Investigation of SNPs in FABP3 and FABP4 Genes and Their Possible Relationships with Fatty Acid Composition in Broiler

Maharani, Dyah; Park, Hee Bok; Jung, Y. C.; Jung, Samooel; Jo, Cheorun; Lee, Jun–Heon

doi:10.5536/kjps.2011.38.3.231

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…The occurrence of the T allele lowered the DHA value, which is essential in nutritional products, especially recommended for children, as it is associated with improvement in brain growth and function [ 38 ]. A similar result of DHA decrease in the meat of TT genotype broilers was reported by Maharani et al [ 29 ]. In the present study, no effect of the g.285 C>T substitution on the content of arachidonic acid C20:4 was found, as demonstrated by other authors [ 29 ].…”

Section: Discussionsupporting

confidence: 87%

“…A similar result of DHA decrease in the meat of TT genotype broilers was reported by Maharani et al [ 29 ]. In the present study, no effect of the g.285 C>T substitution on the content of arachidonic acid C20:4 was found, as demonstrated by other authors [ 29 ]. There was a tendency of higher MUFA, PUFA and hypocholesterolemic DFA acid contents in birds with the g.285 C>T substitution, but these differences were not statistically significant.…”

Section: Discussionsupporting

confidence: 87%

“…The wild-type C allele occurred with the highest frequency (0.55). A similar distribution of genotypes was demonstrated in Ross broilers in the study of Maharani et al (2011) [ 29 ], but it should be noted that genotype distribution could depend on breed or lineage, as the TT genotype was most frequent in Korean chickens [ 30 ].…”

Section: Discussionsupporting

confidence: 65%

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The g.4290 C>G Polymorphism in the FADS2 Gene Modifies the Fatty Acid Profile of the Pectoralis Superficialis Muscle of Ross 308 Broiler Chickens

Kaczor

Sawicki

Nowak

et al. 2022

Animals

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The effect of the g.4290 C>G substitution in the FADS2 gene and g.285 C>T in the FABP4 gene on carcass quality, meat quality, and fatty acid profile of the pectoralis superficialis muscle of 238 male broiler chickens reared up to 45 days of age was analyzed. A significant influence of g.4290 C>G in the FADS2 gene on the pectoralis superficialis muscle fatty acid profile was demonstrated. Chickens with the GG genotype were characterized by the highest content of conjugated linoleic acid, amino acids, eicosapentaenoic acids, docosapentaenoic acid, docosahexaenoic acids. and the lowest value of the linoleic acid/alpha-linolenic acid ratio. The FABP4 polymorphism determined only the content of C18:1n-9, C18:2n-6 and docosahexaenoic acid. There was no effect of the studied genotypes on final body weight, carcass quality traits, or quality of broiler pectoral muscles.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

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The g.4290 C>G Polymorphism in the FADS2 Gene Modifies the Fatty Acid Profile of the Pectoralis Superficialis Muscle of Ross 308 Broiler Chickens

Kaczor

Sawicki

Nowak

et al. 2022

Animals

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“…Two pairs of primers, one for FABP3 gene and another for FABP4 gene, were designed based on Maharani et al (2011).…”

Section: Pcr Condition and Genotypingmentioning

confidence: 99%

FABP3 and FABP4 Genes Are the Potential Candidates for Body Weights in Korean Native Chicken

Cahyadi¹,

Seo²,

Choi³

et al. 2013

Korean Journal of Poultry Science

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FABPs, 15 kDa organic substances, are small intracellular proteins which have a primary role to regulate fatty acid uptake and intracellular transport. This study was conducted to identify SNPs in the two FABP family genes and their associations with the body weight traits in Korean native chicken (KNC). Two SNPs, namely g.508C>T of FABP3 gene and g.285C>T of FABP4 gene, have been genotyped by using PCR-RFLP method. The results showed that FABP3 was significantly associated with body weight at birth, body weights at 12 to 20 weeks, and also slaughter weight. Moreover, the g.285C>T SNP of FABP4 gene was not associated with any body weight traits. These results suggested that the g.508C>T SNP of FABP3 genes can be used as molecular markers to select KNC having desirable body weights.

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“…Compared with studies of beef and pork, relatively few chicken meat studies have examined the genetic relationships of candidate genes with the fatty acid composition. Maharani et al (2011; Smet et al, 2004). Fat deposition is a major factor that affects the fatty acid composition of pig and ruminant meats (Wood et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Epistatic Effects of Six Candidate Genes on Fatty Acid Composition in Korean Native Chicken

Jin¹,

Lee²,

Lee³

et al. 2021

Korean J. Poult. Sci.

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Fatty acid composition is an important economic trait that affects meat flavor. Several genes that influence fatty acid composition in meat have been investigated. In a previous study, we identified 51 significant SNP × SNP interactions (P≤0.05) between nine SNPs of six candidate genes (DEGS1, ELOVL6, FABP3, FABP4, FASN, and SCD) on meat fatty acid composition in Korean native chicken. This study further investigated the patterns of the SNP × SNP interactions to understand how they affect the fatty acid content in thigh and breast meat of Korean native chicken. The significant epistatic effects of SNP combinations showed various patterns for each fatty acid trait. The results of this study suggest that the respective additive effects of each SNP on polygenic traits, such as fatty acid composition, should be considered in combination with the epistatic effect of SNP combinations in animal breeding programs. The findings of this study have provided new genetic information for improving meat quality, especially the fatty acid composition, of Korean native chicken.

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Investigation of SNPs in FABP3 and FABP4 Genes and Their Possible Relationships with Fatty Acid Composition in Broiler

Cited by 4 publications

References 17 publications

The g.4290 C>G Polymorphism in the FADS2 Gene Modifies the Fatty Acid Profile of the Pectoralis Superficialis Muscle of Ross 308 Broiler Chickens

The g.4290 C>G Polymorphism in the FADS2 Gene Modifies the Fatty Acid Profile of the Pectoralis Superficialis Muscle of Ross 308 Broiler Chickens

FABP3 and FABP4 Genes Are the Potential Candidates for Body Weights in Korean Native Chicken

Epistatic Effects of Six Candidate Genes on Fatty Acid Composition in Korean Native Chicken

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