Polymorph control of sulfamerazine by ultrasonic irradiation

Kurotani, Masahiro; Hirasawa, Izumi

doi:10.1016/j.jcrysgro.2008.08.002

Cited by 39 publications

(28 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FIII was discovered only recently in 2006 . Solvent‐mediated transformations of SMZ polymorphs in solution have been extensively studied . The effect of compression and milling on powder samples has also been reported .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Ball-Milling and Cryomilling on Sulfamerazine Polymorphs: A Quantitative Study

MacFhionnghaile

Gniado

et al. 2014

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

The effects of ball-milling and cryomilling on sulfamerazine forms I and II (SMZ FI, FII) were investigated using X-ray powder diffraction, IR and NIR spectroscopy. Cryomilling resulted in the complete amorphization of both polymorphs. Milling at room temperature gave mixtures of amorphous SMZ (FA) and FII. Calibration models were developed for the quantitative analysis of binary (FI/FII, FI/FA and FII/FA) and ternary (FI/FII/FA) mixtures using NIR spectroscopy combined with partial least-squares (PLS) regression. The PLS models for binary (0 -100 %), ternary (0 -100 %) and low level (0 -10 %) binary mixtures had root-mean-square errors of prediction of 1.8, 5.1 and 0.80 %, respectively. The calibration models were used to obtain a detailed quantitative picture of solid-state transformations during milling and any subsequent recrystallizations. FA prepared by cryomilling FI for less than 60 min. recrystallized to mixtures of FI and FII, while samples milled for more than 60 min. crystallized to pure FII. The effect of co-milling SMZ with stoichiometric amounts of additives was investigated. SMZ formed amorphous materials with oxalic, DL-tartaric and citric acids that were more stable towards recrystallization than FA.Amorphous SMZ/oxalic acid was found to recrystallize to a 2:1 co-crystal during storage.

show abstract

Section: Introductionmentioning

confidence: 99%

“…29 Solvent-mediated transformations of SMZ polymorphs in solution have been extensively studied. [32][33][34][35][36][37][38] The effect of compression and milling on powder samples has also been reported. 30,[39][40][41] Chattoraj et al 39 observed partial amorphization of FI during cryomilling.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ball-Milling and Cryomilling on Sulfamerazine Polymorphs: A Quantitative Study

MacFhionnghaile

Gniado

et al. 2014

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

“…In recent years, the use of external stimuli to induce polymorph formation has attracted much attention. External stimuli, including polarized near-infrared laser light [17], ultrasonic irradiation [18] and patterned self-assembled monolayer (SAM) substrates [19,20], usually enhance the nucleation process of certain polymorphic form thereby biasing its production. Besides the aforementioned factors, the rate of supersaturation generation has been shown to play a significant role in determining the polymorphic outcome [5,[21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Effects of the rate of supersaturation generation on polymorphic crystallization of m-hydroxybenzoic acid and o-aminobenzoic acid

Wong

Tan

2011

Journal of Crystal Growth

View full text Add to dashboard Cite

“…Transforming metastable crystals of sulfamerazine into stable crystals normally takes over two weeks (Gu et al, 2001). When applying ultrasonication, the phase transformation of sulfamerazine including polymorphic nucleation was shortened to 100 h (Kurotani and Hirasawa, 2008). However, when using a Taylor vortex, the phase transformation including polymorphic nucleation was accomplished within 7 h, even with a moderate intensity Taylor vortex (Figure 4).…”

Section: Phase Transformation With Taylor Vortexmentioning

confidence: 99%

Application of Taylor Vortex to Crystallization

Kim

2014

J. Chem. Eng. Japan / JCEJ

View full text Add to dashboard Cite

This study summarizes crystallization technology when using a Taylor vortex ow. A Taylor vortex is created in the gap between two co-axially positioned cylinders based on the rotation of the inner cylinder. Due to its unique periodic ow motion, a Taylor vortex has a signi cant in uence on the processes of nucleation, growth, and agglomeration breakage in various crystallizations, including reaction recrystallization, drowning-out crystallization, and cooling crystallization. In the gas-liquid reaction crystallization of calcium carbonate, the mass transfer at the gas-liquid interface is greatly facilitated by a Taylor vortex, resulting in small crystals with a uniform size and morphology. Further, due to molecular alignment by the periodic Taylor vortex motion, the polymorphic nucleation of stable crystals is also promoted. This e ect of molecular alignment by a Taylor vortex is demonstrated by the phase transformation of sulfamerazine. Furthermore, the Taylor vortex ow in a Taylor crystallizer improves the productivity of crystallization when compared with the random turbulent eddy ow in an MSMPR crystallizer. Consequently, the high performance of a Taylor crystallizer using a Taylor vortex has strong potential for application to various crystallizations.

show abstract

Polymorph control of sulfamerazine by ultrasonic irradiation

Cited by 39 publications

References 20 publications

Effects of Ball-Milling and Cryomilling on Sulfamerazine Polymorphs: A Quantitative Study

Effects of Ball-Milling and Cryomilling on Sulfamerazine Polymorphs: A Quantitative Study

Effects of the rate of supersaturation generation on polymorphic crystallization of m-hydroxybenzoic acid and o-aminobenzoic acid

Application of Taylor Vortex to Crystallization

Contact Info

Product

Resources

About