Investigation of porosity on mechanical properties, degradation and in-vitro cytotoxicity limit of Fe30Mn using space holder technique

Huang, Sabrina M.; Nauman, Eric A.; Stanciu, Lia

doi:10.1016/j.msec.2019.02.055

Cited by 37 publications

(23 citation statements)

References 46 publications

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“…For the electrochemical corrosion test, the corrosion potentials after coating shifted more positive for both non‐porous and porous Fe30Mn, as shown in Table , because the collagen coating acted as a protective layer that slowed down the anodic reactions for the alloy, which consequently reduced the metal dissolution releasing rate of electrons. We published data for the immersion test for non‐porous and porous Fe30Mn without coating in our previous paper . Since we are only looking at trends here, and the trends in the immersion test match those of the potentiodynamic polarization test, we presented the polarization test only here.…”

Section: Discussionmentioning

confidence: 99%

“…We published data for the immersion test for non-porous and porous Fe30Mn without coating in our previous paper. 15 Since we are only looking at trends here, and the trends in the immersion test match those of the potentiodynamic polarization test, we presented the polarization test only here. The electrochemical corrosion test also showed a reduction in CRs for both non-porous and porous collagen-coated samples comparing to samples without collagen coating (NP-C < NP-NC; 10P-NC < 10P-C) in Table 3.…”

Section: Discussionmentioning

confidence: 99%

“…Four experimental groups, non‐porous (NP‐NC), porous (10P‐NC), collagen‐coated non‐porous (NP‐C), and collagen‐coated porous (10P‐C) Fe30Mn samples were prepared by the methods described in “Sample Fabrication” and “Collagen Coating” sections. The potentiodynamic corrosion testing was conducted using the same method demonstrated in the previous study . In brief, every sample was mounted, cleaned with deionized (DI) water, and exposed to the electrolyte McCoy's 5A (ATCC, Manassas, VA) at 37 ± 2°C.…”

Section: Methodsmentioning

confidence: 99%

“…The potentiodynamic corrosion testing was conducted using the same method demonstrated in the previous study. 15 In brief, every sample was mounted, cleaned with deionized (DI) water, and exposed to the electrolyte McCoy's 5A (ATCC, Manassas, VA) at 37 ± 2°C. The current at the sample was recorded when the sample was applied to the potential scan from −0.15 V to +0.15 V at a rate of 0.1667 mV/ s. Using the Tafel curve, the corrosion potential and corrosion current were determined.…”

Section: Potentiodynamic Polarization Testmentioning

confidence: 99%

“…Besides enhancing degradation rates, porosity also helps to promote transport of oxygen and fluid nutrients, encouraging osteointegration and vascular invasion . In the authors' previous study, the effect of the degree of porosity on microstructure, mechanical properties, and corrosion behaviors of Fe30Mn alloy were investigated, and Fe30Mn alloys containing 10‐vol% porosity showed suitable mechanical and cytotoxicity compatibility characteristics for use into transient orthopedic fixation devices . However, the Fe‐30Mn alloy is inherently bioinert, which only provides non‐specific cell adhesion through van der Waals, ionic, and electrostatic forces .…”

mentioning

confidence: 99%

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Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Huang

Ulloa

Nauman

et al. 2019

Journal Orthopaedic Research

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Bioresorbable iron‐manganese alloys (Fe‐30%Mn) are considered as one of the next‐generation resorbable materials for orthopedic applications. Previous in vitro study showed that Fe30Mn scaffolds with 10% porosity displayed strong mechanical properties and adequate degradation rate without severe cytotoxicity effect. However, the cellular compatibility of these alloys in terms of cell‐to‐cell and alloy‐to‐cell interactions is not ideal. Collagen is the most abundant protein in human bone, providing structural support beneficial to bone healing. We hypothesized that coating collagen on Fe30Mn can improve osteointegration or activities promoting cell adhesion, migration, and proliferation, as the alloy degrades. After preparing collagen coating on Fe‐30Mn via spin coating, we conducted a corrosion test and a direct cytotoxicity test on four Fe30Mn groups: non‐porous and 10% porosity, with and without collagen coating. Furthermore, we evaluated and compared the morphologies of cells over a period of 7 days. Results showed that there was no significant difference between the collagen‐coated and non‐coated groups in corrosion rates, yet a significant decrease from the porous non‐coated group to the porous collagen‐coated group in cytotoxicity level was found. Cell morphology on the porous non‐coated group displayed round shape, whereas that on the porous collagen‐coated group displayed flattened spreading. The study showed that the collagen coating significantly increased the initial cell viability and adhesion for both the porous and non‐porous groups without impeding their degradation rates. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:523–535, 2020

