Investigation of retention behavior of drug molecules in supercritical fluid chromatography using linear solvation energy relationships

Supercritical Fluid Chromatography of Drugs: Parallel Factor Analysis for Column Testing in a Wide Range of Operational Conditions

“…A set of 14 drugs including different pharmaceutical families and covering a wide range of p K a and log  P [38] was chosen to test and classify the 8 selected stationary phases. Scheme 1 provides the full structures of the drugs with their known physicochemical properties.…”

Advances in High Throughput Supercritical Fluid Chromatography

“…[8,57,72,73] Additional columns that could be utilized, depending on the specific application, include silica, testosterone, and porous graphite carbon phases. [66,67,74,75] If mass spectrometric detection is not used, the addition of acidic or basic counter ions will dramatically improve peak shapes and decrease retention from polar stationary phases. SFC has also been successfully used with ion pair reagents.…”

“…[71,72,77,78] If retention is not achieved using polar columns, switching to non-polar columns can be warranted. West et al have published detailed works on the use of alkyl phases for exquisite separations of steroids, non-steroidal anti-inflammatory drugs (NSAIDs), xanthines, purines, pyrimidines, sulfonamides [1,49,67,72] sunscreens, [70] alkylbenzenes, [1,65,66] carotenoids, [1] triglycerides, [1] lipids, ceramides, phospholipids, and glycolipids, [67,72,79] that could potentially be optimized for HT applications.…”

“…[2,3,8,65,66] Mass spectrometry (MS) detection is typically used for HT operations, along with columns packed with polar, basic ligands such as 2-ethylpyridine or morpholine, which are usually employed. These stationary phases provide diverse separations, compatibility with acidic=basic solutes, and can be used without counter ions that could diminish ionization.…”

Separation of Inorganic Anions on a Pyridine Stationary Phase in Ion Chromatography

“…4 The retention behaviors of substituted benzenes and different drug compounds were investigated on a 2-ethylpyridine bonded silica column in supercritical fluid chromatography. 5 Tertiary pyridine resin was also used for the separation of strontium from other alkaline earth elements and alkali metal elements using a methanol/nitric acid mixed solution. 6 2-Vinylpyridine and 4-vinylpyridine were used as a functional monomer to prepare uniformly sized molecularly imprinted polymers for chiral recognition of nilvadipine and other dihydropyridine calcium antagonists using a mixture of sodium phosphate buffer (or water) and acetonitrile or only acetonitrile as the mobile phase.…”