Investigation of primary nucleation phenomena of acetylsalicylic acid crystals induced by ultrasonic irradiation—ultrasonic energy needed to activate primary nucleation

Effect of High Intensity Ultrasound on Crystallization Behavior of Anhydrous Milk Fat

“…A substantial amount of information regarding the use of sonocrystallization can be found in the literature. Pharmaceutical [8][9][10][11][12], chemical [13][14][15][16][17][18][19][20][21] and food applications [22,23] are the most common. Specifically for food science applications, Dr. Povey's group has extensively studied the effect of HIU in sucrose solutions.…”

Polymorph control of sulfamerazine by ultrasonic irradiation

“…Moreover, sonication initiates primary nucleation, decreases metastable zone width, shortens induction time, and increases nucleation rate [10][11][12][13][14][15][16][17]. Sonication can therefore be used to induce nucleation in systems where such a process is difficult to achieve, as well as to produce a more uniform particle size distribution and a smaller mean particle size [18].…”

Effect of ultrasonic irradiation on the behavior of primary nucleation of amino acids in supersaturated solutions

“…In our previous study [21,22], we reported that the average number of crystals decreased at low ultrasonic energies and increased at high energies in static supersaturated solutions of aspirin. Therefore, the results in this study indicate that the number of nuclei overcoming the free energy barrier DG crit at the primary nucleation stage is smaller at low ultrasonic energies under the inhibitory influence of ultrasonication.…”

“…In the other, specific amount of ultrasonic energy increase the number of primary nuclei. From these results, Miyasaka et al [22] suggested the possibility that the crystal size of a final product could be controlled by controlling the number of primary nucleation sites with an appropriate amount of ultrasonic energy.…”