Investigation of Polycaprolactone/Carboxymethyl Cellulose Scaffolds by Mechanical and Thermal Analysis

Abstract

The objective of this work was to learn more about three-dimensional porous scaffolds made from biomaterial based on polycaprolactone (PCL) containing different amounts of carboxymethyl cellulose (CMC) nanoparticles. Composite material samples containing 0, 2, 6.5, 11, 15.5, and 20% w/w of CMC and PCL/CMC scaffolds were prepared with the use of the salt particle leached technique. The mechanical properties were evaluated with the compressive strength analysis method. The studied temperature range started at very low temperatures and ended at crosslinking temperatures. It was evaluated using the thermal analysis methods of Differential Scanning Calorimetry (DSC) in the range 0ºC-200ºC. The results revealed that the compressive modulus of blended PCL/CMC scaffold was higher than the one of pure PCL scaffold (582.2±106.2 kPa for pure PCL scaffold and 612.2±296 kPa for blended scaffold which contained 20% of CMC). For DSC analysis, in addition to the 15.5% w/w CMC PCL/CMC composite scaffold, other proportions of composite materials showed a decrease in crystallization temperature. The crystallinity of PCL-20% CMC was higher than that of PCL scaffolds.

Effectiveness of a polycaprolactone scaffold combined with platelet-rich fibrin as guided tissue regeneration materials for preserving an implant-supported overdenture

“…Modern bone tissue engineering (BTE) is considered to be in its third generation, using more biocompatible osteoinductive, osteoconductive, and bony-like materials made from various cells, scaffolds, and growth factors, either alone or in combination ( Poomprakobsri et al, 2022 , Sousa et al, 2022b , Sriputtha et al, 2022 , Tawfik et al, 2022 ). PCL composite scaffolds are recognised for their significant role in tissue engineering for regenerating bone, ligament, cartilage, skin, nerve, and vascular tissues ( Ulery et al, 2011 , Zimmerling et al, 2021 ).…”

Evaluation of polycaprolactone/carboxymethylcellulose scaffolds using hyperelastic model

“…The PCL/CMC scaffolds tested were evaluated into six blends: 100/0, 98/2, 93.5/6.5, 89/11, 84.5/15.5, and 80/20. We cut the scaffold specimens into rectangular pieces 10 mm long, 10 mm wide, and approximately 3 mm thick [4]. The strain in the scaffolds ranged from 7% to 25%, as shown by the first compressive stress-strain curve used to calculate the compressive modulus and average standard deviation (n=5).…”

“…Damage or loss of tissue or body part is often one of the deadly and costly problems in medical care [2,3]. Tissue engineering (TE) has increased in significance because of the need to combine or apply multi-skilled methods for resolving this medical challenge [4]. The goal of TE is to replace or restore damaged tissue by employing artificial constructions that control the development of new tissue.…”