Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats

Abstract

In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflammation induced by carragenan (Carr) at macro and micro levels. Therefore, in this study, 1 hour after administering intraperitoneal of indomethacin (Ind) or CAPE (10 and 30 mg/kg body weight) to Sprague Dawley rats, Carr was injected intraplantarly into their right paws. The paw volumes of the rats were measured with a plethysmometer until the 4th hour. Also, X-ray and thermal camera images were taken to determine edema and temperature changes. At the end of the study, after the paw tissues and serums were taken, oxidative stress and inflammation status were determined using biochemical, molecular, and western blot techniques. In addition, lipid and protein profiles in paw tissue were determined using HPTLC and electrophoresis methods. The results depicted that a high dose of CAPE against Carr-induced inflammation may be almost as effective as Ind used as reference.

Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway

“…Antioxidant enzymes and compounds play a key role in maintaining the oxidant/antioxidant balance in the organism 41 . Cells are exposed to oxidative stress as a result of decreased antioxidant activity and depletion of antioxidant compounds, and this increases oxidants 42 .…”

“…In this study, the effects of QUE on CYP-induced lung toxicity were investigated by evaluating oxidative stress, inflammation, Antioxidant enzymes and compounds play a key role in maintaining the oxidant/antioxidant balance in the organism. 41 Cells are exposed to oxidative stress as a result of decreased antioxidant activity and depletion of antioxidant compounds, and this increases oxidants. 42 Pesticides such as CYP cause excessive ROS formation, leading to a decrease in plasma or tissue antioxidant values.…”

Effects of Gold Nanoparticles Functionalized with Cornus mas L. Fruit Extract on the Aorta Wall in Rats with a High-Fat Diet and Experimental-Induced Diabetes Mellitus—An Imaging Study

“…The beneficial effects of natural extract might be explained by its chemical compounds that we identified through HPLC determination: flavonoids (naringenin, kaempferol, rutoside and their derivatives) that have been previously presented in the literature as part of this natural compound [ 32 , 33 , 34 ]; phenolic acids (caffeic and chlorogenic acids) mentioned by Bayram and Ozturkcan [ 35 ]; but also chrysin, hyperoside and luteolin. Several studies presented caffeic acid as an antioxidant [ 36 ], anti-inflammatory [ 37 ] and even a smooth muscle relaxing compound, as Siva et al showed in their study performed in organ bath using the rat thoracic aorta [ 38 ]. The other phenolic acid identified in Cornus mas L. extract, chlorogenic acid, was found in our previous studies as an efficient antioxidant and anti-inflammatory element, in a dose-dependent manner [ 39 , 40 ], Wu et al described this natural compound as anti-atherosclerotic [ 41 ], Hada et al as a potent inhibitor of aorta senescence in their study performed on mice with saline or angiotensin II administration [ 42 ], and many other studies indicated the beneficial effects of this acid.…”

Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model

“…Oxidative stress causes NF‐κB activation which leads to increased expression of pro‐inflammatory cytokines, thus triggering the inflammatory process 30,39–41 . The interaction between ER stress and inflammation has been extensively studied in cell types with metabolic or immune functions, and inflammation has been associated with unfolded protein response (UPR) activation to promote disease development 38 .…”

“…Oxidative stress causes NF-κB activation which leads to increased expression of pro-inflammatory cytokines, thus triggering the inflammatory process. 30,[39][40][41] The interaction between ER stress and inflammation has been extensively studied in cell types with metabolic or immune functions, and inflammation has been associated with unfolded protein response (UPR) activation to promote disease development. 38 In many previous studies, it has been reported that organophosphate compounds, including MLT, trigger inflammation by increasing the expression of pro-inflammatory cytokines in various tissues.…”