Investigation of the Anti-Inflammatory Potential of &lt;i&gt;Aloe vera&lt;/i&gt; Gel (97.5%) in the Ultraviolet Erythema Test

Reuter, Juliane; Jocher, Andrea; Stump, J.; Grossjohann, B.; Franke, G.; Schempp, Christoph M.

doi:10.1159/000114871

Cited by 58 publications

(32 citation statements)

References 42 publications

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“…Regarding human models, the effect of Aloe vera is usually studied in skin and epidermis related disorders (Reuter et al, 2008;Vogler and Ernst, 1999). Aloe vera has recently been shown to inhibit inflammatory responses by downregulating MMP-9 in peripheral blood leukocytes (PBLs), and to reduce cytokine (TNF␣ and IL-1␤) production in undifferentiated THP-1 cells and PBLs (Vijayalakshmi et al, 2012;Habeeb et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Budai

Varga

Milesz³

et al. 2013

Molecular Immunology

154

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a b s t r a c tAloe vera has been used in traditional herbal medicine as an immunomodulatory agent inducing antiinflammatory effects. However, its role on the IL-1␤ inflammatory cytokine production has not been studied. IL-1␤ production is strictly regulated both at transcriptional and posttranslational levels through the activity of Nlrp3 inflammasome. In this study we aimed to determine the effect of Aloe vera on the molecular mechanisms of Nlrp3 inflammasome-mediated IL-1␤ production in LPS-activated human THP-1 cells and monocyte-derived macrophages. Our results show that Aloe vera significantly reduced IL-8, TNF␣, IL-6 and IL-1␤ cytokine production in a dose dependent manner. The inhibitory effect was substantially more pronounced in the primary cells. We found that Aloe vera inhibited the expression of pro-IL-1␤, Nlrp3, caspase-1 as well as that of the P2X7 receptor in the LPS-induced primary macrophages. Furthermore, LPS-induced activation of signaling pathways like NF-B, p38, JNK and ERK were inhibited by Aloe vera in these cells.Altogether, we show for the first time that Aloe vera-mediated strong reduction of IL-1␤ appears to be the consequence of the reduced expression of both pro-IL-1␤ as well as Nlrp3 inflammasome components via suppressing specific signal transduction pathways. Furthermore, we show that the expression of the ATP sensor P2X7 receptor is also downregulated by Aloe vera that could also contribute to the attenuated IL-1␤ cytokine secretion. These results may provide a new therapeutic approach to regulate inflammasome-mediated responses.

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Section: Introductionmentioning

confidence: 99%

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Budai

Varga

Milesz³

et al. 2013

Molecular Immunology

154

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“…6 The herb is used in various conditions like digestive problems, asthma, immune system enhancement, peptic ulcer, externally in skin irritation, burns, scalds, sunburn wounds, eczema, acne, psoriasis, dermatitis, ulcers. 7,8 Aloe Vera also having antidiabetic activity. 9,10 There are established evidences on elevated levels of serum creatinine and urea being reduced by aloe vera in combination with standard antidiabetic drugs.…”

Section: Dangi Et Al Journal Of Chitwan Medical College 2015; 5(14)mentioning

confidence: 99%

Evaluation of aloe vera leaves extract in streptozotocin- induced diabetic nephropathy in rat

Dangi

Gyanwali

Gyanwali³

et al. 2017

J Chitwan Med Coll

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Having an anti-diabetic activity, Aloe Vera (Aloebarbadensis) has been used for medicinal purposes in several cultures for millennia. It has also been proved that aloe vera is having protective activity in nephrotoxic rats.The objective of the present study was to evaluate the effect of Aloe vera leaves extract on diabetic nephropathy in Streptozotocin-induced diabetic rat. Diabetes was induced by Streptozotocin(60 mg/kg-i.p.). Four weeks later rats were randomly selected and divided into 5 groups (n=6). Group I: normal control. Group II: diabetic nephropathy (DN) control. Group III: DN+AVE (250 mg/ kg). Group IV: DN+AVE (500 mg/kg). Group V: DN+AMG (1 mg/1ml in drinking water). The treatment was given for 8 weeks. Various parameters like physiological, antidiabetic, renal function, antioxidants and histopathology were measured. Administration of aloe vera extract showed significant decrease in body weight, food and water intake, kidney weight, blood glucose level, serum creatinine, BUN, protein in urine, serum uric acid and lipid peroxidation. It also significantly increases the plasma insulin level, liver glycogen content, urine volume, GFR, SOD, catalase, Reduced glutathione. Histopathological studies confirmed that administration of AVE prevented kidney damage, which provided structural support for the renal shielding effect. The significant effect of aloe vera extract on diabetic nephropathy could be due to the inherent antihyperglycemic, antioxidant, improvement of renal function parameters. In the near future AVE could constitute a lead to the discovery of a novel drug for the treatment of diabetic nephropathy.

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“…This plant is used in digestive problems, asthma, peptic ulcer, skin irritation, burns, wound, eczema, acne, psoriasis, dermatitis and diabetes (Puvabanditsin and Vongtongsri, 2005;Reuter et al, 2008;Mohamed, 2011;Yagi et al, 2011). It has been demonstrated that oral administration of mucilage of A. vera to type II diabetes Wistar rat improves the trend of wound healing by increasing in the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) which stimulates the fibroblast for reconstruction of extracellular matrix (Atiba et al, 2011;Mirmalek et al, 2015).…”

Section: Aloe Veramentioning

confidence: 99%

Medicinal plants with wound healing potential

Firdous¹,

Sautya²

2018

Bangladesh J Pharmacol

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Investigation of the Anti-Inflammatory Potential of <i>Aloe vera</i> Gel (97.5%) in the Ultraviolet Erythema Test

Cited by 58 publications

References 42 publications

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Evaluation of aloe vera leaves extract in streptozotocin- induced diabetic nephropathy in rat

Medicinal plants with wound healing potential

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