Investigation of PPIX-Lipo-MnO2 to enhance photodynamic therapy by improving tumor hypoxia

Chudal, Lalit; Pandey, Nil Kanatha; Phan, Jonathan; Johnson, Omar; Li, Xiuying; Chen, Wei

doi:10.1016/j.msec.2019.109979

Cited by 57 publications

(38 citation statements)

References 40 publications

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“…In parallel, to enhance the efficiency of PDT or SDT, hypoxia-overcoming nanoformulations have been designed [ 16 , 41 , 42 , 43 , 44 , 45 ]. Recent approaches include oxygenation by a hydrogen peroxide (H 2 O 2 ) catalysis [ 46 , 47 ] and oxygen delivery using hemoglobin [ 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

et al. 2020

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Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

et al. 2020

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“…In PPIX‐Lipo‐M, the in situ production of oxygen from endogenous H 2 O 2 was catalyzed by MnO 2 to relieve hypoxia (Figure 12D ). [ 149 ] With good biocompatibility and high catalytic capacity, liposomal catalase also catalyzed the transformation of H 2 O 2 to O 2 to alleviate tumor hypoxia, which was validated to enhance not only PDT, but also antitumor immunity by reversing the immunosuppressive TME. [ 150 ] The contribution of the latter to enhance PDT has often been neglected in most studies on hypoxia‐relief strategies.…”

Section: Biomedical Applications Of Liposomal System In Tumor Theranosticmentioning

confidence: 99%

Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

et al. 2021

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Although photodynamic therapy (PDT) has promising advantages in almost non‐invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half‐life of PS in plasma, poor tissue penetration, and low tumor specificity. To overcome these limitations and enhance PDT, liposomes, as excellent multi‐functional nano‐carriers for drug delivery, have been extensively studied in multi‐functional theranostics, including liposomal PS, targeted drug delivery, controllable drug release, image‐guided therapy, and combined therapy. This review provides researchers with a useful reference in liposome‐based drug delivery.

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“…Photodynamic therapy (PDT), a promising cancer treatment modality with minimal invasiveness, negligible drug resistance and low side effects, employs a photosensitizer (PS) that can be excited by light of suitable wavelength to form ROS, which can induce apoptosis and/or necrosis in treated cells. Also, PDT can be used either on its own or in combination with other therapeutic modalities, such as surgery, chemotherapy, radiotherapy, or immunotherapy [ [1] , [2] , [3] ]. Even though PDT has great potential for clinical use, conventional PSs generally suffer from aggregation-caused fluorescence quenching and a significant reduction in ROS production in aqueous media [ [4] , [5] , [6] , [7] ].…”

Section: Introductionmentioning

confidence: 99%

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

Pandey

Wang

et al. 2022

Bioactive Materials

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Aggregation-induced emission luminogens (AIEgens) exhibit efficient cytotoxic reactive oxygen species (ROS) generation capability and unique light-up features in the aggregated state, which have been well explored in image-guided photodynamic therapy (PDT). However, the limited penetration depth of light in tissue severely hinders AIEgens as a candidate for primary or adjunctive therapy for clinical applications. Coincidentally, microwaves (MWs) show a distinct advantage for deeper penetration depth in tissues than light. Herein, for the first time, we report AIEgen-mediated microwave dynamic therapy (MWDT) for cancer treatment. We found that two AIEgens ( TPEPy-I and TPEPy-PF6 ) served as a new type of microwave (MW) sensitizers to produce ROS, including singlet oxygen ( 1 O 2 ), resulting in efficient destructions of cancer cells. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and live/dead assays reveal that the two AIEgens when activated by MW irradiation can effectively kill cancer cells with average IC-50 values of 2.73 and 3.22 μM, respectively. Overall, the ability of the two AIEgens to be activated by MW not only overcomes the limitations of conventional PDT, but also helps to improve existing MW ablation therapy by reducing the MW dose required to achieve the same therapeutic outcome, thus reducing the occurrence of side-effects of MW radiation.

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Investigation of PPIX-Lipo-MnO2 to enhance photodynamic therapy by improving tumor hypoxia

Cited by 57 publications

References 40 publications

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy

Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

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