Investigation of receptors mediating serotonin stimulation of mouse liver regeneration

The function of serotonin within the liver

“…They observed a mobilisation of intestinal serotonin and accumulation in the liver and spleen following PHx [39]. Subsequent work showed enhanced hepatocyte proliferation following low-dose administration of serotonin also to mice subjected to PHx [38]. The role of serotonin agonists, 5-methoxytryptamine and a-naphthylbiguanide (a 5-HT 3 receptor agonist) and that of the antagonist Lisuride on regeneration following PHx were also investigated.…”

“…5-HT, 5-hydroxytryptamine; CTGF, connective tissue growth factor; GDP, guanosine diphosphate; GTP, guanosine triphosphate: HSC, hepatic stellate cell; SERT, serotonin transporter. Table 2 Outline of the cell-specific expression of various components of the 5-HT dependent signalling pathways and those functions regulated PHx [37][38][39]. They observed a mobilisation of intestinal serotonin and accumulation in the liver and spleen following PHx [39].…”

525 Effect of 5-Ht7 Receptor Blockade on Liver Regeneration After Partial Hepatectomy

“…Reports regarding implication of serotonin in liver regeneration are dated back in the early 80s in non-English literature or even earlier [5,6]. A number of recent in vivo studies including studies from our laboratory have elucidated the role of serotonin in liver regeneration after partial hepatectomy [7][8][9] with platelets to be the major reservoir accounting for the increased hepatic concentrations of the monoamine during liver regeneration.…”

The importance of platelet-derived serotonin in mediating hepatic regeneration

“…In a recent article published in Science by Pierre-Alain Clavien and colleagues from Zurich, serotonin derived from platelets was also shown to govern liver regeneration [3]. Although scantly mentioned over 20 years ago in the Russian radiobiology literature [4,5], almost nothing was known about the beneficial role of serotonin in hepatic regeneration until now.Using a model of partial hepatectomy, mice rendered thrombocytopenic, or those with pharmacologically impaired platelet activity, showed decreased regenerative capacity in the liver [3]. A serotonin agonist restored the deficient hepatic proliferation in the platelet-depleted mice.…”

“…In a recent article published in Science by Pierre-Alain Clavien and colleagues from Zurich, serotonin derived from platelets was also shown to govern liver regeneration [3]. Although scantly mentioned over 20 years ago in the Russian radiobiology literature [4,5], almost nothing was known about the beneficial role of serotonin in hepatic regeneration until now.…”