Investigation of prolonged neonatal jaundice

Abstract

In conclusion, a large number of infants referred to hospital for prolonged jaundice screening had detectable problems. The number of investigations may safely be reduced to: a total and conjugated bilirubin, packed cell volume, glucose-6-phosphate dehydrogenase level (where appropriate), a urine for culture and inspection of a recent stool sample for bile pigmentation. Clinical examination by a paediatrician has a vital role in the screening process.

Different causes of prolonged unconjugated Jaundice in the newborns

“…Breast milk jaundice 66% (66), Rh-isoimmunization 10% (10), hypothyroidism 7% (7), extravasated blood (cephalhematoma) 7% (7), UTI 4% (4), ABO incompatibility 3% (3), G6PD deficiency 1% (1), hemorrhage/bruising 2% (2). N. Najati, M.M.…”

“…According to the literature, breastfeeding is a major cause of prolonged jaundice, and about 40% of infants who are exclusively breastfed are diagnosed with this disorder. [2][3][4][5] Among other pathological causes associated with prolonged hyperbilirubinemia are urinary tract infection (UTI), congenital hypothyroidism and hemolysis. Therefore, these factors should be taken into account in the evaluation of neonates for jaundice.…”

Lotus Birth Associated With Idiopathic Neonatal Hepatitis

“…Jaundice persisting beyond 14 days of life is less frequent and usually, further causes of jaundice must be excluded. 3,4 In the present case, the infant presented with a complication of LB. There was a close temporal relationship between LB and the onset of clinical symptoms.…”

Infection and Incidence of Herpes Viruses in Neonates in Aktobe Region of Kazakhstan

“…A survey of a patient without the use of relevant protocols and methodological requirements leads to the fact that the doctors of practical public health, in the case of favorable clinical outcome discharge patients with a diagnosis of "neonatal or conjugational jaundice", do not take into account the presence of CMV IgG antibodies. However, recognizing that CMV is a hepatotropic agent, traditionally it is believed that this virus primarily affects the bile ducts with the development of cholestatic hepatitis and a congenital abnormality of the bile duct [29,30]. A severe liver damage with the development of cholestatic jaundice and the formation of fibrosis of the liver occurs with a frequency of 1:2,500 to 1:10,000 births [31].…”