Employees spend a significant part of their lives in the workplace, and the time spent here wears them out physically, mentally, and psychologically. This situation, which we call employee attrition, makes itself felt more especially in places with job satisfaction and insufficient motivation. The main purpose of this research is to question the attrition of employees through loss of motivation, shrinkage of aim and organizational desensitization. The research method is cross-sectional research in quantitative and general screening models. The study's sample was determined according to the random sampling technique and consisted of employees working in different universities. The data of the research were collected by online survey method. The research examined the mediator and moderator role of organizational desensitization in the relationship between shrinkage of aim and loss of motivation in employees. In addition, the differences in the levels of loss of motivation, shrinkage of aim, and organizational desensitization, which are the sub-dimensions of attrition of the employees, were examined according to the demographic variables. According to the findings, it was determined that goal decrease and organizational desensitization positively affected the loss of motivation, and organizational desensitization had a mediating and regulatory role in the effect of goal decrease on motivation loss. These findings showed that a negative emotional state affects another negative emotional state in employees, and negative emotions affect other emotions with a kind of emotional contagion.