Investigation of potential breath biomarkers for the early diagnosis of breast cancer using gas chromatography–mass spectrometry

Li, Jie; Peng, Yulan; Liu, Yong; Li, Wenwen; Jin, Ying; Tang, Zhentao; Duan, Yixiang

doi:10.1016/j.cca.2014.04.030

Cited by 110 publications

(92 citation statements)

References 43 publications

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“…The analysis of VOCs within exhaled breath provides a promising approach to the diagnosis of multiple tumor types. Phase 1 biomarker studies demonstrated the ability of breath VOC analysis for cancer diagnosis with a mean (SE) area under the ROC curve of 0.94 (0.01), a pooled sensitivity of 79% (95% CI, 77%-81%), and a pooled specificity of 89% (95% CI, 88%- Li et al, 15 90%). The noninvasive nature of breath testing offers an additional advantage that it enhances patient acceptability.…”

Section: Discussionmentioning

confidence: 99%

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

2019

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Section: Discussionmentioning

confidence: 99%

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

2019

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“…The content of the EBC can be analyzed, for example, using enzyme immunoassay kits or chromatography ‐ mass spectrometry techniques. The theory of EBA for cancer diagnosis is based on the concept that cancer initiation is associated with increase in oxidative stress that can cause alteration in the profile of deoxyribonucleic acid (DNA), proteins, and other components . Such alterations can be detected in exhaled breath as increased or decreased concentrations of biomarkers connected with a specific disease that is associated with specific pathologic changes .…”

Section: Exhaled Breath Analysismentioning

confidence: 99%

“…In many neoplasms, exhaled breath has been a rich source of potential cancers biomarkers . These biomarkers can be divided into three categories.…”

Section: Potential Breath Biomarkers Of Hncmentioning

confidence: 99%

Exhaled breath analysis in the diagnosis of head and neck cancer

et al. 2019

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Head and neck cancer (HNC) comprises a heterogeneous group of upper aerodigestive tract malignant neoplasms, the most frequent of which is squamous cell carcinoma. HNC forms the eighth most common cancer type and the incidence is increasing. However, survival has improved only moderately during the past decades. Currently, early diagnosis remains the mainstay for improving treatment outcomes in this patient population. Unfortunately, screening methods to allow early detection of HNC are not yet established. Therefore, many cases are still diagnosed at advanced stage, compromising outcomes. Exhaled breath analysis (EBA) is a diagnostic tool that has been recently introduced for many cancers. Breath analysis is non‐invasive, cost‐effective, time‐saving, and can potentially be applied for cancer screening. Here, we provide a summary of the accumulated evidence on the feasibility of EBA in the diagnosis of HNC.

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“…The diagnostic potential of exhaled breath metabolites in breast cancer have been demonstrated by some studies. These have resulted in the identification of significant diagnostic biomarkers such as 3-methylhexane, dec-1-ene, caryophyllene, naphthalene, trichloroethene [85], hexanal, heptanal, octanal and nonanal [86]. Metabolic profiling of exhaled breath has also been used for noninvasive diagnosis of liver cancer and has resulted in the identification of diagnostic biomarkers such as 3-Hydroxy-2-butanone, hepatocellular carcinoma and decane [89].…”

Section: Exhaled Breath As a Biomatrix For Noninvasive Metabolic Profmentioning

confidence: 99%

Noninvasive Metabolic Profiling for Painless Diagnosis of Human Diseases and Disorders

Mal¹

2016

Future Sci. OA

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Metabolic profiling provides a powerful diagnostic tool complementary to genomics and proteomics. The pain, discomfort and probable iatrogenic injury associated with invasive or minimally invasive diagnostic methods, render them unsuitable in terms of patient compliance and participation. Metabolic profiling of biomatrices like urine, breath, saliva, sweat and feces, which can be collected in a painless manner, could be used for noninvasive diagnosis. This review article covers the noninvasive metabolic profiling studies that have exhibited diagnostic potential for diseases and disorders. Their potential applications are evident in different forms of cancer, metabolic disorders, infectious diseases, neurodegenerative disorders, rheumatic diseases and pulmonary diseases. Large scale clinical validation of such diagnostic methods is necessary in future.

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Investigation of potential breath biomarkers for the early diagnosis of breast cancer using gas chromatography–mass spectrometry

Cited by 110 publications

References 43 publications

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis

Exhaled breath analysis in the diagnosis of head and neck cancer

Noninvasive Metabolic Profiling for Painless Diagnosis of Human Diseases and Disorders

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