Investigation of the efficacy of daidzein in experimental knee osteoarthritis-induced with monosodium iodoacetate in rats

Gündoğdu, Gülşah; Miloğlu, Fatma Demirkaya; Gündoğdu, Köksal; Taşci, Şeymanur Yilmaz; Albayrak, Mevlüt; Demirci, Tuba; Çetin, Meltem

doi:10.1007/s10067-020-04958-z

Cited by 22 publications

(13 citation statements)

References 36 publications

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“…In an in vivo study, it was shown that TNF-α elevated in amniotic uid of women with preterm parturition [39]. Importantly, we found that supplementation with daidzein had a tendency to decrease the pro-in ammatory cytokine TNF-α content of the amniotic uid, which is consistent with a previous nding that daidzein supplementation suppressed pro-in ammatory cytokines such as TNF-α in the rat serum [40]. Thus, we speculated that daidzein supplementation can prevent embryonic developmental injury by decreasing the TNF-α level in the amniotic uid.…”

Section: Discussionsupporting

confidence: 92%

Daidzein Supplementation Enhances Embryos Survival by Improving Hormones, Antioxidant Capacity, and Metabolic Profiles of Amniotic Fluid in Sows

Xie

Chen

et al. 2020

Preprint

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Background: Daidzein (DAI) is a kind of natural isoflavonic phytoestrogen with estrogenic activity. However, little is known about its influence on early fetal growth in mammalian animals. In this study, we investigated the effects dietary DAI supplementation on early fetal development in sows. To explore the potential mechanisms, the metabolic profiles of amniotic ﬂuid collected at 35 days of gestation (dg) was determined by using metabolomics. Results: Results show that DAI supplementation at a dose of 200 mg/kg significantly enhanced the number of viable embryos at the early gestation stage (P < 0.05). DAI significantly elevated the concentrations of estrogen (E) and insulin-like growth factor-I (IGF-I) in the amniotic fluid (P < 0.05). Moreover, DAI tended to increase the concentration of progesterone, but decrease the concentration of tumor necrosis factor α (TNF-α) in the amniotic ﬂuid (0.05<P<0.10). Interestingly, the activity of glutathione peroxidase (GSH-Px) was higher in the DAI group than in the CON group (P < 0.05). An 1H NMR-based metabolomics analysis identified a number of metabolites in the amniotic fluid, and some critical metabolites such as arginine, creatine, and citrate were found to be significantly elevated upon DAI supplementation (P < 0.05). Importantly, the metabolic pathways involved in arginine and proline metabolisms were found to be significantly affected by DAI. Conclusions: These findings suggested that dietary DAI supplementation may improve embryos survival by improving hormones, antioxidant capacity, and metabolic profiles in the maternal amniotic ﬂuid.

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Section: Discussionsupporting

confidence: 92%

Daidzein Supplementation Enhances Embryos Survival by Improving Hormones, Antioxidant Capacity, and Metabolic Profiles of Amniotic Fluid in Sows

Xie

Chen

et al. 2020

Preprint

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“…There are various studies evaluating the effectiveness of hyaluronic acid in the treatment of osteoarthritis created by different methods. A study working on MIA-induced OA in rats compared HA, daidzein and their combination and found the daidzein treatment promising for OA, especially in combination with HA (16). In another study, the lubricin and lubricin+ hyaluronic acid groups were found superior than the hyaluronic acid and control groups, and the hyaluronic acid group was better than the control group following anterior cruciate ligament rupture in rats (18).…”

Section: Discussionmentioning

confidence: 98%

“…(7). In the literature review, it was determined that positive results were obtained from microfracture and HA applications individually and it was hypothesized that higher success could be achieved by combining the two (16,17,18).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of The Treatment Efficiency of Microfracture Technique and Intra-Articular Sodium Hyaluronate Injection on Osteoarthritis of Rats

