Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry

Erden, Omer; Imir, Ayse Gonca; Güvenal, Tevfik; Müslehiddinoğlu, Ahmet; Arici, Sema; Çetin, Meral; Çetin, Ali

doi:10.1093/humrep/del262

Cited by 36 publications

(30 citation statements)

References 29 publications

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“…Several studies on the effects of heparin on trophoblast invasion and modulation mechanisms and antiapoptotic decidual and placental tissues have shown benefits with the use of these medications 21,23 , which are consistent with the results of this study, in which no differences in fertility rates in Wistar rats exposed to enoxaparin and UFH in prophylactic or therapeutic doses were observed.…”

Section: Resultssupporting

confidence: 92%

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Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

Figueiró-Filho

Aydos²,

Senefonte³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats. METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of live and dead foetuses was quantified. The uterine horns were dissected and the presence of early and late reabsorptions (abortions) was determined. A p<0.05 was considered statistically significant. RESULTS:We did not observe statistically significant differences between groups when comparing the average weight of the foetuses and placentas, rate of female VS males, rates of pre-implantation loss (RPL), rates of efficiency implantation (REI), rates of postimplantation loss (RPIL) and rates of foetal viability (RFV). CONCLUSIONS:There was no significant effect on fertility with the use of anticoagulant drugs in pregnant healthy Wistar rats.

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Section: Resultssupporting

confidence: 92%

“…Experimental studies performed by Erden 21 and Curcelli 12 in rats exposed to heparin did not report bleeding. A systematic review comparing LMWH and UFH initially showed fewer bleeding episodes 22 .…”

Section: Resultsmentioning

confidence: 95%

Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

Figueiró-Filho

Aydos²,

Senefonte³

et al. 2014

Acta Cir. Bras.

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“…Heparin reduces the expression of E-cadherin and promotes trophoblast invasion and proliferation into the endometrial cells potentially improving implantation (95). A systematic review of women with recurrent implantation failure undergoing IVF demonstrated that use of adjunct low-molecular-weight heparin improved live birth rates, and the rate of miscarriage was substantially reduced compared with the control group (264).…”

Section: Thrombophiliamentioning

confidence: 99%

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

Hart

2016

Physiological Reviews

174

119

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Across the Western World there is an increasing trend to postpone childbearing. Consequently, the negative influence of age on oocyte quality may lead to a difficulty in conceiving for many couples. Furthermore, lifestyle factors may exacerbate a couple's difficulty in conceiving due mainly to the metabolic influence of obesity; however, the negative impacts of low peripheral body fat, excessive exercise, the increasing prevalence of sexually transmitted diseases, and smoking all have significant negative effects on fertility. Other factors that impede conception are the perceived increasing prevalence of the polycystic ovary syndrome, which is further exacerbated by obesity, and the presence of uterine fibroids and endometriosis (a progressive pelvic inflammatory disorder) which are more prevalent in older women. A tendency for an earlier sexual debut and to have more sexual partners has led to an increase in sexually transmitted diseases. In addition, there are several genetic influences that may limit the number of oocytes within the ovary; consequently, by postponing attempts at childbearing, a limitation of oocyte number may become evident, whereas in previous generations with earlier conception this potentially reduced reproductive life span did not manifest in infertility. Environmental influences on reproduction are under increasing scrutiny. Although firm evidence is lacking however, dioxin exposure may be linked to endometriosis, phthalate exposure may influence ovarian reserve, and bisphenol A may interfere with oocyte development and maturation. However, chemotherapy or radiotherapy is recognized to lead to ovarian damage and predispose the woman to ovarian failure.

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“…In contrast, the trophoblast expression of E-cadherin is higher in placentas of patients with preeclampsia, than in those of normal pregnant women 27 . The effect of heparin on E-cadherin expression was studied by Erden and coworkers 28 , who randomly treated female rats with different heparins (UFH, enoxaparin, and tinzaparin) during the preconceptional period, and examined E-cadherin expression in tissue sections of placenta and decidua from the different groups. The group treated by UFH had a lower E-cadherin placental staining than other study groups.…”

Section: Selectins and Cadherinsmentioning

confidence: 99%

The physiologic and therapeutic role of Heparin in implantation and placentation

Quaranta

Erez

Mastrolia

et al. 2014

Preprint

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Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture or membranes, preterm labor, and recurrent pregnancy loss). There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review we will summarize the properties and the physiological contribute of heparins to the success of implantation and placentation and normal pregnancy.PeerJ PrePrints | http://dx.doi.org/10.7287/peerj.preprints.486v1 | CC-BY 4.0 Open Access |

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Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry

Cited by 36 publications

References 29 publications

Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats

Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics

The physiologic and therapeutic role of Heparin in implantation and placentation

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