Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Huang, Sabrina M.; Ulloa, Ana; Nauman, Eric A.; Stanciu, Lia

doi:10.1002/jor.24492

Cited by 12 publications

(9 citation statements)

References 41 publications

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“…In an investigation by Huang et al, they checked the corrosion behaviour of collagen-coated porous and nonporous Fe-Mn [ 147 ]. In both porous and non-porous alloys, the collagen coating reduced the corrosion rate as the protein prevented direct contact of oxygen with the iron surface.…”

Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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Iron, while attracting less attention than magnesium and zinc, is still one of the best candidates for biodegradable metal stents thanks its biocompatibility, great elastic moduli and high strength. Due to the low corrosion rate, and thus slow biodegradation, iron stents have still not been put into use. While these problems have still not been fully resolved, many studies have been published that propose different approaches to the issues. This brief overview report summarises the latest developments in the field of biodegradable iron-based stents and presents some techniques that can accelerate their biocorrosion rate. Basic data related to iron metabolism and its biocompatibility, the mechanism of the corrosion process, as well as a critical look at the rate of degradation of iron-based systems obtained by several different methods are included. All this illustrates as the title says, what was done within the topic of biodegradable iron-based materials and what more can be done.

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Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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“…In several in vitro studies, FeMn-based alloys processed by conventional powder metallurgical routes or casting have been tested as a potential bone − as well as a cardiovascular implant material. Concerning cardiovascular application, cytotoxicity or viability of smooth muscle cells (SMCs), endothelial cells (ECs), or fibroblasts − on FeMn-based alloys was investigated by indirect culturing for up to 4 days.…”

Section: Introductionmentioning

confidence: 99%

Cell–Material Interactions in Direct Contact Culture of Endothelial Cells on Biodegradable Iron-Based Stents Fabricated by Laser Powder Bed Fusion and Impact of Ion Release

Paul

Lode

Placht

et al. 2021

ACS Appl. Mater. Interfaces

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Additive manufacturing is a promising technology for the fabrication of customized implants with complex geometry. The objective of this study was to investigate the initial cell−material interaction of degradable Fe-30Mn-1C-0.02S stent structures in comparison to conventional 316L as a reference, both processed by laser powder bed fusion. FeMn-based alloys have comparable mechanical properties with clinically applied AISI 316L for a corrosion-resistant stent material. Different corrosion stages of the as-built Fe-30Mn-1C-0.02S stent surfaces were simulated by pre-conditioning in DMEM under cell culture conditions for 2 h, 7 days, and 28 days. Human umbilical vein endothelial cells (HUVECs) were directly seeded onto the pre-conditioned samples, and cell viability, adherence, and morphology were analyzed. These studies were accompanied by measurements of iron and manganese ion release and Auger electron spectroscopy to evaluate the influence of corrosion products and degradation on the cells. In the initial phase (2 h of preconditioning), HUVECs were able to attach but the cell number decreased over the cultivation period of 14 days and the CD31 staining pattern of intercellular contacts was disordered. At later time points of corrosion (7 and 28 days of pre-conditioning), CD31 staining was distinctly located at the intercellular contacts, and the cell density increased after seeding and was stable for up to 14 days. Formation of a complex degradation layer, which had a composition and thickness dependent on the pre-conditioning time, led to a reduced ion release and finally showed a positive effect on cell survival. Concluding, our data suggest the suitability of Fe-30Mn-1C-0.02S for in vivo applications.

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“…Protein adsorption is known to be affected by various surface properties, such as roughness, organic impurities, chemical composition, van der Waals interactions, and hydrogen bonding [ 29 , 30 ]. Although many reports have described protein coating treatments of implant surfaces in the last decade, most titanium surface treatments require a period of several hours to several days [ 31 , 32 , 33 ]. However, in the present study, we performed UV pre-treatment and BMP-2 treatment for 1 min or UV pre-treatment and FN treatment for 1 h on the titanium surface for a short period of time using a simple method.…”

Section: Discussionmentioning

confidence: 99%

UV-Pre-Treated and Protein-Adsorbed Titanium Implants Exhibit Enhanced Osteoconductivity

Sugita

Saruta

Taniyama

et al. 2020

IJMS

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Titanium materials are essential treatment modalities in the medical field and serve as a tissue engineering scaffold and coating material for medical devices. Thus, there is a significant demand to improve the bioactivity of titanium for therapeutic and experimental purposes. We showed that ultraviolet light (UV)-pre-treatment changed the protein-adsorption ability and subsequent osteoconductivity of titanium. Fibronectin (FN) adsorption on UV-treated titanium was 20% and 30% greater after 1-min and 1-h incubation, respectively, than that of control titanium. After 3-h incubation, FN adsorption on UV-treated titanium remained 30% higher than that on the control. Osteoblasts were cultured on titanium disks after 1-h FN adsorption with or without UV-pre-treatment and on titanium disks without FN adsorption. The number of attached osteoblasts during the early stage of culture was 80% greater on UV-treated and FN-adsorbed (UV/FN) titanium than on FN-adsorbed (FN) titanium; osteoblasts attachment on UV/FN titanium was 2.6- and 2.1-fold greater than that on control- and UV-treated titanium, respectively. The alkaline phosphatase activity of osteoblasts on UV/FN titanium was increased 1.8-, 1.8-, and 2.4-fold compared with that on FN-adsorbed, UV-treated, and control titanium, respectively. The UV/FN implants exhibited 25% and 150% greater in vivo biomechanical strength of bone integration than the FN- and control implants, respectively. Bone morphogenetic protein-2 (BMP-2) adsorption on UV-treated titanium was 4.5-fold greater than that on control titanium after 1-min incubation, resulting in a 4-fold increase in osteoblast attachment. Thus, UV-pre-treatment of titanium accelerated its protein adsorptivity and osteoconductivity, providing a novel strategy for enhancing its bioactivity.

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Collagen Coating Effects on Fe–Mn Bioresorbable Alloys

Cited by 12 publications

References 41 publications

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Cell–Material Interactions in Direct Contact Culture of Endothelial Cells on Biodegradable Iron-Based Stents Fabricated by Laser Powder Bed Fusion and Impact of Ion Release

UV-Pre-Treated and Protein-Adsorbed Titanium Implants Exhibit Enhanced Osteoconductivity

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