Investigation of the association between Toll-like receptor 2 gene polymorphisms and Behçet's disease in Japanese patients

Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies

“…TLR2, as a family member of TLRs, could activate an immunoreaction against M. TB via recognizing M. TB components and shaping pro-inflammatory signals [17]. Abundant studies proposed that TLR2 polymorphisms were involved in bacterial infections and various diseases [15,[18][19][20]. In the present study, the allele or genotype distribution of rs1898830 strongly differed between TB cases and controls in the initial cohort and it was replicated in the Tibetan sample.…”

Association ofTLR2Gene Polymorphisms With Ocular Behçet's Disease in a Chinese Han Population

“…[11][12][13] A positive association with TLR variants and Behçet's disease has been reported in some studies, 9,14 but could not be seen in others. [14][15][16][17] This may have been due to the small sample size used in these studies or to the fact that not all TLRs were studied. We repeated these studies and tested four different TLRs; and to obtain a sufficient sample size, we chose a number of frequently occurring noninfectious uveitis entities in a population of Chinese Han.…”

TLR2,TLR4 and CD86 gene polymorphisms in recurrent aphthous stomatitis

“…In this study, TLR4 but not TLR2 gene was associated with RAS. This observation was also noted in BD where TLR 4 was associated with BD but not TLR2 . Furthermore, levels of expression of TLR4 mRNA, but not of TLR2 mRNA, were constitutively increased in peripheral blood mononuclear cells (PBMCs) from patients with BD regardless of disease activity .…”