Investigation of some effective factors on urinary metabolites in biological monitoring of benzene, toluene, and xylene compounds

Taheri, Elnaz; Yousefinejad, Saeed; Dehghani, Fatemeh

doi:10.1080/03067319.2022.2097871

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Muconaldehyde is a six-carbon chain diene, and dialdehyde compound believed to cause benzene toxicity in the bone marrow 10 . Urinary Tt-MA can serve as a sensitive and specific indicator in biological examinations, especially in low-level benzene exposure 18,9,19 . tt-MA present in urine can detect benzene exposure as low as 0.1 ppm 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Benzene in urine contains phenylmercapturic acid and trans, trans-Muconic Acid (tt-MA). Exposure to benzene entering the body through inhalation can be identified by trans, trans-Muconic Acid (tt-MA) present in urine as a biological indicator 9 . Therefore, trans, trans-Muconic Acid (tt-MA) is a minor metabolite resulting from benzene compounds that can be used as a biological marker for individuals exposed to benzene in the body 3 This study aims to analyze the impact of airborne benzene exposure using the indicator trans, trans-Muconic Acid (tt-MA) and needs to be carried out to detect benzene exposure in workers more accurately.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Airborne Benzene Concentrations Increase Trans, Trans-Muconic Acid (tt-MA) Levels and Liver Function in Workers in The Manufacturing Industry

Kahar,

Hasan,

Prijanto

et al. 2024

woh

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The use of benzene as a solvent in the manufacturing industry can be dangerous because it is volatile, toxic, and carcinogenic. Exposure to benzene occurs through inhalation of the chemical in the air, which can enter the human body through the respiratory system. The levels of trans, trans-Muconic Acid (tt-MA), which is used to metabolize benzene, can be affected by the amount of exposure to the chemical. This study aims to determine the differences in exposure to benzene in the air by measuring the tt-MA indicators and liver function of workers in the manufacturing industry. This research uses an observational and cross-sectional approach, with a population of 158 employees from both administration and production units. The sample size for the study is 16 respondents, selected using the consecutive sampling technique. The research instrument uses a questionnaire and examines urine samples using the in-house method. Blood samples are examined using IFCC 37 C. The data is processed using the independent-sample t-test and Pearson correlation. The results show that the level of benzene in the air is below the threshold of 0.5 ppm. However, there is a significant difference in the results of tt-MA and SGOT (p<0.05), while the levels of SGPT (p>0.05) show no significant differences. In conclusion, there are differences in the tt-MA and SGOT exposure levels between workers in the production and toxicity units, while SGPT does not show significant differences. It is recommended that the industry maximizes the use of local exhaust ventilation and prohibits smoking.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%