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Potentiodynamic Polarization Testmentioning

confidence: 99%

mentioning

confidence: 99%

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Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Huang

Ulloa

Nauman

et al. 2019

Journal Orthopaedic Research

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Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Yusop

Ulum

Sakkaf

et al. 2021

Biotechnology Journal

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Iron (Fe) and Fe-based materials have been vigorously explored in orthopedic applications in the past decade mainly owing to their promising mechanical properties including high yield strength, elastic modulus and ductility. Nevertheless, their corrosion products and low corrosion kinetics are the major concerns that need to be improved further despite their appealing mechanical strengths. The current studies on porous Fe-based scaffolds show an improved corrosion rate but the in vitro biocompatibility is still problematic in general. Unlike the Mg implants, the biodegradation and bioabsorption of Fe-based implants are still not well described. This vague issue could implicate the development of Fe-based materials as potential medical implants as they have not reached the clinical trial stage yet. Thus, there is a need to understand in-depth the Fe corrosion behavior and its bioabsorption mechanism to facilitate the material design of Fe-based scaffolds and further improve its biocompatibility. This manuscript provides an important insight into the basic bioabsorption of the multi-ranged Fe-based corrosion products with a review of the latest progress on the corrosion & in vitro biocompatibility of porous Fe-based scaffolds together with the remaining challenges and the perspective on the future direction.

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Enhancing the degradation rate and biomineralization nature of antiferromagnetic Fe‐20Mn alloy by groove pressing

Sahu,

Sampath Kumar,

Chakkingal

et al. 2024

J Biomedical Materials Res

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The Fe‐Mn alloys are potential candidates for biodegradable implant applications. However, the very low degradation rates of Fe‐Mn alloys in the physiological environment are a major disadvantage. In this study, the degradation rate of a Fe‐20Mn alloy was improved using the groove pressing (GP) technique. Hot rolled sheets of 2 mm thickness were subjected to GP operation at 1000°C. Uniform fine‐grained (UFG) Fe‐Mn alloys were obtained using the GP technique. The influence of GP on the microstructure, mechanical properties, degradation behavior in simulated body fluid (SBF), surface wettability, biomineralization, and cytocompatibility was investigated and compared to the annealed (A Fe‐Mn) and rolled (R Fe‐Mn) sample. The groove‐pressed Fe‐Mn (G Fe‐Mn) alloy had a grain size of approximately 40 ± 16 μm whereas the A Fe‐Mn and R Fe‐Mn samples had grain sizes of 303 ± 81 and 117 ± 14.5 μm, respectively. Enhanced strength and elongation were also observed with the G Fe‐Mn sample. The potentiodynamic polarization test showed the highest Icorr, lowest polarization resistance, and lowest Ecorr for the G Fe‐Mn sample among all other samples indicating its higher degradation rate. The weight loss data from immersion tests also shows that the percentage of weight loss increases with time indicating the accelerated degradation behavior of the sample. The static immersion test showed an enhancement in weight loss of 0.46 ± 0.02% and 1.02 ± 0.05% for R Fe‐Mn and G Fe‐Mn samples, respectively, than A Fe‐Mn sample (0.31 ± 0.03%) after 56 days in immersion in SBF. The greater biomineralization tendency in UFG materials is confirmed by the G Fe‐Mn sample's stronger hydroxyapatite deposition. When compared to the A Fe‐Mn and R Fe‐Mn samples, the G Fe‐Mn sample has a better wettability, which promotes higher cell adhesion and vitality, showing higher biocompatibility. This study demonstrates that Fe‐20Mn processed by GP has potential applications for the manufacture of biodegradable metallic implants.

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Investigation of porosity on mechanical properties, degradation and in-vitro cytotoxicity limit of Fe30Mn using space holder technique

Cited by 37 publications

References 46 publications

Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Enhancing the degradation rate and biomineralization nature of antiferromagnetic Fe‐20Mn alloy by groove pressing

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