Investigation of the arterial intima-media thickness in Behcet’s disease patients without vascular complaints

Abstract

Objectives Behcet's disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet's disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet's disease without vascular involvement. Methods Twenty-four patients (average age: 38.50 ± 10.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet's disease were included in the study. Sixteen healthy subjects (average age: 39.75 ± 7.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet's disease patients and those of the control group ( p > 0.05). However, there was a significant difference between the neutrophil-lymphocyte ratio ( p = 0.004), low-density lipoprotein ( p = 0.007), and triglyceride ( p = 0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil-lymphocyte ratio levels ( p = 0.012) and the disease duration ( p = 0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration ( p = 0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet's disease. Blood neutrophil-lymphocyte ratio levels were also associated with increased intima-media thickness.

Could Fibrinogen to Albumin Ratio be a Predictive Marker for Recurrent Pregnancy Loss

“…Therefore, the NLR was investigated as a predictive marker for pathologic gestational events [11,12,13,14,15]. The NLR is the current concerted version as a predictor for inflammatory disorders, is especially investigated in atherosclerotic, thrombotic, and/or immune vascular events and is suggested as a potentially useful biomarker for prediction and follow-up for inflammatory processes [7,16]. Gezer et al investigated NLR values in determining the predictive value of subsequent preeclampsia.…”

Could fibrinogen to albumin ratio be a predictive marker for recurrent pregnancy loss

“…[11][12][13][14][15] The NLR is the current concerted version as a predictor for inflammatory disorders, is especially investigated in atherosclerotic, thrombotic, and/or immune vascular events, and is suggested as a potentially useful biomarker for prediction and follow-up for inflammatory processes. 7,16 Gezer et al 11 investigated NLR values in determining the predictive value of subsequent preeclampsia. 15 with a retrospective analysis that revealed similarly distributed NLR values in failed or successful pregnancies.…”

ACR Appropriateness Criteria® Nontraumatic Aortic Disease

“…Vascular duplex US can identify vascular wall thickening, which is an important marker in patients with generalized vascular inflammation [74], GCA [73,75], Behcet disease [76], and Takayasu arteritis [44]. Additionally, US is better than catheter-based angiography for detecting stenoses, occlusions, and aneurysms from Takayasu arteritis [44].…”