Investigation of Physico-mechanical Behavior, Permeability and Wall Shear Stress of Porous HA/PMMA Composite Bone Scaffold

Mahammod, Babar Pasha; Barua, Emon; Deb, Payel; Deoghare, Ashish B.; Pandey, Krishna Murari

doi:10.1007/s13369-020-04467-w

Cited by 25 publications

(7 citation statements)

References 48 publications

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“…The solidification time was increased with the increase of MMA content, but the tensile strength of HA/PMMA composites reduced due to the addition of HA [195]. Mahammod et al [196]…”

Section: Hydroxyapatite (Ha)/polymethyl Methacrylate Nanocompositesmentioning

confidence: 99%

“…The solidification time was increased with the increase of MMA content, but the tensile strength of HA/PMMA composites reduced due to the addition of HA [195]. Mahammod et al [196] developed HA/PMMA using solvent casting particulate leaching technique; computational fluid dynamics (CFD) analysis concluded that HA/PMMA scaffold with 60 wt.% HA content tended to be the most promising choice for bone TE applications due to the best combination of porosity, permeability, and compressive strength [196]. The properties of HA/PMMA composites can be significantly improved using 3D printing in comparison with traditional techniques.…”

Section: Hydroxyapatite (Ha)/polymethyl Methacrylate Nanocompositesmentioning

confidence: 99%

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Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

Han

Wei

Chang³

et al. 2021

Crystals

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Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds. This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites. In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed. Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored. Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed.

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“…The solidification time was increased with the increase of MMA content, but the tensile strength of HA/PMMA composites reduced due to the addition of HA [195]. Mahammod et al [196]…”

Section: Hydroxyapatite (Ha)/polymethyl Methacrylate Nanocompositesmentioning

confidence: 99%

Section: Hydroxyapatite (Ha)/polymethyl Methacrylate Nanocompositesmentioning

confidence: 99%

Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

Han

Wei

Chang³

et al. 2021

Crystals

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“…There are many types of bone cement materials, including calcium sulfate (CSC), CPC, and polymethyl methacrylate (PMMA), each of which have undergone many basic research and clinical applications [ 149 , 150 ]. In addition, several bone cements with different characteristics have been mixed to prepare composite bone cements, such as PMMA and β-TCP [ 151 ], PMMA and HA [ 152 ], PMMA and CPC [ 153 ], etc. Currently, CPC and PMMA injectable bone cement have many clinical applications [ 154 ].…”

Section: The Composite Scaffolds For Repairing Bone Defectsmentioning

confidence: 99%

A 3D-Printed Scaffold for Repairing Bone Defects

Dong,

Ding,

Wang

et al. 2024

Polymers

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The treatment of bone defects has always posed challenges in the field of orthopedics. Scaffolds, as a vital component of bone tissue engineering, offer significant advantages in the research and treatment of clinical bone defects. This study aims to provide an overview of how 3D printing technology is applied in the production of bone repair scaffolds. Depending on the materials used, the 3D-printed scaffolds can be classified into two types: single-component scaffolds and composite scaffolds. We have conducted a comprehensive analysis of material composition, the characteristics of 3D printing, performance, advantages, disadvantages, and applications for each scaffold type. Furthermore, based on the current research status and progress, we offer suggestions for future research in this area. In conclusion, this review acts as a valuable reference for advancing the research in the field of bone repair scaffolds.

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“…Mahammod et al . [31] used a CFD analysis alongside mechanical compression tests to investigate the properties of different hydroxypatite–polymethylmethacrylate (HA/PMMA) composite scaffolds. The CFD analysis was conducted on geometries obtained through µCT of composite scaffolds fabricated with varying weight percentages of HA in a PMMA matrix (50–70%).…”

Section: Current Applications Of Cfd In Btementioning

confidence: 99%

Challenges in computational fluid dynamics applications for bone tissue engineering

et al. 2022

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Bone injuries or defects that require invasive surgical treatment are a serious clinical issue, particularly when it comes to treatment success and effectiveness. Accordingly, bone tissue engineering (BTE) has been researching the use of computational fluid dynamics (CFD) analysis tools to assist in designing optimal scaffolds that better promote bone growth and repair. This paper aims to offer a comprehensive review of recent studies that use CFD analysis in BTE. The mechanical and fluidic properties of a given scaffold are coupled to each other via the scaffold architecture, meaning an optimization of one may negatively affect the other. For example, designs that improve scaffold permeability normally result in a decreased average wall shear stress. Linked with these findings, it appears there are very few studies in this area that state a specific application for their scaffolds and those that do are focused on in vitro bioreactor environments. Finally, this review also demonstrates a scarcity of studies that combine CFD with optimization methods to improve scaffold design. This highlights an important direction of research for the development of the next generation of BTE scaffolds.

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Investigation of Physico-mechanical Behavior, Permeability and Wall Shear Stress of Porous HA/PMMA Composite Bone Scaffold

Cited by 25 publications

References 48 publications

Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

A 3D-Printed Scaffold for Repairing Bone Defects

Challenges in computational fluid dynamics applications for bone tissue engineering

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