Investigation of some blood biochemical parameters in sheep naturally infected with theileriosis

Baghishani, Hasan; Gholam, R.; Yaghfoori, Saeed; Ahmadi, Amin

doi:10.1016/j.clinbiochem.2011.08.330

Cited by 5 publications

(8 citation statements)

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“…In goats with babesiosis, CAT activity significantly decreased with increased parasitemia (Esmaeilnejad et al 2014). However, contrary to our results, Baghishani et al (2011) reported increased CAT activity and decreased SOD activity in sheep naturally infected with Theileria. ROS homeostasis depends on balanced activity of antioxidant enzymes (Nikolić-Kokić et al, 2010) and this balance results from interdependent changes in the intracellular activity of antioxidant enzymes.…”

Section: Discussioncontrasting

confidence: 99%

“…ROS homeostasis depends on balanced activity of antioxidant enzymes (Nikolić-Kokić et al, 2010) and this balance results from interdependent changes in the intracellular activity of antioxidant enzymes. It is possible that increased CAT activity detected by Baghishani et al (2011) could have resulted from decreased activity of SOD and consequent decreased production of H 2 O 2 .…”

Section: Discussionmentioning

confidence: 99%

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Oxidative stress and DNA damage in horses naturally infected with Theileria equi

Radaković

Davitkov

Borozan

et al. 2016

The Veterinary Journal

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The aim of this study was to determine the concentrations of oxidative stress parameters and DNA damage in horses infected by Theileria equi. Initial screening of 110 horses with duplex PCR enabled the selection of 30 infected horses with T. equi and 30 free of infection (control). Specimens from the 60 horses were further analysed by determining the following oxidative stress parameters: extent of haemolysis (EH), plasma free haemoglobin (PHb), catalase (CAT), Cu,Zn superoxide dismutase (SOD1), paraoxonase (PON1), nitrite (NO), total nitrate and nitrite (NOx), malondialdehyde (MDA) and free thiol groups (-SH). In addition, relative distribution of lactate dehydrogenase (LDH-LDH) activity and the DNA-damaging effects of T. equi infection were evaluated. Compared to control horses, horses infected with T. equi had significantly higher SOD1 activities (P <0.05) and PHb (P <0.01), NO (P <0.001), NOx (P <0.05) and MDA concentrations (P <0.001), and significantly lower EH (P <0.001), CAT (P <0.01) and PON1 (P <0.001) activities, and thiol group concentrations (P <0.05). The comet assay demonstrated significantly increased DNA damage in T. equi infected cells compared to non-infected cells (P <0.001). Infected horses had significantly increased LDH isoenzyme activities (P <0.05). There was higher production of ROS/RNS in T. equi-infected horses, which resulted in changes in osmotic fragility, damage to lipids, proteins and DNA, haemolysis and hepatocellular damage. Oxidative stress in horses naturally infected with T. equi could contribute to the pathogenesis of the infection.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oxidative stress and DNA damage in horses naturally infected with Theileria equi

Radaković

Davitkov

Borozan

et al. 2016

The Veterinary Journal

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“…In contrary to SOD and GPx pattern, Catalase showed non-significant increase in diseased calves. Similar results were found in T. annulate infected cows and Thelieria -infected sheep [42] , [43] . Catalase is accountable for H 2 O 2 removal and thus it provides protection against damaging effect of H 2 O 2 leading to rise RBCs lifetime, so the increase in its activity may be contributed to the indirect compensatory reaction to oxidant encounter [43] .…”

Section: Discussionsupporting

confidence: 87%

Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves

Salem

Yehia

Farag

et al. 2016

International Journal of Veterinary Science and Medicine

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Babesia is one of the main causes of anemia in cattle, a lot of elucidations have been suggested to explain its pathogenesis. This study was designed to investigate clinical, hemato-biochemical and oxidant/antioxidant status and its relation with the resultant anemia in Babesia-infected calves. Seventeen (17) native breed calves were involved in this study, clinical signs and microscopic findings were recorded, also blood samples were taken to investigate hematologic changes, serum biochemical variations and oxidative stress biomarkers. The most commonly observed clinical signs were fever, emaciation, depression, icterus and hemoglobinuria. Significant reduction in PCV, HB, RBCs, MCHC, Total protein, and albumin along with significant increase in MCV, WBCs, monocytes and BUN were the most consistent hemato-biochemical changes. Oxidant/antioxidant and trace mineral assessment showed significant reduction in Superoxide dismutase “SOD”, Glutathione peroxidase “GPx”, Zn, Cu along with significant increase in malondialdehyde (MDA) activities. In the current investigation, oxidant/antioxidant imbalance along with the synchronized alterations in antioxidant trace minerals was detected in Babesia-infected calves. These findings support notion that Babesia infection associated with oxidative stress and this process may be linked to the resultant anemia.

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“…MDA is the last product of lipid peroxidation, and is a key marker of oxidative stress ( 9 ). Various studies have reported that lipid peroxidation products, such as MDA, increase in diseases such as theileriosis in sheep ( 4 ) and coccidiosis ( 37 ) and transportation ( 2 ) in cattle. There are also other studies related to the evaluation of oxidative stress in ruminant skin diseases.…”

Section: Resultsmentioning

confidence: 99%

“…The determination of oxidative stress has become important recently in clinical practice as a complementary component ( 8 ). The occurrence of oxidative stress is proven under various conditions such as sepsis, mastitis, enteritis, respiratory and joint disease, endoparasitic diseases, transportation, and pregnancy in ruminants, and oxidative stress should be considered for the prognosis and effective treatment procedure of these conditions ( 2 , 4 , 18 , 21 , 26 , 30 ). There are limited studies which evaluate oxidative stress in sheep mange ( 13 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative stress in sheep infected with Psoroptes ovis using total antioxidant capacity, total oxidant status, and malondialdehyde level

Aktaş

Kandemir

Kirbaş

et al. 2017

Journal of Veterinary Research

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IntroductionThe study aimed at evaluating oxidative stress using malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) markers in sheep naturally infected with Psoroptes ovis(Acari).Material and MethodsThe study was performed on 40 sheep divided into two equal groups: a healthy group (group I) and a group naturally infected with Psoroptes ovis (group II). The sera were obtained by centrifuging blood samples collected from the vena jugularis and serum MDA level changes in the samples were measured spectrophotometrically. Commercially available test kits were used for the measurement of TAC and TOS levels. The percentage ratio of TOS level to TAC level was accepted as OSI.ResultsThe serum malondialdehyde, total oxidant status levels, and oxidative stress index increased significantly (P < 0.01) in group II, while the serum total antioxidant capacity levels decreased significantly (P < 0.01) in this group. Negative correlations between total antioxidant capacity and total oxidant status and total antioxidant capacity and malondialdehyde, and a positive correlation between total oxidant status and malondialdehyde were found in infected sheep.ConclusionThe obtained results indicated the relationship between oxidant/antioxidant imbalance and Psoroptes ovis infection in sheep. Their MDA, TAC, TOS, and OSI markers may be used to determine the oxidative stress in natural infections with Psoroptes ovis.

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Investigation of some blood biochemical parameters in sheep naturally infected with theileriosis

Cited by 5 publications

References 0 publications

Oxidative stress and DNA damage in horses naturally infected with Theileria equi

Oxidative stress and DNA damage in horses naturally infected with Theileria equi

Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves

Evaluation of oxidative stress in sheep infected with Psoroptes ovis using total antioxidant capacity, total oxidant status, and malondialdehyde level

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