Arda

Bozkan

2021

Dicle Üniversitesi Veteriner Fakültesi Dergisi

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The animals with osteoarthritis suffer from clinical signs such as joint pain, reluctance to move, loss of performance and lameness. Many medical and interventional methods are used to manage osteoarthritis but no described treatment can completely repair damaged cartilage yet. In this study, 40 male Wistar Albino rats were randomly assigned as microfracture technique group, intra-articular hyaluronic acid group, microfracture technique + intra-articular hyaluronic acid group and control group (n=10). Clinically, knee circumference and body weight were measured and, leg posture was scored. Radiological examination findings were evaluated using a grading based on 3 parameter as joint space narrowing, subchondral bone sclerosis, osteophyte formation. Also, at the end of the experiment, following sacrification, the joint of the relevant leg was scored according to the severity of osteoarthritis. Considering the changes in the leg posture, the knee circumference measurement and the radiological findings, the development of osteoarthritis was successfully achieved with monosodium iodoacetate application in this study. In line with the findings obtained from the presented study, it was concluded that combining microfracture technique with hyaluronic acid application would not contribute additionally to the treatment process, and even using microfracture or hyaluronic acid application alone may produce more positive results.

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“…It has been noted that the abnormally generated ROS exacerbates the in ammatory process in OA and aggravates ECM and joint degradation 10 . In ammation is the most signi cant cause of OA-related structural changes 19 .…”

Section: Discussionmentioning

confidence: 99%

“…This results in mitochondrial membrane damage, which leads to the release of caspases and pro-apoptotic molecules 7 . Also, ROS mediate the effect of pro-in ammatory cytokines; tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and interleukin-6 (IL-6), which prompt the synthesis of MMPs, in ammatory cytokines, and chemokines 10 . This in consequence leads to disturbance in cartilage homeostasis and promotes catabolism via induction of cell death 11,12 .…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant tempol delays the MIA-induced osteoarthritis progression in rats via modulation of signaling pathways involving TGF-β1/SMAD3/NOX4 axis

Abo-zalam

Abdel-Rahman

Abd-Ellah

et al. 2021

Preprint

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Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In the current study, we aimed to investigate the possible effects of tempol on knee OA induced by the chemical chondrotoxic monosodium iodoacetate (MIA) which closely mimics both the pain and structural changes associated with human OA. Rats were administrated oral tempol (100 mg/kg) one week post-MIA injection (3 mg/ 50 μL saline) at the right knee joints for 21 consecutive days. Tempol improved motor performance and debilitated the MIA-related radiological and histological alterations. Besides, it subsided the knee joint swelling. Tempol decreased the cartilage degradation-related biomarkers as matrix metalloproteinase-13, cartilage oligomeric matrix protein, and fibulin-3. The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor kappa-B (NF-κB), over-released insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1). Tempol decreased the expression of chemotactic cytokine ligand 2 (CCL2), dickkopf‑related protein-1 (DKK-1), and protein kinase C (PKC). On the molecular level, tempol reduced the phosphorylated protein levels of p38 mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), and small mother against decapentaplegic 3 homologs (SMAD3). These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-β1/SMAD3/NOX4, NOX4/p38MAPK/NF-κB, and PI3K/Akt/NF-κB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis, autophagy, and cell survival.

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Investigation of the efficacy of daidzein in experimental knee osteoarthritis-induced with monosodium iodoacetate in rats

Cited by 22 publications

References 36 publications

Daidzein Supplementation Enhances Embryos Survival by Improving Hormones, Antioxidant Capacity, and Metabolic Profiles of Amniotic Fluid in Sows

Daidzein Supplementation Enhances Embryos Survival by Improving Hormones, Antioxidant Capacity, and Metabolic Profiles of Amniotic Fluid in Sows

Evaluation of The Treatment Efficiency of Microfracture Technique and Intra-Articular Sodium Hyaluronate Injection on Osteoarthritis of Rats

The Antioxidant tempol delays the MIA-induced osteoarthritis progression in rats via modulation of signaling pathways involving TGF-β1/SMAD3/NOX4 axis

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