Investigation of the effect of dietary intake of omega‐3 polyunsaturated fatty acids on trauma‐induced white matter injury with quantitative diffusion MRI in mice

Reyes, Laura D.; Haight, Thaddeus; Desai, Abhishek; Chen, Huazhen; Bosomtwi, Asamoah; Korotcov, Alexandru; Dardzinski, Bernard J.; Kim, Hee Yong; Pierpaoli, Carlo

doi:10.1002/jnr.24705

Cited by 5 publications

(1 citation statement)

References 56 publications

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“…Diminished antioxidant capacities can exacerbate neuroinflammation and depleted levels of omega-3 fatty acids that are required to maintain neuronal membrane fluidity can further compromise brain resiliency (Reyes et al, 2020a). In this regard, interest in nutritional supplementation as a prophylactic therapy to enhance brain resilience to damage in the case of neurotrauma -in particular sports-related concussions in at risk athletes -has been investigated (Walrand et al, 2021).…”

Section: Nutrition To Increase Resilience Against Tbimentioning

confidence: 99%

Nutrition and neutraceutical interventions as therapeutic strategies to aid recovery from mild traumatic brain injuries

Reichelt¹,

Dunkley²

2022

Preprint

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Concussion, sometimes called a mild traumatic brain injury (mTBI), is an acquired brain injury resulting in alterations to brain function underpinned by a sequence of neuropathological and neurometabolic events that can result in excitotoxicity, oxidative stress, oedema, neuroinflammation and cell death. To date, pharmaceutical therapies have had limited success in treating TBI, presenting considerable interest in nutritional therapies in the form of dietary supplementation to alleviate the deleterious pathological sequelae following neurotrauma. Many nutritional supplements have low toxicity, few drug interactions, and are already approved for human use making them attractive potential therapies following a concussion. In the setting of brain injury models, a considerable body of preclinical evidence has accumulated supporting the use of nutritional supplements including essential fatty acids, vitamins, minerals, amino acids, polyphenols, bioflavonoids and other bioactive compounds to facilitate aspects of functional recovery. Here, we review studies presenting diet supplements as therapeutic strategies as potential treatments for mTBI or to augment neurological resistance against mTBI in experimental models, as well as emerging therapeutic targets including the gut microbiome, and psychedelic and non-psychedelic compounds derived from fungi.

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Section: Nutrition To Increase Resilience Against Tbimentioning

confidence: 99%

Nutrition and neutraceutical interventions as therapeutic strategies to aid recovery from mild traumatic brain injuries

Reichelt¹,

Dunkley²

2022

Preprint

View full text Add to dashboard Cite

show abstract

Higher n-3 Polyunsaturated Fatty Acid Diet Improves Long-Term Neuropathological and Functional Outcome after Repeated Mild Traumatic Brain Injury

Desai

Chen

Kevala

et al. 2021

Journal of Neurotrauma

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Meningeal and Visual Pathway Magnetic Resonance Imaging Analysis after Single and Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA)-Induced Disruption in Male and Female Mice

McNamara

Knutsen

Korotcov

et al. 2022

Journal of Neurotrauma

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Investigation of the effect of dietary intake of omega‐3 polyunsaturated fatty acids on trauma‐induced white matter injury with quantitative diffusion MRI in mice

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 56 publications

Nutrition and neutraceutical interventions as therapeutic strategies to aid recovery from mild traumatic brain injuries

Nutrition and neutraceutical interventions as therapeutic strategies to aid recovery from mild traumatic brain injuries

Higher n-3 Polyunsaturated Fatty Acid Diet Improves Long-Term Neuropathological and Functional Outcome after Repeated Mild Traumatic Brain Injury

Meningeal and Visual Pathway Magnetic Resonance Imaging Analysis after Single and Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA)-Induced Disruption in Male and Female Mice

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