcinogenesis: A review

Eveson

1981

J Oral Pathology Medicine

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“…Because of its peculiar anatomic site, environment and histology, some authors have questioned the suitability of the hamster cheek-pouch model for studies related to oral tumour induction. (Kolas 1955, Levy 1957, 1963, Stormby & Wallenius 1964. The use of another animal species would tend to avoid such potential bias and controversy.…”

mentioning

confidence: 99%

4 Nitroquinoline 1‐oxide‐induced carcinogenesis in the rat palate

Wong

Wilson

1983

J Oral Pathology Medicine

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Most reported studies of experimental oral cancer have been carried out in the hamster. This animal is not available in certain countries and there is controversy regarding its suitability as a model for experimental oral carcinogenesis. An attempt was made to reproduce an experimental oral cancer model in rats, using a protocol based on that described by Lekholm and Wallenius (1976). The carcinogen 4 nitroquinoline 1‐oxide was applied to the palates of rats for periods of up to 24 weeks. Macroscopic and microscopic examination of carcinogen‐treated palatal mucosa was carried out during the experimental period. Verrucous carcinoma‐like lesions of the mid‐palate and squamous carcinomas of the gingival mucosa were produced, beginning at 16 and 20 weeks respectively. A variety of other macroscopic and microscopic mucosal changes were also observed during the experimental period. The findings are discussed in relation to the work of others.

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“…This refractoriness has been attributed variously to putative protective effects of saliva and the result of a lack of adnexal structures in the oral mucosa such as hair follicles and sebaceous glands, which might provide "portals of entry" in skin. Kolas (60) was unable to demonstrate any protective effort of saliva, however, when it was applied to the ears of mice prior to treatment with 20-methyl-cholanthrene. Stomby and Wallenius (70), on the other hand, claimed to have demonstrated that reduced salivation increased both the incidence of cancer and the tendency towards malignant changes in palates painted with 9,10dimethyl-l,2-benzanthracene, although the effect was not statistically significant.…”

Section: Mechanisms Of Carcinogenesis 195mentioning

confidence: 91%

“…Analysis of the results of experimental chemical carcinogenesis in the oral cavity, has led to the assurnption that the oral cavity is more resistant to the effects of carcinogens than is skin (66)(67)(68)(69)60). This refractoriness has been attributed variously to putative protective effects of saliva and the result of a lack of adnexal structures in the oral mucosa such as hair follicles and sebaceous glands, which might provide "portals of entry" in skin.…”

Section: Mechanisms Of Carcinogenesis 195mentioning

confidence: 99%