Investigation of the effect of donor platelet endothelial cell adhesion molecule 1 polymorphism on the graft-vs.-host disease occurrence in Tunisian recipients of hematopoietic stem cells

Sellami, M.; Torjemane, Lamia; Ladeb, Saloua; Kâabi, H.; Ahmed, Amira; Cherif, Ghaya; Midouni, B.; Othmane, Tarek Ben; Hmida, Slama

doi:10.1016/j.clinbiochem.2011.02.009

Cited by 2 publications

(3 citation statements)

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“…A study by Goodman et al . () also showed that the R643G polymorphism among donors was associated with increased risk of acute GvHD, although this finding was not confirmed in a Tunisian population (Sellami et al ., ). Because previous studies have reported complete linkage disequilibrium between the R643G and N563S polymorphisms (Maruya et al ., ; Grumet et al ., ), we genotyped only the R643G polymorphism in this study.…”

Section: Discussionmentioning

confidence: 97%

“…Subsequent studies reported both nonidentity and noncompatibility of two additional polymorphisms, the R643G (previously reported as the R670G) polymorphism and the N563S polymorphisms, to be associated with increased risk of acute GvHD (Maruya et al, 1998;Balduini et al, 1999;Grumet et al, 2001), although a larger multicenter study from the National Marrow Donor Program did not confirm this finding (Spellman et al, 2009). A study by Goodman et al (2005) also showed that the R643G polymorphism among donors was associated with increased risk of acute GvHD, although this finding was not confirmed in a Tunisian population (Sellami et al, 2011). Because previous studies have reported complete linkage disequilibrium between the R643G and N563S polymorphisms (Maruya et al, 1998;Grumet et al, 2001), we genotyped only the R643G polymorphism in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Because previous studies have reported complete linkage disequilibrium between the R643G and N563S polymorphisms (Maruya et al, 1998;Grumet et al, 2001), we genotyped only the R643G polymorphism in this study. Two studies have also shown no association between any of the PECAM1 SNPs (L98V, R643G and N563S) and chronic GvHD risk (Spellman et al, 2009;Sellami et al, 2011). L-selectin is a member of the selectin superfamily that is selectively expressed on all leucocytes (Carlos & Harlan, 1994).…”

Section: Discussionmentioning

confidence: 99%

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Association between genetic variants in adhesion molecules and outcomes after hematopoietic cell transplants

Thyagarajan

Jackson

Basu

et al. 2012

Int J Immunogenetics

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Allogeneic hematopoietic cell transplant (HCT) is associated with a high morbidity and mortality. Adhesion molecules play an important role in endothelial activation and initiation of inflammatory response. We hypothesized that single nucleotide polymorphisms (SNPs) in the endothelial molecules may contribute to heterogeneity in HCT outcomes. We evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft versus host disease (GvHD) and those experiencing transplant related mortality (TRM) within one year among 425 allogeneic HCT recipient-donor pairs. Using a Fine and Gray proportional hazards model to evaluate the association between genetic variants and clinical outcomes, after adjustment for recipient age, race, diagnosis, disease status, gender mismatch, CMV serostatus, gender, donor type, conditioning regimen and year of transplant, only rs5498 in the ICAM1 gene among both recipients and donors was associated with a decreased risk of TRM (p≤0.02). None of the SNPs were associated with acute or chronic GvHD risk. These findings suggest that genetic variants in the vascular adhesion molecules may be used to identify patients at high risk for TRM.

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Section: Discussionmentioning

confidence: 97%