Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics

Shin, Minsoo; Truong, Van-Long; Lee, Minjee; Kim, Dong-Gyu; Kim, Myun Soo; Cho, Hanna; Jung, Young Hoon; Yang, Jungwoo; Jeong, Woo-Sik; Kim, Young-Hoon

doi:10.1016/j.crfs.2022.100413

Cited by 13 publications

(10 citation statements)

References 46 publications

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“…PLA is also widely used in many other fields, such as medicine, feed, cosmetics, and gel materials, due to its non-toxicity to humans [ 11 , 12 ]. Recently, a study identified the microbial metabolite phenyllactic acid as a candidate inhibitor of tyrosinase and melanogenesis [ 13 ]. Although the antibacterial activity of PLA against several foodborne pathogenic bacteria has been well documented [ 14 ], as well as emerging reports on its anti-biofilm activity against Enterobacter cloacae [ 15 ], Pseudomonas aeruginosa [ 16 ], Listeria monocytogenes [ 17 ], and Enterococcus faecalis [ 18 ], to the best of our knowledge, the antifungal and antibiofilm activity of PLA against C. albicans has not yet been fully explored.…”

Section: Introductionmentioning

confidence: 99%

Anti-Biofilm Activity of Phenyllactic Acid against Clinical Isolates of Fluconazole-Resistant Candida albicans

Maione

Imparato

Buonanno

et al. 2023

JoF

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Commonly found colonizing the human microbiota, Candida albicans is a microorganism known for its ability to cause infections, mainly in the vulvovaginal region, and is responsible for 85% to 90% of vulvovaginal candidiasis (VVC) cases. The development of drug resistance in C. albicans isolates after long-term therapy with fluconazole is an important complication to solve and new therapeutic strategies are required to target this organism and its pathogenicity. In the present study, phenyllactic acid (PLA) an important broad-spectrum antimicrobial compound was investigated for its antifungal and antivirulence activities against clinical isolates of C. albicans. Previously characterized strains of C. albicans isolates from women with VVC and C. albicans ATCC90028 were used to evaluate the antimicrobial and time dependent killing assay activity of PLA showing a MIC 7.5 mg mL−1 and a complete reduction of viable Candida cells detected by killing kinetics after 4 h of treatment with PLA. Additionally, PLA significantly reduced the biomass and the metabolic activity of C. albicans biofilms and impaired biofilm formation also with changes in ERG11, ALS3, and HWP1 genes expression as detected by qPCR. PLA eradicated pre-formed biofilms as showed also with confocal laser scanning microscopy (CLSM) observations. Furthermore, the compound prolonged the survival rate of Galleria mellonella infected by C. albicans isolates. These results indicate that PLA is a promising candidate as novel and safe antifungal agents for the treatment of vulvovaginal candidiasis.

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Section: Introductionmentioning

confidence: 99%

Anti-Biofilm Activity of Phenyllactic Acid against Clinical Isolates of Fluconazole-Resistant Candida albicans

Maione

Imparato

Buonanno

et al. 2023

JoF

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“…WL is composed of BL and CFS, containing intracellular metabolites as well as the metabolites released into the medium. Phenyllactic acid, a common metabolite from the CFS of B. bifidum and L. plantarum by comparative metabolomics analyses, was identified as a tyrosinase inhibitor [ 34 ]. It is also worth identifying whether there are specific proteins from ZJ1 fermentation with the enzymatic activity to decolourise melanin [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Melanogenic and Antioxidant Activity of Bifidobacterium longum Strain ZJ1 Extracts, Isolated from a Chinese Centenarian

Wang

Zhang

et al. 2023

IJMS

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Melanin produced by melanocytes protects our skin against ultraviolet (UV) radiation-induced cell damage and oxidative stress. Melanin overproduction by hyperactivated melanocytes is the direct cause of skin hyperpigmentary disorders, such as freckles and melasma. Exploring natural whitening agents without the concern of toxicity has been highly desired. In this study, we focused on a Bifidobacterium longum strain, ZJ1, isolated from a Chinese centenarian, and we evaluated the anti-melanogenic activity of the distinctive extracts of ZJ1. Our results demonstrated that whole lysate (WL) and bacterial lysate (BL) of ZJ1 ferments efficiently reduce α-melanocyte-stimulating hormone (α-MSH)-induced melanin production in B16-F10 cells as well as the melanin content in zebrafish embryos. BL and WL downregulate melanogenesis-related gene expression and indirectly inhibit intracellular tyrosinase activity. Furthermore, they both showed antioxidant activity in a menadione-induced zebrafish embryo model. Our results suggest that ZJ1 fermentation lysates have application potential as therapeutic reagents for hyperpigmentary disorders and whitening agents for cosmetics.

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“…Thus, the application of probiotics in AP can restore the intestinal microbiota balance and prevent bacterial translocation and infection. In pancreatitis, the most commonly used probiotics are Lactobacillus acidophilus, Lactobacillus bulgaricus and Bifidobacterium bifidum [59][60][61]. Studies have shown that probiotics may shorten the length of hospital stay and reduce the infection rate in mild AP [62].…”

Section: Future and Prospectsmentioning

confidence: 99%

The Role of the Gut Microbiome in the Development of Acute Pancreatitis

Zhou,

Wu,

Yang

et al. 2024

IJMS

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With the explosion research on the gut microbiome in the recent years, much insight has been accumulated in comprehending the crosstalk between the gut microbiota community and host health. Acute pancreatitis (AP) is one of the gastrointestinal diseases associated with significant morbidity and subsequent mortality. Studies have elucidated that gut microbiota are engaged in the pathological process of AP. Herein, we summarize the major roles of the gut microbiome in the development of AP. We then portray the association between dysbiosis of the gut microbiota and the severity of AP. Finally, we illustrate the promises and challenges that arise when seeking to incorporate the microbiome in acute pancreatitis treatment.

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Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics

Cited by 13 publications

References 46 publications

Anti-Biofilm Activity of Phenyllactic Acid against Clinical Isolates of Fluconazole-Resistant Candida albicans

Anti-Biofilm Activity of Phenyllactic Acid against Clinical Isolates of Fluconazole-Resistant Candida albicans

Anti-Melanogenic and Antioxidant Activity of Bifidobacterium longum Strain ZJ1 Extracts, Isolated from a Chinese Centenarian

The Role of the Gut Microbiome in the Development of Acute Pancreatitis

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