2016
DOI: 10.3892/etm.2016.3995
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Investigation of the effect of phlomisoside F on complete Freund's adjuvant-induced arthritis

Abstract: Abstract. Phlomis younghusbandii Mukerjee (Labiatae) has been reported to be effective in the treatment of rheumatoid arthritis (RA). In the present study, the anti-inflammatory and anti-arthritic effects of phlomisoside F (PF), isolated from P. younghusbandii Mukerjee (Labiatae), were investigated in male Wistar rats subjected to carrageen-induced paw edema and complete Freund's adjuvant (CFA)-induced arthritis. Arthritis scores were evaluated by a 5-point ordinal scale (scores 0-4). Expression levels of TNF-… Show more

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Cited by 31 publications
(18 citation statements)
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“…Even the intensity of liver injury was revealed at histological level with increased inflammatory infiltration. These results were in accordance with the results of other studies that have investigated the action of CFA-induced arthritis in rats [7, 20, 24, 4143].…”
Section: Discussionsupporting
confidence: 92%
“…Even the intensity of liver injury was revealed at histological level with increased inflammatory infiltration. These results were in accordance with the results of other studies that have investigated the action of CFA-induced arthritis in rats [7, 20, 24, 4143].…”
Section: Discussionsupporting
confidence: 92%
“…CFA is known to induce chronic inflammation by up-regulating the migration of lymphocytes and macrophages along with the release of inflammatory mediators such as TNF-α, IL-6, IL-1β, and IL-10 [ 15 , 18 ]. These mediators in turn, cause damage to the tissue and articular cartilages, leading to osteoarthritic conditions [ 19 ]. These changes were observed in the results of the CFA-induced model rats, with inflammatory cell infiltration in histopathological results and elevation of inflammatory mediators in ELISA analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Besides these changes, animals induced with arthritis was also found to show high arthritic index score and paw swelling [39]. Paw swelling indicates the measure of intensity of inflammation in CFA induced rats and reduction in paw swelling following treatment indicates the antiarthritic activity of the drug [40].…”
Section: Discussionmentioning
confidence: 99%